Sten Eirik W. Jacobsen

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements (2008)

Weischenfeldt, Joachim, Damgaard, Inge, Bryder, David, Theilgaard-Mönch, Kim, Thoren, Lina A., Nielsen, Finn Cilius, ...

Nonsense-mediated mRNA decay (NMD) is a post-transcriptional surveillance process that eliminates mRNAs containing premature termination codons (PTCs). NMD has been hypothesized to impact on several...

Ectopic expression of PAX5 promotes self renewal of bi-phenotypic myeloid progenitors co-expressing myeloid and B-cell lineage associated genes. (2007)

Anderson, Kristina, Rusterholz, Corinne, Mansson, Robert, Jensen, Christina T, Bacos, Karl, Zandi, Sasan, ...

Abstract is not available

Crucial role of FLT3 ligand in immune reconstitution following bone marrow transplantation and high dose chemotherapy. (2007)

Buza-Vidas, Natalija, Cheng, Min, Duarte, Sara, Nozad, Hojjatollah, Jacobsen, Sten Eirik W, Sitnicka, Ewa

Abstract is not available

Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. (2007)

Mansson, Robert, Hultquist, Anne, Luc, Sidinh, Yang, Liping, Anderson, Kristina, Kharazi, Shabnam, ...

Abstract is not available

Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors. (2007)

Sitnicka, Ewa, Buza-Vidas, Natalija, Ahlenius, Henrik, Cilio, Corrado M, Gekas, Christos, Nygren, Jens M, ...

Abstract is not available

Distinct roles of integrins {alpha}6 and {alpha}4 in homing of fetal liver hematopoietic stem and progenitor cells. (2007)

Qian, Hong, Georges-Labouesse, Elisabeth, Nystrom, Alexander, Domogatskaya, Anna, Tryggvason, Karl, Jacobsen, Sten Eirik W, ...

Abstract is not available

The molecular signature of MDS stem cells supports a stem cell origin of 5q- myelodysplastic syndromes. (2007)

Nilsson, Lars, Eden, Patrik, Olsson, Eleonor, Mansson, Robert, Astrand-Grundstrom, Ingbritt, Strombeck, Bodil, ...

Abstract is not available

TSLP-mediated fetal B lymphopoiesis? (2007)

Jensen, Christina T, Kharazi, Shabnam, Boiers, Charlotta, Liuba, Karina, Jacobsen, Sten Eirik W

Abstract is not available.

Involvement of CCR9 at multiple stages of adult T lymphopoiesis. (2007)

Svensson, Marcus, Marsal, Jan, Uronen-Hansson, Heli, Cheng, Min, Jenkinson, William, Cilio, Corrado, ...

Abstract is not available

Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T cell development. (2007)

Jensen, Christina T, Boiers, Charlotta, Kharazi, Shabnam, Lubking, Anna, Ryden, Tobias, Sigvardsson, Mikael, ...

Abstract is not available

Failure of Transplanted Bone Marrow Cells to Adopt a Pancreatic {beta}-Cell Fate. (2006)

Taneera, Jalal, Rosengren, Anders, Renstrom, Erik, Nygren, Jens M, Serup, Palle, Rorsman, Patrik, ...

Abstract is not available

Failure of transdifferentiation of adult hematopoietic stem cells into neurons. (2006)

Roybon, Laurent, Ma, Zhi, Asztely, Fredrik, Fosum, Anna, Jacobsen, Sten Eirik W, Brundin, Patrik, ...

Abstract is not available

Prolonged cell cycle transit is a defining and developmentally conserved hemopoietic stem cell property. (2006)

Nygren, Jens M, Bryder, David, Jacobsen, Sten Eirik W

Abstract is not available

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK. (2006)

Buza-Vidas, Natalija, Antonchuk, Jennifer, Qian, Hong, Månsson, Robert, Luc, Sidinh, Zandi, Sasan, ...

Abstract is not available

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK (2006)

Buza-Vidas, Natalija, Antonchuk, Jennifer, Qian, Hong, Månsson, Robert, Luc, Sidinh, Zandi, Sasan, ...

The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing...

Identification of Lin-Sca1+kit+CD34+Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated recipients. (2005)

Yang, Liping, Bryder, David, Adolfsson, Jorgen, Nygren, Jens, Mansson, Robert, Sigvardsson, Mikael, ...

Abstract is not available

Biosynthetic profiles of neutrophil serine proteases in a human bone marrow-derived cellular myeloid differentiation model. (2005)

Garwicz, Daniel, Lennartsson, Andreas, Jacobsen, Sten Eirik W, Gullberg, Urban, Lindmark, Anders

Abstract is not available

IFN-{gamma} Negatively Modulates Self-Renewal of Repopulating Human Hemopoietic Stem Cells. (2005)

Yang, Liping, Dybedal, Ingunn, Bryder, David, Nilsson, Lars, Sitnicka, Ewa, Sasaki, Yutaka, ...

Abstract is not available

Defining 'stemness': Notch and Wnt join forces? (2005)

Jacobsen, Sten Eirik W

Abstract not available

Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia. (2005)

Castor, Anders, Nilsson, Lars, Astrand-Grundström, Ingbritt, Buitenhuis, Miranda, Ramirez, Carole, Anderson, Kristina, ...

