Stefan Janssens

Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice (2009)

Nishida, Takefumi, De Yu, Jia, Minamishima, Shizuka, Sips, Patrick Y., Searles, Robert J., Buys, Emmanuel S., ...

Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserve (2009)

Van Den Bergh, An, Vangheluwe, Peter, Vanderper, Annelies, Carmeliet, Peter, Wuytack, Frank, Janssens, Stefan, ...

Aims Weight reduction programmes in morbidly obese, diabetic, and hyperlipidaemic subjects usually improve cardiac load and subsequently reverse hypertrophy. However, their effect on contractile...

Determinants and impact of microvascular obstruction in successfully reperfused ST-segment elevation myocardial infarction. Assessment by magnetic resonance imaging (2007)

Bogaert, Jan; U0008711, Kalantzi, Maria, Rademakers, Frank; U0004129, Dymarkowski, Steven; U0016915, Janssens, Stefan

Microvascular obstruction (MVO) is an important and independent determinant of post-infarct remodeling. Fifty-two patients with a successfully reperfused ST-segment elevation acute myocardial...

Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload (2007)

Buys, Emmanuel S, Raher, Michael J, Blake, Sarah L, Neilan, Tomas G, Graveline, Amanda R, Passeri, Jonathan J, ...

Although nitric oxide synthase (NOS) 3 is implicated as an important modulator of left ventricular (LV) remodeling, its role in the cardiac response to chronic pressure overload is controversial. We...

Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited (2007)

Pokreisz, Peter, Marsboom, Glenn, Janssens, Stefan

Right ventricular (RV) remodeling comprises multiple adaptation mechanisms to increased pressure- or volume-overload, which in concert determine RV performance as well as clinical outcome in...

ENOS potentiates the differentiation of adult cardiac side population cells in co-culture with cardiac myocytes (2006)

Dubroca, Caroline, Massion, Paul, Bouzin, Caroline, Feron, Olivier, Janssens, Stefan, Balligand, Jean-Luc

Cardiac-specific NOS3 overexpression rescues myocardial and neuronal function after cardiopulmonary resuscitation in NOS3-deficient mice (2006)

Nishida, Takefumi, Searles, Robert J, Shigematsu, Misako, Janssens, Stefan, Bloch, Kenneth D, Ichinose, Fumito

Effect of adenovirus-mediated gene transfer of nitric oxide synthase on vascular reactivity of rat isolated pulmonary arteries (2006)

Jiang, Leifu, Quarck, Rozenn; U0032950, Janssens, Stefan, Pokreisz, Peter; U0032789, Demedts, Maurice; U0008434, Delcroix, Marion; U0007588

Aerosol gene transfer of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) to rat lungs increased NOS expression and activity, and prevented hypoxic pulmonary vasoconstriction (HPV)...

Cardiomyocyte-specific overexpression of nitric oxide synthase 3 improves left ventricular remodeling in mice with chronic pressure overload (2006)

Buys, Emmanuel S, Jassal, Davinder S, Neilan, Tom G, Raher, Michael J, Ichinose, Fumito, Janssens, Stefan, ...

The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart (2006)

Bartunek, Jozef, Dimmeler, Stephanie, Drexler, Helmut, Fernandez-Aviles, Francisco, Galinanes, Manuel, Janssens, Stefan, ...

A task force has been established by the European Society of Cardiology to investigate the role of progenitor/stem cell therapy in the treatment of cardiovascular disease. This article is the...

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes (2004)

Van Laethem, An; U0041712, Van Kelst, Sofie, Lippens, Saskia, Declercq, Wim, Vandenabeele, Peter; U0004818, Janssens, Stefan, ...

This study establishes that activation of p38 MAPK by UVB represents a crucial signal required for the conformational change and translocation of Bax to the mitochondria in human keratinocytes....

Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs (2002)

Verhamme, Peter, Quarck, Rozenn, Hao, Hiroyuki, Knaapen, Michiel, Dymarkowski, Steven, Bernar, Hilde, ...

Objective: To study the effect of dietary cholesterol withdrawal on size and composition of LDL-hypercholesterolemia-induced coronary plaques in miniature pigs. Methods: Pigs were on normal chow...

Hypercholesterolemia impairs vascular remodelling after porcine coronary angioplasty (2002)

Theilmeier, Gregor, Quarck, Rozenn, Verhamme, Peter, Bochaton-Piallat, Marie-Luce, Lox, Marleen, Bernar, Hilde, ...

Objective: To assess the effect of hypercholesterolemia on neointima formation and vascular remodelling after porcine coronary angioplasty. Methods: Left anterior descending coronary angioplasty was...

Gene therapy in the cardiovascular system: an update (1999)

Sinnaeve, Peter, Varenne, Olivier, Collen, Désiré, Janssens, Stefan

This update reviews the remarkable progression in several cardiovascular gene transfer domains. The first chemical gene therapy protocols to stimulate angiogenesis in ischemic myocardium are...

EFFECTS OF THEOPHYLLINE ON CANINE DIAPHRAGMATIC CONTRACTILITY AND FATIGUE (1991)

Janssens, Stefan, Derom, Eric, Tjandramaga, TB, Decramer, Marc

To distinguish the effects of theophylline on respiratory muscle contractility from alterations in respiratory muscle interaction or blood flow, we examined in vitro contractile properties and...