Modulation of chloride homeostasis by inflammatory mediators in dorsal root ganglion neurons (2008)
Funk, Katharina, Woitecki, Anne, Franjic-Würtz, Christina, Gensch, Thomas, Möhrlen, Frank, Frings, Stephan
Abstract Background Chloride currents in peripheral nociceptive neurons have been implicated in the generation of afferent nociceptive signals, as Cl - accumulation in sensory endings establishes the...
Proteomic Analysis of a Membrane Preparation from Rat Olfactory Sensory Cilia (2008)
Mayer, Ulrich, Ungerer, Nicole, Klimmeck, Daniel, Warnken, Uwe, Schnölzer, Martina, Frings, Stephan, ...
The cilia of mammalian olfactory receptor neurons (ORNs) represent the sensory interface that is exposed to the air within the nasal cavity. The cilia are the site where odorants bind to specific...
Kruger, Wade, Gilbert, Daniel, Hawthorne, Rebecca, Hryciw, Deanne H., Frings, Stephan, Poronnik, Philip, ...
There is a significant clinical need to identify novel ligands with high selectivity and potency for GABA(A), GABA(C) and glycine receptor Cl- channels. Two recently developed, yellow fluorescent...
Kruger, Wade, Gilbert, Daniel, Hawthorne, Rebecca, Hryciw, Deanne H., Frings, Stephan, Poronnik, Philip, ...
There is a significant clinical need to identify novel ligands with high selectivity and potency for GABA(A), GABA(C) and glycine receptor Cl- channels. Two recently developed, yellow fluorescent...
Calmodulin Contributes to Gating Control in Olfactory Calcium-activated Chloride Channels
Kaneko, Hiroshi, Möhrlen, Frank, Frings, Stephan
In sensory neurons of the peripheral nervous system, receptor potentials can be amplified by depolarizing Cl currents. In mammalian olfactory sensory neurons (OSNs), this anion-based signal...
The Ca-activated Cl Channel and its Control in Rat Olfactory Receptor Neurons
Reisert, Johannes, Bauer, Paul J., Yau, King-Wai, Frings, Stephan
Odorants activate sensory transduction in olfactory receptor neurons (ORNs) via a cAMP-signaling cascade, which results in the opening of nonselective, cyclic nucleotide–gated (CNG) channels. The...
Frings, Stephan, Brüll, Nicole, Dzeja, Claudia, Angele, Albert, Hagen, Volker, Kaupp, U. Benjamin, ...
In this study, we describe two splice variants of an ether-à-go-go (EAG) K+ channel cloned from bovine retina: bEAG1 and bEAG2. The bEAG2 polypeptide contains an additional insertion of 27 amino...
Ohyama, Tsuyoshi, Hackos, David H., Frings, Stephan, Hagen, Volker, Kaupp, U. Benjamin, Korenbrot, Juan I.
The selectivity for Ca2+ over Na+, PCa/PNa, is higher in cGMP-gated (CNG) ion channels of retinal cone photoreceptors than in those of rods. To ascertain the physiological significance of this fact,...