Marinissen, Maria Julia, Servitja, Joan-Marc, Offermanns, Stefan, Simon, Melvin I., Gutkind, J. Silvio
Although the ability of G protein-coupled receptors to stimulate normal and aberrant cell growth has been intensely investigated, the precise nature of the molecular mechanisms underlying their...
Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways (2002)
Gu, Jennifer L., Müller, Stefan, Mancino, Valeria, Offermanns, Stefan, Simon, Melvin I.
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a...
Klages, Birgit, Brandt, Ursula, Simon, Melvin I., Schultz, Günter, Offermanns, Stefan
Platelets respond to various stimuli with rapid changes in shape followed by aggregation and secretion of their granule contents. Platelets lacking the alpha-subunit of the heterotrimeric G protein...
Kano, Masanobu, Hashimoto, Kouichi, Watanabe, Masahiko, Kurihara, Hideo, Offermanns, Stefan, Jiang, Huiping, ...
Elimination of excess climbing fiber (CF)-Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Galpha q, and the...
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the alpha -subunit of the heterotrimeric guanine nucleotide binding protein Gq (Galpha q) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of...
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the alpha-subunit of the heterotrimeric guanine nucleotide binding protein G(q) (G alpha(q)) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of...
Gα15 and Gα16 Couple a Wide Variety of Receptors to Phospholipase C (1995)
Offermanns, Stefan, Simon, Melvin I.
The murine G-protein α-subunit Gα15 and its human counterpart Gα16 are expressed in a subset of hematopoietic cells, and they have been shown to regulate β-isoforms of inositide-specific...
Kano, Masanobu, Hashimoto, Kouichi, Watanabe, Masahiko, Kurihara, Hideo, Offermanns, Stefan, Jiang, Huiping, ...
Elimination of excess climbing fiber (CF)–Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Gαq, and the γ...
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the α-subunit of the heterotrimeric guanine nucleotide binding protein Gq (Gαq) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the...
Blaukat, Andree, Barac, Ana, Cross, Michael J., Offermanns, Stefan, Dikic, Ivan
G protein-coupled receptors (GPCRs) have been shown to stimulate extracellular regulated kinases (ERKs) through a number of linear pathways that are initiated by Gq/11 or Gi proteins. We studied...
Interaction of Gα12 with Gα13 and Gαq signaling pathways
Gu, Jennifer L., Müller, Stefan, Mancino, Valeria, Offermanns, Stefan, Simon, Melvin I.
The G12 subfamily of heterotrimeric G-proteins consists of two members, G12 and G13. Gene-targeting studies have revealed a role for G13 in blood vessel development. Mice lacking the α subunit of...
Wettschureck, Nina, Moers, Alexandra, Hamalainen, Tuula, Lemberger, Thomas, Schütz, Günther, Offermanns, Stefan
Heterotrimeric G proteins of the Gq/11 family transduce signals from a variety of neurotransmitter receptors and have therefore been implicated in several functions of the central nervous system. To...
GPR109A (PUMA-G/HM74A) mediates nicotinic acid–induced flushing
Benyó, Zoltán, Gille, Andreas, Kero, Jukka, Csiky, Marion, Suchánková, Marie Catherine, Nüsing, Rolf M., ...
Nicotinic acid (niacin) has long been used as an antidyslipidemic drug. Its special profile of actions, especially the rise in HDL-cholesterol levels induced by nicotinic acid, is unique among the...
Wettschureck, Nina, Van Der Stelt, Mario, Tsubokawa, Hiroshi, Krestel, Heinz, Moers, Alexandra, Petrosino, Stefania, ...
Metabotropic receptors coupled to Gq/G11 family G proteins critically contribute to nervous system functions by modulating synaptic transmission, often facilitating excitation. We investigated the...
Kano, Masanobu, Hashimoto, Kouichi, Watanabe, Masahiko, Kurihara, Hideo, Offermanns, Stefan, Jiang, Huiping, ...
