Stefan Schwartz

An intron 9 containing splice variant of PAX2 (2009)

Busse, Antonia, Rietz, Anika, Schwartz, Stefan, Thiel, Eckhard, Keilholz, Ulrich

Abstract Background PAX2 is a transcription factor with an important role in embryogenic development. However, PAX2 expression was frequently identified in neoplasia responsible for the growth and...

Chronic norovirus infection in renal transplant recipients (2009)

Westhoff, Timm H., Vergoulidou, Maria, Loddenkemper, Christoph, Schwartz, Stefan, Hofmann, Jörg, Schneider, Thomas, ...

Norovirus infection is the most common cause of acute gastroenteritis. In immunocompetent subjects, norovirus infection is a self-limiting disease of short duration. The present report provides first...

No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms (2007)

Burmeister, Thomas, Schwartz, Stefan, Hummel, Michael, Hoelzer, Dieter, Thiel, Eckhard

Abstract Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia...

NUP214-ABL1 in adult T-ALL: the GMALL study group experience (2006)

Burmeister, Thomas, Goekbuget, Nicola, Reinhardt, Richard, Rieder, Harald, Hoelzer, Dieter, Schwartz, Stefan

The NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia (T-ALL) has recently been identified as a possible target for imatinib and related tyrosine kinase inhibitors, but exact data...

Quality assurance of exposure models for environmental risk assessment of substances / (2000)

Schwartz, Stefan.

Osnabrück, Univ., Diss., 2000.

Quality assurance of exposure models for environmental risk assessment of substances (2000)

Schwartz, Stefan

Environmental risk assessment of chemical substances in the European Union is based on a harmonised scheme. The required models and parameters are laid down in the Technical Guidance Document (TGD)...

Organische Schadstoffe in der Nahrungskette : Vorstudie zur Validierung von Expositionsmodellen / (1997)

Schwartz, Stefan.

Zugl.: Osnabrück, Univ., Diplomarbeit, 1997.

The Inhibitory Activity of the AU-Rich RNA Element in the Human Papillomavirus Type 1 Late 3′ Untranslated Region Correlates with Its Affinity for the elav-Like HuR Protein

Sokolowski, Marcus, Furneaux, Henry, Schwartz, Stefan

A 57-nucleotide adenosine- and uridine-rich RNA instability element in the human papillomavirus type 1 late 3′ untranslated region termed h1ARE has previously been shown to interact specifically...

mRNA Instability Elements in the Human Papillomavirus Type 16 L2 Coding Region

Sokolowski, Marcus, Tan, Wei, Jellne, Marianne, Schwartz, Stefan

Human papillomavirus capsid proteins L1 and L2 are detected only in terminally differentiated cells, indicating that expression of the L1 and L2 genes is blocked in dividing cells. The results...

Specific Inactivation of Inhibitory Sequences in the 5′ End of the Human Papillomavirus Type 16 L1 Open Reading Frame Results in Production of High Levels of L1 Protein in Human Epithelial Cells

Collier, Brian, Öberg, Daniel, Zhao, Xiaomin, Schwartz, Stefan

The expression of human papillomavirus type 16 late genes encoding virus capsid proteins L1 and L2 is restricted to terminally differentiated epithelial cells in the superficial layers of the...

Mutational Inactivation of Two Distinct Negative RNA Elements in the Human Papillomavirus Type 16 L2 Coding Region Induces Production of High Levels of L2 in Human Cells

Öberg, Daniel, Collier, Brian, Zhao, Xiaomin, Schwartz, Stefan

Here we show that the 5′ end and the middle region of the L2 coding sequence of human papillomavirus type 16 contain strong inhibitory RNA sequences termed inhibitory regions I and II. This is in...

Identification of an hnRNP A1-Dependent Splicing Silencer in the Human Papillomavirus Type 16 L1 Coding Region That Prevents Premature Expression of the Late L1 Gene

Zhao, Xiaomin, Rush, Margaret, Schwartz, Stefan

We have previously identified cis-acting RNA sequences in the human papillomavirus type 16 (HPV-16) L1 coding region which inhibit expression of L1 from eukaryotic expression plasmids. Here we have...

A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein

Zhao, Xiaomin, Öberg, Daniel, Rush, Margaret, Fay, Joanna, Lambkin, Helen, Schwartz, Stefan

We have investigated the role of the human papillomavirus type 16 (HPV-16) early untranslated region (3′ UTR) in HPV-16 gene expression. We found that deletion of the early 3′ UTR reduced the...

A Splicing Enhancer in the E4 Coding Region of Human Papillomavirus Type 16 Is Required for Early mRNA Splicing and Polyadenylation as Well as Inhibition of Premature Late Gene Expression

Rush, Margaret, Zhao, Xiaomin, Schwartz, Stefan

Successful inhibition of human papillomavirus type 16 (HPV-16) late gene expression early in the life cycle is essential for persistence of infection, the highest risk factor for cervical cancer. Our...

A Downstream Polyadenylation Element in Human Papillomavirus Type 16 L2 Encodes Multiple GGG Motifs and Interacts with hnRNP H

Öberg, Daniel, Fay, Joanna, Lambkin, Helen, Schwartz, Stefan

Production of human papillomavirus type 16 (HPV-16) virus particles is totally dependent on the differentiation-dependent induction of viral L1 and L2 late gene expression. The early polyadenylation...

