Mühlberger, Nikolai, Schwarzer, Ruth, Lettmeier, Beate, Sroczynski, Gaby, Zeuzem, Stefan, Siebert, Uwe
Abstract Background Hepatitis C virus (HCV) is a leading cause of chronic liver disease, end-stage cirrhosis, and liver cancer, but little is known about the burden of disease caused by the virus. We...
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. (2009)
Hézode, Christophe, Forestier, Nicole, Dusheiko, Geoffrey, Ferenci, Peter, Pol, Stanislas, Goeser, Tobias, ...
BACKGROUND: In patients with chronic infection with hepatitis C virus (HCV) genotype 1, treatment with peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic response...
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. (2009)
Hézode, Christophe, Forestier, Nicole, Dusheiko, Geoffrey, Ferenci, Peter, Pol, Stanislas, Goeser, Tobias, ...
BACKGROUND: In patients with chronic infection with hepatitis C virus (HCV) genotype 1, treatment with peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic response...
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. (2009)
Hézode, Christophe, Forestier, Nicole, Dusheiko, Geoffrey, Ferenci, Peter, Pol, Stanislas, Goeser, Tobias, ...
BACKGROUND: In patients with chronic infection with hepatitis C virus (HCV) genotype 1, treatment with peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic response...
Long-term effectiveness and cost-effectiveness of screening for Hepatitis C virus infection (2009)
Sroczynski, Gaby, Esteban, Eva, Conrads-Frank, Annette, Schwarzer, Ruth, Mühlberger, Nikolai, Wright, Davene, ...
Background: Hepatitis C virus (HCV) infection is an emerging problem in public health. In most countries, the majority of HCV infected people are yet undiagnosed. Early detection and treatment may...
Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Abstract Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This...
Plotz, Guido, Raedle, Jochen, Spina, Anna, Welsch, Christoph, Stallmach, Andreas, Zeuzem, Stefan, ...
Welsch, Christoph, Domingues, Francisco S., Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Hofmann, Wolf Peter, Welsch, Christoph, Takahashi, Yoshitomo, Miyajima, Hiroaki, Mihm, Ulrike, Krick, Christoph, ...
Background. Hereditary aceruloplasminemia is an adult-onset autosomal recessive disease characterized by increased iron overload in the liver, pancreas, retina, and central nervous system. So far, 45...
Welker, Martin W., Hofmann, Wolf-Peter, Welsch, Christoph, Von Wagner, Michael, Herrmann, Eva, Lengauer, Thomas, ...
Structural and functional comparison of the non-structural protein 4B in flaviviridae (2007)
Welsch, Christoph, Albrecht, Mario, Maydt, Jochen, Herrmann, Eva, Welker, Martin W., Sarrazin, Christoph, ...
Hofmann, Wolf Peter, Fernandez, B., Herrmann, E., Welsch, Christoph, Mihm, Ulrike, Kronenberg, B., ...
Hansen, Bettina E, Willems, Marc, Brouwer, Johannes T, Huber, Roman, Kullak-Ublick, Gerd A, ...
BACKGROUND/AIMS: Phase I/II studies of 4 weeks duration have confirmed the ALT lowering effect of glycyrrhizin in Western chronic hepatitis C patients. Our aim was to determine the dose frequency of...
Wiegand, Johannes, Buggisch, Peter, Boecher, Wulf, Zeuzem, Stefan, Gelbmann, Cornelia M., Berg, Thomas, ...
Early treatment of acute hepatitis C with interferon alpha-2b for 24 weeks prevents chronic infection in almost all patients. Because pegylated interferons have replaced conventional interferon in...
Mutations in the MutSalpha interaction interface of {MLH1} can abolish {DNA} mismatch repair (2006)
Plotz, Guido, Welsch, Christoph, Giron-Monzon, Luis, Friedhoff, Peter, Albrecht, Mario, Piiper, Albrecht, ...
MutL, a heterodimer of MLH1 and PMS2, plays a central role in human DNA mismatch repair. It interacts ATP-dependently with the mismatch detector MutS and assembles and controls further repair...
Mihm, Ulrike, Grigorian, Natalia, Welsch, Christoph, Herrmann, Eva, Kronenberger, Bernd, Teuber, Gerlinde, ...
Sarrazin, Christoph, Mihm, Ulrike, Herrmann, Eva, Welsch, Christoph, Albrecht, Mario, Sarrazin, Ulrike, ...
Hadziyannis, Stephanos J., Sette, Hoel, JrMorgan, Timothy R., Balan, Vijayan, Diago, Moises, Marcellin, Patrick, ...
BACKGROUND: Treatment with pegylated interferon (peginterferon) and ribavirin for 48 weeks is more effective than conventional interferon and ribavirin in patients with chronic hepatitis C....
N-terminus of hMLH1 confers interaction of hMutL{alpha} and hMutL{beta} with hMutS{alpha} (2003)
Plotz, Guido, Raedle, Jochen, Brieger, Angela, Trojan, Jörg, Zeuzem, Stefan
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and...
hMutS{alpha} forms an ATP-dependent complex with hMutL{alpha} and hMutL{beta} on DNA (2002)
Plotz, Guido, Raedle, Jochen, Brieger, Angela, Trojan, Jörg, Zeuzem, Stefan
The DNA binding properties of hMutSα and hMutLα and complex formation of hMutSα with hMutLα and hMutL&bgr; were investigated using binding experiments on magnetic bead-coupled DNA substrates with...
Frankfurt (Main), Univ., Habil.-Schr., 1992.
