König, Fatima, Djukic, Marija, Gerber, Joachim, Schweyer, Stefan, Brück, Wolfgang, Schreiber, Stefan, ...
No abstract available.
Ralser, Markus, Nebel, Almut, Kleindorp, Rabea, Krobitsch, Sylvia, Lehrach, Hans, Schreiber, Stefan, ...
Abstract Background Triosephosphate isomerase (TPI) is a central and conserved glycolytic enzyme. In humans, TPI is encoded by a single gene on 12p13, and associated with a rare genetic disorder, TPI...
Rosenstiel, Philip, Huse, Klaus, Franke, Andre, Hampe, Jochen, Reichwald, Kathrin, Platzer, Cornelia, ...
Abstract Background NOD2 is an innate immune receptor for the bacterial cell wall component muramyl-dipeptide. Mutations in the leucine-rich repeat region of NOD2, which lead to an impaired...
Role of NOD2/CARD15in coronary heart disease (2007)
El Mokhtari, Nour Eddine, Ott, Stephan J, Nebel, Almut, Schäfer, Arne, Rosenstiel, Philip, Förster, Matti, ...
Abstract Background: Bacterial DNA has been repeatedly detected in atheromatous lesions of coronary heart disease (CHD) patients. Phylogenetic signatures in the atheroma lesions that are similar to...
Rattei, Thomas, Ott, Stephan, Gutacker, Michaela, Rupp, Jan, Maass, Matthias, Schreiber, Stefan, ...
Abstract Background Chlamydophila pneumoniae is an obligate intracellular bacterium that replicates in a biphasic life cycle within eukaryotic host cells. Four published genomes revealed an identity...
Szafranski, Karol, Schindler, Stefanie, Taudien, Stefan, Hiller, Michael, Huse, Klaus, Jahn, Niels, ...
Abstract Background Despite some degeneracy of sequence signals that govern splicing of eukaryotic pre-mRNAs, it is an accepted rule that U2-dependent introns exhibit the 3' terminal dinucleotide AG....
Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany (2006)
Schafmayer, Clemens, Hartleb, Jürgen, Tepel, Jürgen, Albers, Stefan, Freitag, Sandra, Völzke, Henry, ...
Abstract Background Gallstones represent a prevalent and costly health problem. The changing epidemiology and the emerging non-surgical interventions for gallstone disease necessitate the definition...
Phylogenetically widespread alternative splicing at unusual GYNGYN donors (2006)
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schreiber, Stefan, Backofen, Rolf, ...
Abstract Background Splice donor sites have a highly conserved GT or GC dinucleotide and an extended intronic consensus sequence GTRAGT that reflects the sequence complementarity to the U1 snRNA....
Elder, James T., Nair, Rajan, Kabelitz, Dietrich, Stuart, Philip, Schreiber, Stefan, Voorhees, John J., ...
Psoriasis has a strong genetic component in the development of the disease as indicated by familial occurrence and a high concordance rate among monozygotic twins. In genome-wide scans for psoriasis...
Analysis of NOD2-mediated Proteome Response to Muramyl Dipeptide in HEK293 Cells (2006)
Weichart, Dieter, Gobom, Johan, Klopfleisch, Sina, Häsler, Robert, Gustavsson, Niklas, Billmann, Susanne, ...
NOD2, a cytosolic receptor for the bacterial proteoglycan fragment muramyl dipeptide (MDP), plays an important role in the recognition of intracellular pathogens. Variants in the bacterial sensor...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays (2005)
Christine M. Costello, Nancy Mah, Robert Häsler, Philip Rosenstiel, Georg H. Waetzig, Andreas Hahn, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption (2005)
Spanagel, Rainer, Pendyala, Gurudutt, Abarca, Carolina, Zghoul, Tarek, Sanchis-Segura, Carles, Magnone, Maria Chiara, ...
Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2Brdm1 mutant mice, which have a deletion in the PAS...
