Stavros J. Hamodrakas

Algorithms for incorporating prior topological information in HMMs: application to transmembrane proteins (2006)

Bagos, Pantelis G, Liakopoulos, Theodore D, Hamodrakas, Stavros J

Abstract Background Hidden Markov Models (HMMs) have been extensively used in computational molecular biology, for modelling protein and nucleic acid sequences. In many applications, such as...

A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models (2005)

Sgourakis, Nikolaos G, Bagos, Pantelis G, Papasaikas, Panagiotis K, Hamodrakas, Stavros J

Abstract Background G- Protein coupled receptors (GPCRs) comprise the largest group of eukaryotic cell surface receptors with great pharmacological interest. A broad range of native ligands interact...

Evaluation of methods for predicting the topology of β-barrel outer membrane proteins and a consensus prediction method (2005)

Bagos, Pantelis G, Liakopoulos, Theodore D, Hamodrakas, Stavros J

Abstract Background Prediction of the transmembrane strands and topology of β-barrel outer membrane proteins is of interest in current bioinformatics research. Several methods have been applied so...

A database for G proteins and their interaction with GPCRs (2004)

Elefsinioti, Antigoni L, Bagos, Pantelis G, Spyropoulos, Ioannis C, Hamodrakas, Stavros J

Abstract Background G protein-coupled receptors (GPCRs) transduce signals from extracellular space into the cell, through their interaction with G proteins, which act as switches forming...

cuticleDB: a relational database of Arthropod cuticular proteins (2004)

Magkrioti, Christiana K, Spyropoulos, Ioannis C, Iconomidou, Vassiliki A, Willis, Judith H, Hamodrakas, Stavros J

Abstract Background The insect exoskeleton or cuticle is a bi-partite composite of proteins and chitin that provides protective, skeletal and structural functions. Little information is available...

A Hidden Markov Model method, capable of predicting and discriminating β-barrel outer membrane proteins (2004)

Bagos, Pantelis G, Liakopoulos, Theodore D, Spyropoulos, Ioannis C, Hamodrakas, Stavros J

Abstract Background Integral membrane proteins constitute about 20–30% of all proteins in the fully sequenced genomes. They come in two structural classes, the α-helical and the β-barrel membrane...

GeneViTo: Visualizing gene-product functional and structural features in genomic datasets (2003)

Vernikos, Georgios S, Gkogkas, Christos G, Promponas, Vasilis J, Hamodrakas, Stavros J

Abstract Background The availability of increasing amounts of sequence data from completely sequenced genomes boosts the development of new computational methods for automated genome annotation and...

PRED-TMBB: a web server for predicting the topology of β-barrel outer membrane proteins

Bagos, Pantelis G., Liakopoulos, Theodore D., Spyropoulos, Ioannis C., Hamodrakas, Stavros J.

The β-barrel outer membrane proteins constitute one of the two known structural classes of membrane proteins. Whereas there are several different web-based predictors for α-helical membrane...

PRED-TMBB: a web server for predicting the topology of β-barrel outer membrane proteins

Bagos, Pantelis G., Liakopoulos, Theodore D., Spyropoulos, Ioannis C., Hamodrakas, Stavros J.

The β-barrel outer membrane proteins constitute one of the two known structural classes of membrane proteins. Whereas there are several different web-based predictors for α-helical membrane...