Abstract is not available

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells (2004)

Wang, Lingwei, Jacobsen, Sten Eirik W, Bengtsson, Anders, Erlinge, David

Abstract Background Extracellular nucleotides (ATP, ADP, UTP and UDP) exert a wide range of biological effects in blood cells mediated by multiple ionotropic P2X receptors and G protein-coupled P2Y...

Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. (2004)

Nygren, Jens M, Jovinge, Stefan, Breitbach, Martin, Säwén, Petter, Röll, Wilhelm, Hescheler, Jürgen, ...

Abstract is not available

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells. (2004)

Wang, Lingwei, Jacobsen, Sten Eirik W, Bengtsson, Anders, Erlinge, David

Abstract is not available

Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion. (2004)

Bryder, David, Sasaki, Yutaka, Jacobsen, Sten Eirik W

Abstract is not available

Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression. (2003)

Dybedal, Ingunn, Yang, Liping, Bryder, David, Aastrand-Grundstrom, Ingbritt, Leandersson, Karin, Jacobsen, Sten Eirik W

Abstract is not available

Human CD34+ hematopoietic stem cells capable of multilineage engrafting NOD/SCID mice express flt3: distinct flt3 and c-kit expression and response patterns on mouse and candidate human hematopoietic stem cells. (2003)

Sitnicka, Ewa, Buza-Vidas, Natalija, Larsson, Staffan, Nygren, Jens M, Liuba, Karina, Jacobsen, Sten Eirik W

Abstract is not available

Complementary Signaling through flt3 and Interleukin-7 Receptor {alpha} Is Indispensable for Fetal and Adult B Cell Genesis. (2003)

Sitnicka, Ewa, Brakebusch, Cord, Martensson, Inga-Lill, Svensson, Marcus, Agace, William W., Sigvardsson, Mikael, ...

Abstract is not available

Efficient Oncoretroviral Transduction of Extended Long-Term Culture-Initiating Cells and NOD/SCID Repopulating Cells: Enhanced Reconstitution with Gene-Marked Cells Through an Ex Vivo Expansion Approach. (2002)

BjörgvinsdÓttir, Helga, Bryder, David, Sitnicka, Ewa, Ramsfjell, Veslemøy, De Jong, Ineke, Olsson, Karin, ...

Recent developments of surrogate assays for human hematopoietic stem cells (HSC) have facilitated efforts at improving HSC gene transfer efficiency. Through the use of xenograft transplantation...

Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. (2002)

Nilsson, Lars, Astrand-Grundström, Ingbritt, Anderson, Kristina, Arvidsson, Ingrid, Hokland, Peter, Bryder, David, ...

Clonality studies of mature cells suggest that the primary transformation event in myelodysplastic syndrome (MDS) most frequently occurs in a myeloid-restricted progenitor, a hypothesis supported by...

Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool. (2002)

Sitnicka, Ewa, Bryder, David, Theilgaard-Mönch, Kim, Buza-Vidas, Natalija, Adolfsson, Jörgen, Jacobsen, Sten Eirik W

The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid...

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells

Wang, Lingwei, Jacobsen, Sten Eirik W, Bengtsson, Anders, Erlinge, David

P2 receptor mRNA expression profiles in human lymphocytes, monocytes and CD34+ stem and progenitor cells

Wang, Lingwei, Jacobsen, Sten Eirik W, Bengtsson, Anders, Erlinge, David

Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK

Buza-Vidas, Natalija, Antonchuk, Jennifer, Qian, Hong, Månsson, Robert, Luc, Sidinh, Zandi, Sasan, ...

The role of cytokines as regulators of hematopoietic stem cell (HSC) expansion remains elusive. Herein, we identify thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing...

Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Porse, Bo T., Bryder, David, Theilgaard-Mönch, Kim, Hasemann, Marie S., Anderson, Kristina, Damgaard, Inge, ...

CCAAT/enhancer binding protein (C/EBP)α is a myeloid-specific transcription factor that couples lineage commitment to terminal differentiation and cell cycle arrest, and is found mutated in 9% of...

Complementary Signaling through flt3 and Interleukin-7 Receptor α Is Indispensable for Fetal and Adult B Cell Genesis

Sitnicka, Ewa, Brakebusch, Cord, Martensson, Inga-Lill, Svensson, Marcus, Agace, William W., Sigvardsson, Mikael, ...

Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells...

Self-Renewal of Multipotent Long-Term Repopulating Hematopoietic Stem Cells Is Negatively Regulated by FAS and Tumor Necrosis Factor Receptor Activation

Bryder, David, Ramsfjell, Veslemøy, Dybedal, Ingunn, Theilgaard-Mönch, Kim, Högerkorp, Carl-Magnus, Adolfsson, Jörgen, ...

Multipotent self-renewing hematopoietic stem cells (HSCs) are responsible for reconstitution of all blood cell lineages. Whereas growth stimulatory cytokines have been demonstrated to promote HSC...

Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression

Hansson, Frida, Toporski, Jacek, Månsson, Robert, Johansson, Bertil, Norén-Nyström, Ulrika, Jacobsen, Sten Eirik W, ...

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

Weischenfeldt, Joachim, Damgaard, Inge, Bryder, David, Theilgaard-Mönch, Kim, Thoren, Lina A., Nielsen, Finn Cilius, ...

Nonsense-mediated mRNA decay (NMD) is a post-transcriptional surveillance process that eliminates mRNAs containing premature termination codons (PTCs). NMD has been hypothesized to impact on several...