The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption (2005)
Spanagel, Rainer, Pendyala, Gurudutt, Abarca, Carolina, Zghoul, Tarek, Sanchis-Segura, Carles, Magnone, Maria Chiara, ...
Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2Brdm1 mutant mice, which have a deletion in the PAS...
Can Zipf's law be adapted to normalize microarrays? (2005)
Lu, Tim, Costello, Christine M, Croucher, Peter JP, Häsler, Robert, Deuschl, Günther, Schreiber, Stefan
Abstract Background Normalization is the process of removing non-biological sources of variation between array experiments. Recent investigations of data in gene expression databases for varying...
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays (2005)
Costello, Christine M., Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H., Hahn, Andreas, ...
Background The differential pathophysiologic mechanisms that trigger and maintain the two forms of inflammatory bowel disease (IBD), Crohn disease (CD), and ulcerative colitis (UC) are only partially...
A comparison of oligonucleotide and cDNA-based microarray systems (2004)
Mah,Nancy, Thelin,Anders, Lu,Tim, Nikolaus,Susanna, Kuhbacher,Tanja, Gurbuz,Yesim, ...
Large-scale public data mining will become more common as public release of microarray data sets becomes a corequisite for publication. Therefore, there is an urgent need to clarify whether data from...
A comparison of oligonucleotide and cDNA-based microarray systems (2004)
Mah,Nancy, Thelin,Anders, Lu,Tim, Nikolaus,Susanna, Kuehbacher,Tanja, Gurbuz,Yesim, ...
Large-scale public data mining will become more common as public release of microarray data sets becomes a corequisite for publication. Therefore, there is an urgent need to clarify whether data from...
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll,Monika, Corneliussen,Brit, Costello,Christine M., Waetzig,Georg H., Mellgard,Bjorn, Koch,W. Andreas, ...
A comparison of oligonucleotide and cDNA-based microarray systems (2004)
Mah, Nancy, Thelin, Anders, Lu, Tim, Nikolaus, Susanna, Kuhbacher, Tanja, Gurbuz, Yesim, ...
Large-scale public data mining will become more common as public release of microarray data sets becomes a corequisite for publication. Therefore, there is an urgent need to clarify whether data from...
A comparison of oligonucleotide and cDNA-based microarray systems (2004)
Mah, Nancy, Thelin, Anders, Lu, Tim, Nikolaus, Susanna, Kuehbacher, Tanja, Gurbuz, Yesim, ...
Large-scale public data mining will become more common as public release of microarray data sets becomes a corequisite for publication. Therefore, there is an urgent need to clarify whether data from...
Genetic variation in DLG5 is associated with inflammatory bowel disease (2004)
Stoll, Monika, Corneliussen, Brit, Costello, Christine M., Waetzig, Georg H., Mellgard, Bjorn, Koch, W. Andreas, ...
Identification of mammalian orthologs associates PYPAF5 with distinct functional roles (2003)
Albrecht,Mario, Domingues,Francisco S., Schreiber,Stefan, Lengauer,Thomas
Identification of mammalian orthologs associates PYPAF5 with distinct functional roles (2003)
Albrecht, Mario, Domingues, Francisco S., Schreiber, Stefan, Lengauer, Thomas
Tümer,Zeynep, Croucher,Peter J. P., Jensen,Lars Riff, Hampe,Jochen, Hansen,Claus, Kalscheuer,Vera, ...
Chronic inflammatory bowel disease is a multifactorial disorder with two major clinical forms, Crohn's disease and ulcerative colitis. One of the potential susceptibility loci for inflammatory bowel...
Tümer, Zeynep, Croucher, Peter J. P., Jensen, Lars Riff, Hampe, Jochen, Hansen, Claus, Kalscheuer, Vera, ...
Chronic inflammatory bowel disease is a multifactorial disorder with two major clinical forms, Crohn's disease and ulcerative colitis. One of the potential susceptibility loci for inflammatory bowel...
