Nayak, Nihar R., Kuo, Calvin J., Desai, Tejal A., Wiegand, Stanley J., Lasley, Bill L., Giudice, Linda C., ...
Angiopoietin-1 (Ang-1) is an important angiogenic factor that has not been thoroughly studied in the primate endometrium. We evaluated the endometrial expression of Ang-1 and its receptor, Tie2,...
Intraretinal Transplantation for Rod-Cell Replacement in Light-Damaged Retinas (1989)
Manuel Del Cerro, Coca Del Cerro, Stanley J. Wiegand, Donald A. Grover, Eliot Lazar
Blindness from retinal disease is often the consequence of extensive damage to the photoreceptor cell population, while other cell types which form the neural retina are relatively spared. In this...
VEGF-Trap: A VEGF blocker with potent antitumor effects
Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, ...
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer....
Poulaki, Vassiliki, Qin, Wenying, Joussen, Antonia M., Hurlbut, Peter, Wiegand, Stanley J., Rudge, John, ...
Acute intensive insulin therapy is an independent risk factor for diabetic retinopathy. Here we demonstrate that acute intensive insulin therapy markedly increases VEGF mRNA and protein levels in the...
Uemura, Akiyoshi, Ogawa, Minetaro, Hirashima, Masanori, Fujiwara, Takashi, Koyama, Shinji, Takagi, Hitoshi, ...
Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via signaling molecules or physical contacts are implicated both in vascular remodeling and maintenance of vascular...
Cursiefen, Claus, Chen, Lu, Borges, Leonardo P., Jackson, David, Cao, Jingtai, Radziejewski, Czeslaw, ...
Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. In contrast, VEGF-A binds VEGFR1 and VEGFR2 and is...
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
Wortley, Katherine E., Anderson, Keith D., Garcia, Karen, Murray, Jane D., Malinova, Lubomira, Liu, Rong, ...
Ghrelin is a recently identified growth hormone (GH) secretogogue whose administration not only induces GH release but also stimulates food intake, increases adiposity, and reduces fat utilization in...
Uemura, Akiyoshi, Kusuhara, Sentaro, Wiegand, Stanley J., Yu, Ruth T., Nishikawa, Shin-Ichi
In response to hypoxia, hypoxia-inducible factors act as the primary proangiogenic triggers by regulating transcription levels of target genes, including VEGF. However, little is known about the...
VEGF-Trap: A VEGF blocker with potent antitumor effects
Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, ...
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer....
Poulaki, Vassiliki, Qin, Wenying, Joussen, Antonia M., Hurlbut, Peter, Wiegand, Stanley J., Rudge, John, ...
Acute intensive insulin therapy is an independent risk factor for diabetic retinopathy. Here we demonstrate that acute intensive insulin therapy markedly increases VEGF mRNA and protein levels in the...
Uemura, Akiyoshi, Ogawa, Minetaro, Hirashima, Masanori, Fujiwara, Takashi, Koyama, Shinji, Takagi, Hitoshi, ...
Interactions between endothelial cells (ECs) and perivascular mural cells (MCs) via signaling molecules or physical contacts are implicated both in vascular remodeling and maintenance of vascular...
Cursiefen, Claus, Chen, Lu, Borges, Leonardo P., Jackson, David, Cao, Jingtai, Radziejewski, Czeslaw, ...
Lymphangiogenesis, an important initial step in tumor metastasis and transplant sensitization, is mediated by the action of VEGF-C and -D on VEGFR3. In contrast, VEGF-A binds VEGFR1 and VEGFR2 and is...
Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference
Wortley, Katherine E., Anderson, Keith D., Garcia, Karen, Murray, Jane D., Malinova, Lubomira, Liu, Rong, ...
Ghrelin is a recently identified growth hormone (GH) secretogogue whose administration not only induces GH release but also stimulates food intake, increases adiposity, and reduces fat utilization in...
Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5
Macdonald, Lynn E., Wortley, Katherine E., Gowen, Lori C., Anderson, Keith D., Murray, Jane D., Poueymirou, William T., ...
We identified a glycoprotein hormone β-subunit (OGH, also called GPB5) that, as a heterodimer with the α-subunit GPA2, serves as a second ligand for the thyroid-stimulating hormone receptor. Mice...
Uemura, Akiyoshi, Kusuhara, Sentaro, Wiegand, Stanley J., Yu, Ruth T., Nishikawa, Shin-Ichi
In response to hypoxia, hypoxia-inducible factors act as the primary proangiogenic triggers by regulating transcription levels of target genes, including VEGF. However, little is known about the...
Joussen, Antonia M., Poulaki, Vassiliki, Qin, Wenying, Kirchhof, Bernd, Mitsiades, Nicholas, Wiegand, Stanley J., ...
Leukocyte adhesion to the diabetic retinal vasculature results in early blood-retinal barrier breakdown, capillary nonperfusion, and endothelial cell injury and death. Previous work has shown that...
Rudge, John S., Holash, Jocelyn, Hylton, Donna, Russell, Michelle, Jiang, Shelly, Leidich, Raymond, ...
VEGF is the best characterized mediator of tumor angiogenesis. Anti-VEGF agents have recently demonstrated impressive efficacy in human cancer trials, but the optimal dosing of such agents must still...
Intraretinal Transplantation for Rod-Cell Replacement in Light-Damaged Retinas
Del Cerro, Manuel, Notter, Mary F. D., Del Cerro, Coca, Wiegand, Stanley J., Grover, Donald A., Lazar, Eliot
Blindness from retinal disease is often the consequence of extensive damage to the photoreceptor cell population, while other cell types which form the neural retina are relatively spared. In this...
VEGF blockade inhibits angiogenesis and reepithelialization of endometrium
Fan, Xiujun, Krieg, Sacha, Kuo, Calvin J., Wiegand, Stanley J., Rabinovitch, Marlene, Druzin, Maurice L., ...
Despite extensive literature on vascular endothelial growth factor (VEGF) expression and regulation by steroid hormones, the lack of clear understanding of the mechanisms of angiogenesis in the...