The Inhibitory Activity of the AU-Rich RNA Element in the Human Papillomavirus Type 1 Late 3′ Untranslated Region Correlates with Its Affinity for the elav-Like HuR Protein

Sokolowski, Marcus, Furneaux, Henry, Schwartz, Stefan

A 57-nucleotide adenosine- and uridine-rich RNA instability element in the human papillomavirus type 1 late 3′ untranslated region termed h1ARE has previously been shown to interact specifically...

mRNA Instability Elements in the Human Papillomavirus Type 16 L2 Coding Region

Sokolowski, Marcus, Tan, Wei, Jellne, Marianne, Schwartz, Stefan

Human papillomavirus capsid proteins L1 and L2 are detected only in terminally differentiated cells, indicating that expression of the L1 and L2 genes is blocked in dividing cells. The results...

Specific Inactivation of Inhibitory Sequences in the 5′ End of the Human Papillomavirus Type 16 L1 Open Reading Frame Results in Production of High Levels of L1 Protein in Human Epithelial Cells

Collier, Brian, Öberg, Daniel, Zhao, Xiaomin, Schwartz, Stefan

The expression of human papillomavirus type 16 late genes encoding virus capsid proteins L1 and L2 is restricted to terminally differentiated epithelial cells in the superficial layers of the...

Mutational Inactivation of Two Distinct Negative RNA Elements in the Human Papillomavirus Type 16 L2 Coding Region Induces Production of High Levels of L2 in Human Cells

Öberg, Daniel, Collier, Brian, Zhao, Xiaomin, Schwartz, Stefan

Here we show that the 5′ end and the middle region of the L2 coding sequence of human papillomavirus type 16 contain strong inhibitory RNA sequences termed inhibitory regions I and II. This is in...

Identification of an hnRNP A1-Dependent Splicing Silencer in the Human Papillomavirus Type 16 L1 Coding Region That Prevents Premature Expression of the Late L1 Gene

Zhao, Xiaomin, Rush, Margaret, Schwartz, Stefan

We have previously identified cis-acting RNA sequences in the human papillomavirus type 16 (HPV-16) L1 coding region which inhibit expression of L1 from eukaryotic expression plasmids. Here we have...

A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein

Zhao, Xiaomin, Öberg, Daniel, Rush, Margaret, Fay, Joanna, Lambkin, Helen, Schwartz, Stefan

We have investigated the role of the human papillomavirus type 16 (HPV-16) early untranslated region (3′ UTR) in HPV-16 gene expression. We found that deletion of the early 3′ UTR reduced the...

A Downstream Polyadenylation Element in Human Papillomavirus Type 16 L2 Encodes Multiple GGG Motifs and Interacts with hnRNP H

Öberg, Daniel, Fay, Joanna, Lambkin, Helen, Schwartz, Stefan

Production of human papillomavirus type 16 (HPV-16) virus particles is totally dependent on the differentiation-dependent induction of viral L1 and L2 late gene expression. The early polyadenylation...

A Splicing Enhancer in the E4 Coding Region of Human Papillomavirus Type 16 Is Required for Early mRNA Splicing and Polyadenylation as Well as Inhibition of Premature Late Gene Expression

Rush, Margaret, Zhao, Xiaomin, Schwartz, Stefan

Successful inhibition of human papillomavirus type 16 (HPV-16) late gene expression early in the life cycle is essential for persistence of infection, the highest risk factor for cervical cancer. Our...

No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms

Burmeister, Thomas, Schwartz, Stefan, Hummel, Michael, Hoelzer, Dieter, Thiel, Eckhard

Polypyrimidine Tract Binding Protein Induces Human Papillomavirus Type 16 Late Gene Expression by Interfering with Splicing Inhibitory Elements at the Major Late 5′ Splice Site, SD3632▿

Somberg, Monika, Zhao, Xiaomin, Fröhlich, Monika, Evander, Magnus, Schwartz, Stefan

We have initiated a screen for cellular factors that can induce human papillomavirus type 16 (HPV-16) late gene expression in human cancer cells. We report that the overexpression of polypyrimidine...

CD56 expression in T-cell acute lymphoblastic leukemia is associated with non-thymic phenotype and resistance to induction therapy but no inferior survival after risk-adapted therapy

Fischer, Lars, Gökbuget, Nicola, Schwartz, Stefan, Burmeister, Thomas, Rieder, Harald, Brüggemann, Monika, ...

The findings of this study indicate that CD56 is expressed on a subset of adult T-cell acute lymphoblastic leukemia cells with distinct immunophenotypic features and greater resistance to therapy....

An intron 9 containing splice variant of PAX2

Busse, Antonia, Rietz, Anika, Schwartz, Stefan, Thiel, Eckhard, Keilholz, Ulrich

Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia

Baldus, Claudia D., Thibaut, Julia, Goekbuget, Nicola, Stroux, Andrea, Schlee, Cornelia, Mossner, Max, ...

NOTCH1 mutations are found in more than 50 % of patients with T-lineage acute lymphoblastic leukemia (TALL), and have been associated with a favorable outcome in pediatric T-ALL. FBXW7 mutations are...