Hampe,Jochen, Frenzel,Henning, Mirza,Muddassar M., Croucher,Peter J. P., Cuthbert,Andrew, Mascheretti,Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Hampe, Jochen, Frenzel, Henning, Mirza, Muddassar M., Croucher, Peter J. P., Cuthbert, Andrew, Mascheretti, Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Pharmakodynamik von Meropenem im Vergleich zu ähnlichen [beta]-Lactam-Antibiotika / (1997)
Thesis (doctoral)--Rheinische Friedrich-Wilhelms-Universität zu Bonn, 1997.
Literaturverz. S. 300 - 315.
Hampe, Jochen, Frenzel, Henning, Mirza, Muddassar M., Croucher, Peter J. P., Cuthbert, Andrew, Mascheretti, Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Ott, Stephan J., Musfeldt, Meike, Ullmann, Uwe, Hampe, Jochen, Schreiber, Stefan
The composition of the human intestinal flora is important for the health status of the host. The global composition and the presence of specific pathogens are relevant to the effects of the flora....
Can Zipf's law be adapted to normalize microarrays?
Lu, Tim, Costello, Christine M, Croucher, Peter JP, Häsler, Robert, Deuschl, Günther, Schreiber, Stefan
Nebel, Almut, Croucher, Peter J. P., Stiegeler, Rieke, Nikolaus, Susanna, Krawczak, Michael, Schreiber, Stefan
Human longevity is a multifactorial condition with a significant genetic contribution. A recent association study in two independent samples of long-lived U.S. Caucasians [long-lived individuals...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Linkage of Inflammatory Bowel Disease to Human Chromosome 6p
Hampe, Jochen, Shaw, Sarah H., Saiz, Robert, Leysens, Nancy, Lantermann, Annette, Mascheretti, Silvia, ...
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Given the immunologic...
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Jahn, Niels, Hampe, Jochen, Schreiber, Stefan, ...
Aberrant or modified splicing patterns of genes are causative for many human diseases. Therefore, the identification of genetic variations that cause changes in the splicing pattern of a gene is...
Rosenstiel, Philip, Huse, Klaus, Till, Andreas, Hampe, Jochen, Hellmig, Stephan, Sina, Christian, ...
Alterations in splicing patterns of genes contribute to the regulation of gene function by generating endogenous inhibitor or activator molecules. Nucleotide-binding and oligomerization domain (NOD)...
Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
Schafmayer, Clemens, Hartleb, Jürgen, Tepel, Jürgen, Albers, Stefan, Freitag, Sandra, Völzke, Henry, ...
Hampe, Jochen, Frenzel, Henning, Mirza, Muddassar M., Croucher, Peter J. P., Cuthbert, Andrew, Mascheretti, Silvia, ...
Heritable predisposition to inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic analysis. Linkage of IBD to broad regions of chromosome 16 has been established by...
Ott, Stephan J., Musfeldt, Meike, Ullmann, Uwe, Hampe, Jochen, Schreiber, Stefan
The composition of the human intestinal flora is important for the health status of the host. The global composition and the presence of specific pathogens are relevant to the effects of the flora....
Can Zipf's law be adapted to normalize microarrays?
Lu, Tim, Costello, Christine M, Croucher, Peter JP, Häsler, Robert, Deuschl, Günther, Schreiber, Stefan
Nebel, Almut, Croucher, Peter J. P., Stiegeler, Rieke, Nikolaus, Susanna, Krawczak, Michael, Schreiber, Stefan
Human longevity is a multifactorial condition with a significant genetic contribution. A recent association study in two independent samples of long-lived U.S. Caucasians [long-lived individuals...
Genetic Evidence for Interaction of the 5q31 Cytokine Locus and the CARD15 Gene in Crohn Disease
Mirza, Muddassar M., Fisher, Sheila A., King, Kathy, Cuthbert, Andrew P., Hampe, Jochen, Sanderson, Jeremy, ...
