Hair loss and defective T- and B-cell function in mice lacking ORAI1 (2008)
Gwack, Yousang, Srikanth, Sonal, Oh-Hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...
ORAI1 is a pore subunit of the store-operated Ca(2+) release-activated Ca(2+) (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption...
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Kumar, Lalit, Feske, Stefan, Rao, Anjana, Geha, Raif S.
The adapter SLP-76 is essential for T cell development and function. SLP-76 binds to the src homology 3 domain of Lck in vitro. This interaction depends on amino acids 185–194 of SLP-76. To examine...
Kumar, Lalit, Feske, Stefan, Rao, Anjana, Geha, Raif S.
The adapter SLP-76 is essential for T cell development and function. SLP-76 binds to the src homology 3 domain of Lck in vitro. This interaction depends on amino acids 185–194 of SLP-76. To examine...
The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions
Wang, Ninghai, Satoskar, Abhay, Faubion, William, Howie, Duncan, Okamoto, Susumu, Feske, Stefan, ...
Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses...
Feske, Stefan, Prakriya, Murali, Rao, Anjana, Lewis, Richard S.
Engagement of the TCR triggers sustained Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels, which helps drive gene expression underlying the T cell response to pathogens. The identity...
Hair Loss and Defective T- and B-Cell Function in Mice Lacking ORAI1▿ †
Gwack, Yousang, Srikanth, Sonal, Oh-hora, Masatsugu, Hogan, Patrick G., Lamperti, Edward D., Yamashita, Megumi, ...
ORAI1 is a pore subunit of the store-operated Ca2+ release-activated Ca2+ (CRAC) channel. To examine the physiological consequences of ORAI1 deficiency, we generated mice with targeted disruption of...