Stephen A. Wootton

Antiretroviral therapy with or without protease inhibitors impairs postprandial TAG hydrolysis in HIV-infected men (2009)

Ware, Lisa J., Jackson, Akil G.A., Wootton, Stephen A., Burdge, Graham C., Morlese, John F., Moyle, Graeme J., ...

Mechanisms underlying the lipodystrophy syndrome associated with antiretroviral therapy (ART) for HIV infection are not completely understood. We investigated the effect of ART on blood lipid...

Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state (2007)

Heath, Richard B., Karpe, Fredrik, Milne, Ross W., Burdge, Graham C., Wootton, Stephen A., Frayn, Keith N.

Exaggerated postprandial lipemia is associated with coronary heart disease and type II diabetes, yet few studies have examined the effect of sequential meals on lipoprotein metabolism. We have used...

Professional regulation of nutritionists: where are we now? (2007)

Landman, Jacqueline P., Wootton, Stephen A.

Waterlow's (1981) Sixth Boyd Orr Lecture on a 'crisis of identity for nutrition' stimulated the Nutrition Society's drive to professionalisation. Twenty-five years on, the Society begins a new stage;...

Percentage of body fat and plasma glucose predict plasma sialic acid concentration in type 2 diabetes mellitus (2006)

Englyst, Nicola A., Crook, Martin A., Lumb, Peter, Stears, Anna J., Masding, Michael G., Wootton, Stephen A., ...

Circulating sialic acid is an independent risk factor for cardiovascular disease and is higher in people with type 2 diabetes mellitus. Sialic acid is associated with body mass index, but it is...

Variation in [U-C-13] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula (2006)

Mayes, Clifford, Burdge, Graham C., Bingham, Anne, Murphy, Jane L., Tubman, Richard, Wootton, Stephen A.

Docosahexaenoic acid (DHA) is an integral component of neural cell membranes and is critical to the development and function of the CNS. A premature delivery interrupts normal placental supply of DHA...

Percentage of body fat and plasma glucose predict plasma sialic acid concentration in type 2 diabetes mellitus (2006)

Englyst, Nicola A., Crook, Martin A., Lumb, Peter, Stears, Anna J., Masding, Michael G., Wootton, Stephen A., ...

Circulating sialic acid is an independent risk factor for cardiovascular disease and is higher in people with type 2 diabetes mellitus. Sialic acid is associated with body mass index, but it is...

Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study (2006)

Burdge, Graham C., Sherman, Rachel C., Ali, Zulaika, Wootton, Stephen A., Jackson, Alan A.

The fetal demand for docosahexaenoic acid (DHA) has to be satisfied by the mother. We determined the fatty acids in maternal plasma non-esterified fatty acid (NEFA), triacylglycerol (TAG) and...

High-dose fish oil and antioxidants in Crohn's disease and the response of bone turnover: a randomised controlled trial (2005)

Trebble, Timothy M., Stroud, Mike A., Wootton, Stephen A., Calder, Philip C., Fine, David R., Mullee, Mark A., ...

Crohn's disease is associated with altered bone turnover that may be influenced by nutritional status, the systemic inflammatory response, cytokine production by circulating (peripheral blood)...

High-dose fish oil and antioxidants in Crohn's disease and the response of bone turnover: a randomised controlled trial (2005)

Trebble, Timothy M., Stroud, Mike A., Wootton, Stephen A., Calder, Philip C., Fine, David R., Mullee, Mark A., ...

Crohn's disease is associated with altered bone turnover that may be influenced by nutritional status, the systemic inflammatory response, cytokine production by circulating (peripheral blood)...

Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease (2004)

Trebble, Timothy M., Arden, Nigel K., Wootton, Stephen A., Calder, Philip C., Mullee, Mark A., Fine, David R., ...

Background: Crohn disease (CD) is associated with osteoporosis and other extraintestinal manifestations that might be mediated by cytokines from circulating (peripheral blood) mononuclear cells...

Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease (2004)

Trebble, Timothy M., Arden, Nigel K., Wootton, Stephen A., Calder, Philip C., Mullee, Mark A., Fine, David R., ...