A common haplotype spanning 250 kb in the cytokine gene cluster on chromosome 5q31 has recently been reported to be strongly associated with Crohn disease (CD) in Canadian families. We have...
Giallourakis, Cosmas, Stoll, Monika, Miller, Katie, Hampe, Jochen, Lander, Eric S., Daly, Mark J., ...
Inflammatory bowel disease (IBD) refers to complex chronic relapsing autoimmune disorders of the gastrointestinal tract that have been traditionally classified into Crohn disease (CD) and ulcerative...
Dissection of the Inflammatory Bowel Disease Transcriptome Using Genome-Wide cDNA Microarrays
Costello, Christine M, Mah, Nancy, Häsler, Robert, Rosenstiel, Philip, Waetzig, Georg H, Hahn, Andreas, ...
cDNA analysis of colonic samples from patients with Crohn disease and ulcerative colitis suggests substantial differences in pathophysiology between the two diseases.
Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations
Mueller, Jakob C., Lõhmussaar, Elin, Mägi, Reedik, Remm, Maido, Bettecken, Thomas, Lichtner, Peter, ...
The pattern of linkage disequilibrium (LD) is critical for association studies, in which disease-causing variants are identified by allelic association with adjacent markers. The aim of this study is...
Hillmer, Axel M., Hanneken, Sandra, Ritzmann, Sibylle, Becker, Tim, Freudenberg, Jan, Brockschmidt, Felix F., ...
Androgenetic alopecia (AGA), or male-pattern baldness, is the most common form of hair loss. Its pathogenesis is androgen dependent, and genetic predisposition is the major requirement for the...
Linkage of Inflammatory Bowel Disease to Human Chromosome 6p
Hampe, Jochen, Shaw, Sarah H., Saiz, Robert, Leysens, Nancy, Lantermann, Annette, Mascheretti, Silvia, ...
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Given the immunologic...
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Jahn, Niels, Hampe, Jochen, Schreiber, Stefan, ...
Aberrant or modified splicing patterns of genes are causative for many human diseases. Therefore, the identification of genetic variations that cause changes in the splicing pattern of a gene is...
Rosenstiel, Philip, Huse, Klaus, Till, Andreas, Hampe, Jochen, Hellmig, Stephan, Sina, Christian, ...
Alterations in splicing patterns of genes contribute to the regulation of gene function by generating endogenous inhibitor or activator molecules. Nucleotide-binding and oligomerization domain (NOD)...
Predictors of gallstone composition in 1025 symptomatic gallstones from Northern Germany
Schafmayer, Clemens, Hartleb, Jürgen, Tepel, Jürgen, Albers, Stefan, Freitag, Sandra, Völzke, Henry, ...
Phylogenetically widespread alternative splicing at unusual GYNGYN donors
Hiller, Michael, Huse, Klaus, Szafranski, Karol, Rosenstiel, Philip, Schreiber, Stefan, Backofen, Rolf, ...
Computational and experimental evidence is given for alternative splicing at the unusual GYNGYN motif in several species, enabling in most cases subtle protein variations.
Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
Franke, Andre, Hampe, Jochen, Rosenstiel, Philip, Becker, Christian, Wagner, Florian, Häsler, Robert, ...
Crohn disease (CD), a sub-entity of inflammatory bowel disease (IBD), is a complex polygenic disorder. Although recent studies have successfully identified CD-associated genetic variants, these...
Efficacy assessment of SNP sets for genome-wide disease association studies
Wollstein, Andreas, Herrmann, Alexander, Wittig, Michael, Nothnagel, Michael, Franke, Andre, Nürnberg, Peter, ...
The power of a genome-wide disease association study depends critically upon the properties of the marker set used, particularly the number and physical spacing of markers, and the level of...
Rattei, Thomas, Ott, Stephan, Gutacker, Michaela, Rupp, Jan, Maass, Matthias, Schreiber, Stefan, ...