Elimination of excess climbing fiber (CF)–Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Gαq, and the γ...
Offermanns, Stefan, Hashimoto, Kouichi, Watanabe, Masahiko, Sun, William, Kurihara, Hideo, Thompson, Richard F., ...
Mice lacking the α-subunit of the heterotrimeric guanine nucleotide binding protein Gq (Gαq) are viable but suffer from ataxia with typical signs of motor discoordination. The anatomy of the...
Blaukat, Andree, Barac, Ana, Cross, Michael J., Offermanns, Stefan, Dikic, Ivan
G protein-coupled receptors (GPCRs) have been shown to stimulate extracellular regulated kinases (ERKs) through a number of linear pathways that are initiated by Gq/11 or Gi proteins. We studied...
Interaction of Gα12 with Gα13 and Gαq signaling pathways
Gu, Jennifer L., Müller, Stefan, Mancino, Valeria, Offermanns, Stefan, Simon, Melvin I.
The G12 subfamily of heterotrimeric G-proteins consists of two members, G12 and G13. Gene-targeting studies have revealed a role for G13 in blood vessel development. Mice lacking the α subunit of...
Wettschureck, Nina, Moers, Alexandra, Hamalainen, Tuula, Lemberger, Thomas, Schütz, Günther, Offermanns, Stefan
Heterotrimeric G proteins of the Gq/11 family transduce signals from a variety of neurotransmitter receptors and have therefore been implicated in several functions of the central nervous system. To...
GPR109A (PUMA-G/HM74A) mediates nicotinic acid–induced flushing
Benyó, Zoltán, Gille, Andreas, Kero, Jukka, Csiky, Marion, Suchánková, Marie Catherine, Nüsing, Rolf M., ...
Nicotinic acid (niacin) has long been used as an antidyslipidemic drug. Its special profile of actions, especially the rise in HDL-cholesterol levels induced by nicotinic acid, is unique among the...
Wettschureck, Nina, Van Der Stelt, Mario, Tsubokawa, Hiroshi, Krestel, Heinz, Moers, Alexandra, Petrosino, Stefania, ...
Metabotropic receptors coupled to Gq/G11 family G proteins critically contribute to nervous system functions by modulating synaptic transmission, often facilitating excitation. We investigated the...
Thyrocyte-specific Gq/G11 deficiency impairs thyroid function and prevents goiter development
Kero, Jukka, Ahmed, Kashan, Wettschureck, Nina, Tunaru, Sorin, Wintermantel, Tim, Greiner, Erich, ...
The function of the adult thyroid is regulated by thyroid-stimulating hormone (TSH), which acts through a G protein–coupled receptor. Overactivation of the TSH receptor results in hyperthyroidism...
Plexin-B1/RhoGEF–mediated RhoA activation involves the receptor tyrosine kinase ErbB-2
Swiercz, Jakub M., Kuner, Rohini, Offermanns, Stefan
Plexins are widely expressed transmembrane proteins that mediate the effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still rather unclear. Plexin-B1 has...
Klages, Birgit, Brandt, Ursula, Simon, Melvin I., Schultz, Günter, Offermanns, Stefan
Platelets respond to various stimuli with rapid changes in shape followed by aggregation and secretion of their granule contents. Platelets lacking the α-subunit of the heterotrimeric G protein Gq...
Moers, Alexandra, Nürnberg, Alexander, Goebbels, Sandra, Wettschureck, Nina, Offermanns, Stefan
The heterotrimeric G proteins G12 and G13 link G-protein-coupled receptors to the regulation of the actin cytoskeleton and the induction of actomyosin-based cellular contractility. Here we show that...
Anaphylactic shock depends on endothelial Gq/G11
Korhonen, Hanna, Fisslthaler, Beate, Moers, Alexandra, Wirth, Angela, Habermehl, Daniel, Wieland, Thomas, ...
Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF),...