Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics (2007)
Dezfulian, Cameron, Raat, Nicolaas, Shiva, Sruti, Gladwin, Mark T.
The anion nitrite (NO2−) constitutes a biochemical reservoir for nitric oxide (NO). Nitrite reduction to NO may be catalyzed by hemoglobin, myoglobin or other metal-containing enzymes and occurs at...
The regulation of mitochondrial respiration by reactive nitrogen species / (2003)
Thesis (Ph. D.)--University of Alabama at Birmingham, School of Joint Health Sciences, 2003.
Shiva, Sruti, Brookes, Paul S., Patel, Rakesh P., Anderson, Peter G., Darley-Usmar, Victor M.
An emerging and important site of action for nitric oxide (NO) within cells is the mitochondrial inner membrane, where NO binds to and inhibits members of the electron transport chain, complex III...
Ramachandran, Anup, Moellering, Douglas R., Ceaser, Erin, Shiva, Sruti, Xu, Jun, Darley-Usmar, Victor
Mutations in mitochondrial DNA, affecting the activity of respiratory complexes, have been implicated in many chronic degenerative diseases. Mitochondrial proteins coded for by both the mitochondrial...
Biological activity of nitric oxide in the plasmatic compartment
Wang, Xunde, Tanus-Santos, Jose E., Reiter, Christopher D., Dejam, Andre, Shiva, Sruti, Smith, Reginald D., ...
There exist reaction products of nitric oxide (NO) with blood that conserve its bioactivity and transduce an endocrine vasomotor function under certain conditions. Although S-nitrosated albumin has...
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Zhi, Shiva, Sruti, Kim-Shapiro, Daniel B., Patel, Rakesh P., Ringwood, Lorna A., Irby, Cynthia E., ...
Hypoxic vasodilation is a fundamental, highly conserved physiological response that requires oxygen and/or pH sensing coupled to vasodilation. While this process was first characterized more than 80...
Mechanisms of the interaction of nitroxyl with mitochondria.
Shiva, Sruti, Crawford, Jack H, Ramachandran, Anup, Ceaser, Erin K, Hillson, Tess, Brookes, Paul S, ...
It is now thought that NO* (nitric oxide) and its redox congeners may play a role in the physiological regulation of mitochondrial function. The inhibition of cytochrome c oxidase by NO* is...
Landar, Aimee, Shiva, Sruti, Levonen, Anna-Liisa, Oh, Joo-Yeun, Zaragoza, Corinne, Johnson, Michelle S., ...
The electrophilic lipid 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is known to allow adaptation to oxidative stress in cells at low concentrations and apoptosis at high levels. The mechanisms...
Shiva, Sruti, Brookes, Paul S., Patel, Rakesh P., Anderson, Peter G., Darley-Usmar, Victor M.
An emerging and important site of action for nitric oxide (NO) within cells is the mitochondrial inner membrane, where NO binds to and inhibits members of the electron transport chain, complex III...
Ramachandran, Anup, Moellering, Douglas R., Ceaser, Erin, Shiva, Sruti, Xu, Jun, Darley-Usmar, Victor
Mutations in mitochondrial DNA, affecting the activity of respiratory complexes, have been implicated in many chronic degenerative diseases. Mitochondrial proteins coded for by both the mitochondrial...
Biological activity of nitric oxide in the plasmatic compartment
Wang, Xunde, Tanus-Santos, Jose E., Reiter, Christopher D., Dejam, Andre, Shiva, Sruti, Smith, Reginald D., ...
There exist reaction products of nitric oxide (NO) with blood that conserve its bioactivity and transduce an endocrine vasomotor function under certain conditions. Although S-nitrosated albumin has...
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Zhi, Shiva, Sruti, Kim-Shapiro, Daniel B., Patel, Rakesh P., Ringwood, Lorna A., Irby, Cynthia E., ...
Hypoxic vasodilation is a fundamental, highly conserved physiological response that requires oxygen and/or pH sensing coupled to vasodilation. While this process was first characterized more than 80...
Mechanisms of the interaction of nitroxyl with mitochondria.
Shiva, Sruti, Crawford, Jack H, Ramachandran, Anup, Ceaser, Erin K, Hillson, Tess, Brookes, Paul S, ...
It is now thought that NO* (nitric oxide) and its redox congeners may play a role in the physiological regulation of mitochondrial function. The inhibition of cytochrome c oxidase by NO* is...
Landar, Aimee, Shiva, Sruti, Levonen, Anna-Liisa, Oh, Joo-Yeun, Zaragoza, Corinne, Johnson, Michelle S., ...
The electrophilic lipid 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) is known to allow adaptation to oxidative stress in cells at low concentrations and apoptosis at high levels. The mechanisms...
Erythrocytes are the major intravascular storage sites of nitrite in human blood
Dejam, André, Hunter, Christian J., Pelletier, Mildred M., Hsu, Lewis L., Machado, Roberto F., Shiva, Sruti, ...
Plasma levels of nitrite ions have been used as an index of nitric oxide synthase (NOS) activity in vivo. Recent data suggest that nitrite is a potential intravascular repository for nitric oxide...
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
Crawford, Jack H., Isbell, T. Scott, Huang, Zhi, Shiva, Sruti, Chacko, Balu K., Schechter, Alan N., ...
Local vasodilation in response to hypoxia is a fundamental physiologic response ensuring oxygen delivery to tissues under metabolic stress. Recent studies identify a role for the red blood cell...
Shiva, Sruti, Sack, Michael N., Greer, James J., Duranski, Mark, Ringwood, Lorna A., Burwell, Lindsay, ...
Nitrite (NO2−) is an intrinsic signaling molecule that is reduced to NO during ischemia and limits apoptosis and cytotoxicity at reperfusion in the mammalian heart, liver, and brain. Although the...
Villagra, José, Shiva, Sruti, Hunter, Lori A., Machado, Roberto F., Gladwin, Mark T., Kato, Gregory J.
Increased platelet activation is recognized in patients with sickle cell disease (SCD), but its pathogenesis and clinical relevance remain uncertain. Pulmonary arterial hypertension (PAH), an...
Hendgen-Cotta, Ulrike B., Merx, Marc W., Shiva, Sruti, Schmitz, Joel, Becher, Stefanie, Klare, Johann P., ...
The nitrite anion is reduced to nitric oxide (NO•) as oxygen tension decreases. Whereas this pathway modulates hypoxic NO• signaling and mitochondrial respiration and limits myocardial infarction...
Minneci, Peter C., Deans, Katherine J., Shiva, Sruti, Zhi, Huang, Banks, Steven M., Kern, Steven, ...
Hemoglobin (Hb) potently inactivates the nitric oxide (NO) radical via a dioxygenation reaction forming nitrate (NO3−). This inactivation produces endothelial dysfunction during hemolytic...
Nitrite Reductase Activity of Cytochrome c*
Basu, Swati, Azarova, Natalia A., Font, Michael D., King, S. Bruce, Hogg, Neil, Gladwin, Mark T., ...
Small increases in physiological nitrite concentrations have now been shown to mediate a number of biological responses, including hypoxic vasodilation, cytoprotection after ischemia/reperfusion, and...