BACKGROUND: Crohn disease (CD) is associated with osteoporosis and other extraintestinal manifestations that might be mediated by cytokines from circulating (peripheral blood) mononuclear cells...

Peripheral blood mononuclear cell fatty acid composition and inflammatory mediator production in adult Crohn's disease (2004)

Trebble, Timothy M., Arden, Nigel K., Wootton, Stephen A., Mullee, Mark A., Calder, Philip C., Burdge, Graham C., ...

Background & aims: Crohn's disease (CD) is associated with nutritional deficiencies, altered plasma concentrations of polyunsaturated fatty acids (PUFA) and an anti-inflammatory response to fish oil...

Transfer of (15)N from oral lactose-ureide to lysine in normal adults (2004)

Jackson, Alan A., Gibson, Neil R., Bundy, Rafe, Hounslow, Angela, Millward, D. Joe, Wootton, Stephen A.

The metabolic fate of salvaged urea-nitrogen was explored in normal adults who had consumed a diet that provided 36 g protein/day for 7 days. We hypothesised that the colonic microflora utilise...

Premenopausal advantages in postprandial lipid metabolism are lost in women with type 2 diabetes (2003)

Masding, Michael G., Stears, Anna J., Burdge, Graham C., Wootton, Stephen A., Sandeman, Derek D.

Objective: Women with type 2 diabetes appear to lose the protection against cardiovascular disease afforded by estrogens. We examined the effects of menopausal status on postprandial clearance of...

Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation (2003)

Trebble, Timothy M., Wootton, Stephen A., Miles, Elizabeth A., Mullee, Mark, Arden, Nigel K., Ballinger, Anne B., ...

Background: prostaglandin E2 (PGE2) inhibits lymphocyte proliferation and the production of interferon-{gamma} (IFN-{gamma}) by peripheral blood mononuclear cells, but the effect of PGE2 on...

Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation (2003)

Trebble, Timothy M., Wootton, Stephen A., Miles, Elizabeth A., Mullee, Mark, Arden, Nigel K., Ballinger, Anne B., ...

BACKGROUND: Prostaglandin E(2) (PGE(2)) inhibits lymphocyte proliferation and the production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells, but the effect of PGE(2) on...

Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation1,2,3 (2003)

Trebble, Timothy M., Wootton, Stephen A., Miles, Elizabeth A., Mullee, Mark, Arden, Nigel K., Ballinger, Anne B., ...

BACKGROUND: Prostaglandin E(2) (PGE(2)) inhibits lymphocyte proliferation and the production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells, but the effect of PGE(2) on...

Chylomicron particle size and number, factor VII activation and dietary monounsaturated fatty acids (2003)

Kelly, Colette N.M., Jones, Amanda E., Smith, Ruth D., Wootton, Stephen A., Miller, George J., ...

This study evaluated the effects of substituting dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) on postprandial chylomicron (triacylglycerol (TAG), apolipoprotein B-48...

Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period (2003)

Heath, Richard B., Karpe, Fredrik, Milne, Ross W., Burdge, Graham C., Wootton, Stephen A., Frayn, Keith N.

Circulating triacylglycerol (TG) arises mainly from dietary fat. However, little is known about the entry of dietary fat into the major TG pool, very low-density lipoprotein (VLDL) TG. We used a...

Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle (2002)

Evans, Kevin, Burdge, Graham C., Wootton, Stephen A., Clark, Mo L., Frayn, Keith N.

Using stable isotopic labeling of dietary fatty acids in conjunction with arteriovenous difference measurements, we have assessed the regulation of lipoprotein lipase-derived fatty acid entrapment in...

Effects of prior moderate exercise on exogenous and endogenous lipid metabolism and plasma factor VII activity (2001)

Gill, Jason M., Frayn, Keith N., Wootton, Stephen A., Miller, George J., Hardman, Adrianne E.

Moderate exercise reduces postprandial triacylglycerol concentrations, which are a risk marker for coronary heart disease. The present study sought to determine the qualitative nature of...