Stefanie Obermüller

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion (2009)

Smith, Ruben, Bacos, Karl, Fedele, Valentina, Soulet, Denis, Walz, Helena A., Obermüller, Stefanie, ...

Huntington's disease is a severe progressive neurodegenerative disorder caused by a CAG expansion in the IT15 gene, which encodes huntingtin. The disease primarily affects the neostriatum and...

Regulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat {beta}-Cells. (2005)

Macdonald, Patrick E, Obermüller, Stefanie, Vikman, Jenny, Galvanovskis, Juris, Rorsman, Patrik, Eliasson, Lena

Abstract is not available

Selective nucleotide-release from dense-core granules in insulin-secreting cells. (2005)

Obermüller, Stefanie, Lindqvist, Anders, Karanauskaite, Jovita, Galvanovskis, Juris, Rorsman, Patrik, Barg, Sebastian

Abstract is not available

Selective nucleotide-release from dense-core granules in insulin-secreting cells (2005)

Obermüller, Stefanie, Lindqvist, Anders, Karanauskaite, Jovita, Galvanovskis, Juris, Rorsman, Patrik, Barg, Sebastian

Secretory granules of insulin-secreting cells are used to store and release peptide hormones as well as low-molecular-weight compounds such as nucleotides. Here we have compared the rate of...

Temperature-Sensitive Random Insulin Granule Diffusion is a Prerequisite for Recruiting Granules for Release. (2004)

Ivarsson, Rosita, Obermüller, Stefanie, Rutter, Guy A, Galvanovskis, Juris, Renström, Erik

Glucose-evoked insulin secretion exhibits a biphasic time course and is associated with accelerated intracellular granule movement. We combined live confocal imaging of EGFP-labelled insulin granules...

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(V)1.2 Ca(2+) channel null mice. (2003)

Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, ...

Abstract is not available

Recyling der Sauren Lysosomalen Phosphatase ; Eingrenzung der Recycling-vermittelnden Aminosäuresequenz und Untersuchungen möglicher Sortierungsfaktoren, die zur Umsetzung des Recyclings benötigt werden (2000)

Obermüller, Stefanie

Die Lysosomale Saure Phosphatase (LAP) und Lamp1 sind lysosomale Membranproteine, die ein tyrosinhaltiges Sortierungsmotiv in ihrer 19 bzw. 11 Aminosäuren langen zytoplasmatischen Domäne enthalten....

Impaired insulin secretion and glucose tolerance in β cell-selective CaV1.2 Ca2+ channel null mice

Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, ...

Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca2+ resulting from enhanced Ca2+ influx through voltage-gated Ca2+ channels. Mouse β cells express several...

Impaired insulin secretion and glucose tolerance in β cell-selective CaV1.2 Ca2+ channel null mice

Schulla, Verena, Renström, Erik, Feil, Robert, Feil, Susanne, Franklin, Isobel, Gjinovci, Asllan, ...

Insulin is secreted from pancreatic β cells in response to an elevation of cytoplasmic Ca2+ resulting from enhanced Ca2+ influx through voltage-gated Ca2+ channels. Mouse β cells express several...