Stephane Heymans

Focal myocardial fibrosis detected with magnetic resonance late Gadolinium enhancement imaging and diffuse interstitial fibrosis determined with histological staining of endomyocardial biopsy specimens in patients with non-ischemic left ventricular systolic dysfunction: two distinct entities? (2009)

Schalla, Simon, Bekkers, Sebastiaan, Dennert, Robert, Van Suylen, Robert J, Waltenberger, Johannes, Leiner, Tim, ...

No abstract available.

Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction (2009)

Cleutjens, Jack, Debets, Jacques, Van Leeuwen, Rick, ...

The matricellular protein SPARC (secreted protein, acidic and rich in cysteine, also known as osteonectin) mediates cell-matrix interactions during wound healing and regulates the production and/or...

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology (2009)

Heymans, Stephane, Hirsch, Emilio, Anker, Stefan D., Aukrust, Pal, Balligand, Jean-Luc, Cohen-Tervaert, Jan W., ...

The increasing prevalence of heart failure poses enormous challenges for health care systems worldwide. Despite effective medical interventions that target neurohumoral activation, mortality and...

Acute viral myocarditis (2008)

Dennert, Robert, Crijns, Harry J., Heymans, Stephane

Acute myocarditis is one of the most challenging diagnosis in cardiology. At present, no diagnostic gold standard is generally accepted, due to the insensitivity of traditional diagnostic tests. This...

Factor XIII: the cement of the heart after myocardial infarction? (2008)

Vanhoutte, Davy, Heymans, Stephane

How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology (2007)

Paulus, Walter J., Tschöpe, Carsten, Sanderson, John E., Rusconi, Cesare, Flachskampf, Frank A., Rademakers, Frank E., ...

Diastolic heart failure (DHF) currently accounts for more than 50% of all heart failure patients. DHF is also referred to as heart failure with normal left ventricular (LV) ejection fraction (HFNEF)...

Myocarditis and heart failure: need for better diagnostic, predictive, and therapeutic tools (2007)

Heymans, Stephane

Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. (2007)

Fisch, Sudeshna, Gray, Susan, Heymans, Stephane, Haldar, Saptarsi M., Wang, Baiqiu, Pfister, Otmar, ...

Cardiac hypertrophy is a common response to injury and hemodynamic stress and an important harbinger of heart failure and death. Herein, we identify the Kruppel-like factor 15 (KLF15) as an inhibitor...

Annexin A5 and the failing heart; lost or found in translation? (2007)

Hofstra, Leonard, Heymans, Stephane

Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: A temporal and spatial window (2006)

Vanhoutte, Davy, Schellings, Mark, Pinto, Yigal, Heymans, Stephane

The post-myocardial infarction wound repair process involves temporarily overlapping phases that include inflammation, formation of granulation tissue, scar formation, and overall left ventricle (LV)...

Increased cardiac expression of TIMP-1 and TIMP-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart (2005)

Heymans, Stephane; U0011145, Schroen, B, Vermeersch, Pieter; U0035259, Milting, H, Herijgers, Paul; U0010444, Carmeliet, Peter; U0021003, ...

Increased cardiac expression of TIMP-1 and TIMP-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart (2005)

Heymans, Stephane; U0011145, Schroen, B, Milting, H, Herijgers, Paul; U0010444, Carmeliet, Peter; U0021003, Van De Werf, Frans; U0009589, ...

Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart (2005)

Heymans, Stephane; U0011145, Schroen, B, Vermeersch, Pieter; U0035259, Milting, H, Gao, FY, Kassner, A, ...

Background - Alterations in the balance of matrix metalloproteinases ( MMPs) and their specific tissue inhibitors (TIMPs) are involved in left ventricular (LV) remodeling. Whether their expression is...

Matricellular proteins in the heart: possible role during stress and remodeling (2004)

Schellings, Mark W.M., Pinto, Yigal M., Heymans, Stephane

Matricellular proteins are extracellular matrix proteins that modulate cell–matrix interactions and cell function, and do not seem to have a direct structural role. The family includes tenascin-C...

Loss or Inhibition of uPA or MMP-9 Attenuates LV Remodeling and Dysfunction after Acute Pressure Overload in Mice

Heymans, Stephane, Lupu, Florea, Terclavers, Sven, Vanwetswinkel, Bjorn, Herbert, Jean-Marc, Baker, Andrew, ...

Left ventricular (LV) hypertrophy is a natural response of the heart to increased pressure loading, but accompanying fibrosis and dilatation may result in irreversible life-threatening heart failure....

Disruption of the Plasminogen Gene in Mice Abolishes Wound Healing after Myocardial Infarction

Creemers, Esther, Cleutjens, Jack, Smits, Jos, Heymans, Stephane, Moons, Lieve, Collen, Désiré, ...

The plasminogen system plays an important role in the proteolytic degradation of extracellular matrices during wound healing. In the present study we investigated the impact of the plasminogen system...

Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy

Fisch, Sudeshna, Gray, Susan, Heymans, Stephane, Haldar, Saptarsi M., Wang, Baiqiu, Pfister, Otmar, ...

Cardiac hypertrophy is a common response to injury and hemodynamic stress and an important harbinger of heart failure and death. Herein, we identify the Kruppel-like factor 15 (KLF15) as an inhibitor...

Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

Schroen, Blanche, Leenders, Joost J., Van Erk, Arie, Bertrand, Anne T., Van Loon, Mirjam, Van Leeuwen, Rick E., ...

The intercalated disc (ID) of cardiac myocytes is emerging as a crucial structure in the heart. Loss of ID proteins like N-cadherin causes lethal cardiac abnormalities, and mutations in ID proteins...

Acute viral myocarditis

Dennert, Robert, Crijns, Harry J., Heymans, Stephane

Acute myocarditis is one of the most challenging diagnosis in cardiology. At present, no diagnostic gold standard is generally accepted, due to the insensitivity of traditional diagnostic tests. This...

Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction

Schellings, Mark W.M., Vanhoutte, Davy, Swinnen, Melissa, Cleutjens, Jack P., Debets, Jacques, ...

The matricellular protein SPARC (secreted protein, acidic and rich in cysteine, also known as osteonectin) mediates cell–matrix interactions during wound healing and regulates the production and/or...