Sarrazin, Christoph, Hendricks, David A., Sedarati, Farhad, Zeuzem, Stefan
Transcription-mediated amplification (TMA) is an isothermal, autocatalytic target amplification method which has the potential to detect less than 50 hepatitis C virus (HCV) RNA copies/ml (10 IU/ml)....
hMutSα forms an ATP-dependent complex with hMutLα and hMutLβ on DNA
Plotz, Guido, Raedle, Jochen, Brieger, Angela, Trojan, Jörg, Zeuzem, Stefan
The DNA binding properties of hMutSα and hMutLα and complex formation of hMutSα with hMutLα and hMutLβ were investigated using binding experiments on magnetic bead-coupled DNA substrates with...
Sarrazin, Christoph, Herrmann, Eva, Bruch, Katharina, Zeuzem, Stefan
Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1...
N-terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα
Plotz, Guido, Raedle, Jochen, Brieger, Angela, Trojan, Jörg, Zeuzem, Stefan
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2-hMSH6) and hMutLα...
Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 CellsD⃞
Kiermayer, Simone, Biondi, Ricardo M., Imig, Jochen, Plotz, Guido, Haupenthal, Jörg, Zeuzem, Stefan, ...
Elevation of the intracellular cAMP concentration ([cAMP]i) regulates metabolism, cell proliferation, and differentiation and plays roles in memory formation and neoplastic growth. cAMP mediates its...
Sarrazin, Christoph, Gärtner, Barbara C., Sizmann, Dorothea, Babiel, Rainer, Mihm, Ulrike, Hofmann, Wolf Peter, ...
The key parameter for diagnosis and management of hepatitis C virus (HCV) infection is HCV RNA. Standardization of HCV RNA assays to IU is mainly based on genotype 1 panels. Little is known about the...
Sarrazin, Christoph, Hendricks, David A., Sedarati, Farhad, Zeuzem, Stefan
Transcription-mediated amplification (TMA) is an isothermal, autocatalytic target amplification method which has the potential to detect less than 50 hepatitis C virus (HCV) RNA copies/ml (10 IU/ml)....
hMutSα forms an ATP-dependent complex with hMutLα and hMutLβ on DNA
Plotz, Guido, Raedle, Jochen, Brieger, Angela, Trojan, Jörg, Zeuzem, Stefan
The DNA binding properties of hMutSα and hMutLα and complex formation of hMutSα with hMutLα and hMutLβ were investigated using binding experiments on magnetic bead-coupled DNA substrates with...
Sarrazin, Christoph, Herrmann, Eva, Bruch, Katharina, Zeuzem, Stefan
Presumably due to the capability of the hepatitis C virus (HCV) to evade the antiviral effects of alpha interferon, treatment is ineffective in more than half of chronically genotype HCV type 1...
N-terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα
Plotz, Guido, Raedle, Jochen, Brieger, Angela, Trojan, Jörg, Zeuzem, Stefan
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2-hMSH6) and hMutLα...
Epac Activation Converts cAMP from a Proliferative into a Differentiation Signal in PC12 CellsD⃞
Kiermayer, Simone, Biondi, Ricardo M., Imig, Jochen, Plotz, Guido, Haupenthal, Jörg, Zeuzem, Stefan, ...
Elevation of the intracellular cAMP concentration ([cAMP]i) regulates metabolism, cell proliferation, and differentiation and plays roles in memory formation and neoplastic growth. cAMP mediates its...
Sarrazin, Christoph, Gärtner, Barbara C., Sizmann, Dorothea, Babiel, Rainer, Mihm, Ulrike, Hofmann, Wolf Peter, ...
The key parameter for diagnosis and management of hepatitis C virus (HCV) infection is HCV RNA. Standardization of HCV RNA assays to IU is mainly based on genotype 1 panels. Little is known about the...
Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair
Plotz, Guido, Welsch, Christoph, Giron-Monzon, Luis, Friedhoff, Peter, Albrecht, Mario, Piiper, Albrecht, ...
MutLα, a heterodimer of MLH1 and PMS2, plays a central role in human DNA mismatch repair. It interacts ATP-dependently with the mismatch detector MutSα and assembles and controls further repair...
Allosteric activation of the protein kinase PDK1 with low molecular weight compounds
Engel, Matthias, Hindie, Valerie, Lopez-Garcia, Laura A, Stroba, Adriana, Schaeffer, Francis, Adrian, Iris, ...
Organisms rely heavily on protein phosphorylation to transduce intracellular signals. The phosphorylation of a protein often induces conformational changes, which are responsible for triggering...
Jens Rasenack, Stefan Zeuzem, S. Victor Feinman, E. Jenny Heathcote, Michael Manns, Eric M. Yoshida, ...
Background: Use of unmodified interferon alpha-2a in chronic hepatitis C is associated with impaired health-related quality of life during therapy. Treatment with peginterferon alpha-2a (40kD)...
Welsch, Christoph, Domingues, Francisco S, Susser, Simone, Antes, Iris, Hartmann, Christoph, Mayr, Gabriele, ...
Structural analysis of the inhibitor Telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A shows that mutations at V36 and/or T54 result in impaired interaction with VX-950, explaining...
Mühlberger, Nikolai, Schwarzer, Ruth, Lettmeier, Beate, Sroczynski, Gaby, Zeuzem, Stefan, Siebert, Uwe
Vermehren, Johannes, Kau, Annika, Gärtner, Barbara C., Göbel, Reinhild, Zeuzem, Stefan, Sarrazin, Christoph
Hepatitis C virus (HCV) RNA detection and quantification are the key diagnostic tools for the management of hepatitis C. Commercially available HCV RNA assays are calibrated to the HCV genotype 1...