Small RNAs Establish Delays and Temporal Thresholds in Gene Expression (2008)
Legewie, Stefan, Dienst, Dennis, Wilde, Annegret, Herzel, Hanspeter, Axmann, Ilka M.
Non-coding RNAs are crucial regulators of gene expression in prokaryotes and eukaryotes, but it remains poorly understood how they affect the dynamics of transcriptional networks. We analyzed the...
Stefan Legewie, Nils Blüthgen, Hanspeter Herzel
The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis induction by various stimuli including cytotoxic stress. It depends on the cellular context, whether...
Stefan Legewie, Nils Blüthgen, Hanspeter Herzel
The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis induction by various stimuli including cytotoxic stress. It depends on the cellular context, whether...
Ultrasensitization: Switch-Like Regulation of Cellular Signaling by Transcriptional Induction (2005)
Stefan Legewie, Nils Blüthgen, Reinhold Schäfer, Hanspeter Herzel
Cellular signaling networks are subject to transcriptional and proteolytic regulation under both physiological and pathological conditions. For example, the expression of proteins subject to covalent...
ULTRASENSITIZATION Switch-like Regulation of Cellular Signalling by Transcriptional Induction (2005)
Stefan Legewie, Nils Blüthgen, Reinhold Schäfer, Hanspeter Herzel
Cellular signalling networks are subject to transcriptional and proteolytic regulation under both physiological and pathological conditions. For example, the expression of proteins subject to...
Ultrasensitization: Switch-Like Regulation of Cellular Signaling by Transcriptional Induction
Legewie, Stefan, Blüthgen, Nils, Schäfer, Reinhold, Herzel, Hanspeter
Cellular signaling networks are subject to transcriptional and proteolytic regulation under both physiological and pathological conditions. For example, the expression of proteins subject to covalent...
Legewie, Stefan, Blüthgen, Nils, Herzel, Hanspeter
The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis induction by various stimuli including cytotoxic stress. It depends on the cellular context, whether...
Ultrasensitization: Switch-Like Regulation of Cellular Signaling by Transcriptional Induction
Legewie, Stefan, Blüthgen, Nils, Schäfer, Reinhold, Herzel, Hanspeter
Cellular signaling networks are subject to transcriptional and proteolytic regulation under both physiological and pathological conditions. For example, the expression of proteins subject to covalent...
Legewie, Stefan, Blüthgen, Nils, Herzel, Hanspeter
The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis induction by various stimuli including cytotoxic stress. It depends on the cellular context, whether...
Recurrent design patterns in the feedback regulation of the mammalian signalling network
Legewie, Stefan, Herzel, Hanspeter, Westerhoff, Hans V, Blüthgen, Nils
Biochemical networks are characterized by recurrent patterns and motifs, but the design principles underlying the dynamics of the mammalian intracellular signalling network remain unclear. We...
Competing Docking Interactions can Bring About Bistability in the MAPK Cascade
Legewie, Stefan, Schoeberl, Birgit, Blüthgen, Nils, Herzel, Hanspeter
Mitogen-activated protein kinases are crucial regulators of various cell fate decisions including proliferation, differentiation, and apoptosis. Depending on the cellular context, the Raf-Mek-Erk...
Systems-level interactions between insulin–EGF networks amplify mitogenic signaling
Borisov, Nikolay, Aksamitiene, Edita, Kiyatkin, Anatoly, Legewie, Stefan, Berkhout, Jan, Maiwald, Thomas, ...
Crosstalk mechanisms have not been studied as thoroughly as individual signaling pathways. We exploit experimental and computational approaches to reveal how a concordant interplay between the...
Small RNAs Establish Delays and Temporal Thresholds in Gene Expression
Legewie, Stefan, Dienst, Dennis, Wilde, Annegret, Herzel, Hanspeter, Axmann, Ilka M.
Noncoding RNAs are crucial regulators of gene expression in prokaryotes and eukaryotes, but how they affect the dynamics of transcriptional networks remains poorly understood. We analyzed the...