Steeve Giguère

Modulation of Cytokine Response of Pneumonic Foals by Virulent Rhodococcus equi

Giguère, Steeve, Wilkie, Bruce N., Prescott, John F.

The ability of Rhodococcus equi to induce pneumonia in foals depends on the presence of an 85- to 90-kb plasmid. In this study, we evaluated whether plasmid-encoded products mediate virulence by...

Cytokine Induction in Murine Macrophages Infected with Virulent and Avirulent Rhodococcus equi

Giguère, Steeve, Prescott, John F.

To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse...

Role of the 85-Kilobase Plasmid and Plasmid-Encoded Virulence-Associated Protein A in Intracellular Survival and Virulence of Rhodococcus equi

Giguère, Steeve, Hondalus, Mary K., Yager, Julie A., Darrah, Patricia, Mosser, David M., Prescott, John F.

Rhodococcus equi is a facultative intracellular pathogen of macrophages and a cause of pneumonia in young horses (foals) and immunocompromised people. Isolates of R. equi from pneumonic foals...

Performance of Five Serological Assays for Diagnosis of Rhodococcus equi Pneumonia in Foals

Giguère, Steeve, Hernandez, Jorge, Gaskin, Jack, Prescott, John F., Takai, Shinji, Miller, Corey

The performance of four enzyme-linked immunosorbent assays (ELISAs) (ELISA-6939, ELISA-33701, ELISA-VapA, and ELISA-California) and an agar gel immunodiffusion test for diagnosis of Rhodococcus equi...

In Vitro Susceptibilities of Rhodococcus equi and Other Common Equine Pathogens to Azithromycin, Clarithromycin, and 20 Other Antimicrobials

Jacks, Stephanie S., Giguère, Steeve, Nguyen, An

The objective of this study was to determine in vitro activities of azithromycin (AZM), clarithromycin (CLR), and 20 other antimicrobial agents against Rhodococcus equi and other common equine...

Modulation of Cytokine Response of Pneumonic Foals by Virulent Rhodococcus equi

Giguère, Steeve, Wilkie, Bruce N., Prescott, John F.

The ability of Rhodococcus equi to induce pneumonia in foals depends on the presence of an 85- to 90-kb plasmid. In this study, we evaluated whether plasmid-encoded products mediate virulence by...

Cytokine Induction in Murine Macrophages Infected with Virulent and Avirulent Rhodococcus equi

Giguère, Steeve, Prescott, John F.

To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse...

Role of the 85-Kilobase Plasmid and Plasmid-Encoded Virulence-Associated Protein A in Intracellular Survival and Virulence of Rhodococcus equi

Giguère, Steeve, Hondalus, Mary K., Yager, Julie A., Darrah, Patricia, Mosser, David M., Prescott, John F.

Rhodococcus equi is a facultative intracellular pathogen of macrophages and a cause of pneumonia in young horses (foals) and immunocompromised people. Isolates of R. equi from pneumonic foals...

Performance of Five Serological Assays for Diagnosis of Rhodococcus equi Pneumonia in Foals

Giguère, Steeve, Hernandez, Jorge, Gaskin, Jack, Prescott, John F., Takai, Shinji, Miller, Corey

The performance of four enzyme-linked immunosorbent assays (ELISAs) (ELISA-6939, ELISA-33701, ELISA-VapA, and ELISA-California) and an agar gel immunodiffusion test for diagnosis of Rhodococcus equi...

In Vitro Susceptibilities of Rhodococcus equi and Other Common Equine Pathogens to Azithromycin, Clarithromycin, and 20 Other Antimicrobials

Jacks, Stephanie S., Giguère, Steeve, Nguyen, An

The objective of this study was to determine in vitro activities of azithromycin (AZM), clarithromycin (CLR), and 20 other antimicrobial agents against Rhodococcus equi and other common equine...

In Vivo Expression of and Cell-Mediated Immune Responses to the Plasmid-Encoded Virulence-Associated Proteins of Rhodococcus equi in Foals▿

Jacks, Stephanie, Giguère, Steeve, Prescott, John F.

Rhodococcus equi is a facultative intracellular pathogen that causes pneumonia in foals but does not induce disease in adult horses. Virulence of R. equi depends on the presence of a large plasmid,...

Experimental Infection of Neonatal Foals with Rhodococcus equi Triggers Adult-Like Gamma Interferon Induction▿

Jacks, Stephanie, Giguère, Steeve, Crawford, P. Cynda, Castleman, William L.

Rhodococcus equi is a facultative intracellular pathogen that causes pneumonia in young foals but does not induce disease in immunocompetent adult horses. Clearance of R. equi depends mainly on gamma...

Foal Monocyte-Derived Dendritic Cells Become Activated upon Rhodococcus equi Infection▿ †

Nydam, Daryl V., Marquis, Hélène, Matychak, Mary Beth, Giguère, Steeve

Susceptibility of foals to Rhodococcus equi pneumonia is exclusive to the first few months of life. The objective of this study was to investigate the immediate immunologic response of foal and adult...