Stephen D. Bentley

The complete genome, comparative and functional analysis of Stenotrophomonas maltophiliareveals an organism heavily shielded by drug resistance determinants (2008)

Crossman, Lisa C, Gould, Virginia C, Dow, J Maxwell, Vernikos, Georgios S, Okazaki, Aki, Sebaihia, Mohammed, ...

Abstract Background Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil environments in addition to...

Re-annotation and re-analysis of the Campylobacter jejuniNCTC11168 genome sequence (2007)

Gundogdu, Ozan, Bentley, Stephen D, Holden, Matt T, Parkhill, Julian, Dorrell, Nick, Wren, Brendan W

Abstract Background Campylobacter jejuni is the leading bacterial cause of human gastroenteritis in the developed world. To improve our understanding of this important human pathogen, the C. jejuni...

Meningococcal Genetic Variation Mechanisms Viewed through Comparative Analysis of Serogroup C Strain FAM18 (2007)

Stephen D. Bentley, George S. Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...

The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...

Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18 (2007)

Bentley, Stephen D., Vernikos, George S., Snyder, Lori A. S., Churcher, Carol, Arrowsmith, Claire, Chillingworth, Tracey, ...

The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...

Comparative genomic view of mechanisms of variation in Neisseria meningitidis through sequencing and analysis of a third meningococcal genome from serogroup C strain FAM18 (2006)

Stephen D. Bentley, George Vernikos, Carol Churcher, Claire Arrowsmith, Tracey Chillingworth, ...

The bacterium, Neisseria meningitidis, is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...

Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes (2006)

Stephen D. Bentley, David M. Aanensen, Angeliki Mavroidi, David Saunders, Ester Rabbinowitsch, Matthew Collins, ...

Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host...

Bioinformatic identification of novel regulatory DNA sequence motifs in Streptomyces coelicolor (2004)

Studholme, David J, Bentley, Stephen D, Kormanec, Jan

Abstract Background Streptomyces coelicolor is a bacterium with a vast repertoire of metabolic functions and complex systems of cellular development. Its genome sequence is rich in genes that encode...

Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica (2003)

Parkhill,Julian, Sebaihia,Mohammed, Preston,Andrew, Murphy,Lee D., Thomson,Nicholas, Harris,David E., ...

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are closely related Gram-negative -proteobacteria that colonize the respiratory tracts of mammals. B. pertussis is a...

Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance

Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...

Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation

Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...

The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...

Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes

Bentley, Stephen D, Aanensen, David M, Mavroidi, Angeliki, Saunders, David, Rabbinowitsch, Ester, Collins, Matthew, ...

Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host...

Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance

Holden, Matthew T. G., Feil, Edward J., Lindsay, Jodi A., Peacock, Sharon J., Day, Nicholas P. J., Enright, Mark C., ...

Staphylococcus aureus is an important nosocomial and community-acquired pathogen. Its genetic plasticity has facilitated the evolution of many virulent and drug-resistant strains, presenting a major...

Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei

Holden, Matthew T. G., Titball, Richard W., Peacock, Sharon J., Cerdeño-Tárraga, Ana M., Atkins, Timothy, Crossman, Lisa C., ...

Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world...

The Chlamydophila abortus genome sequence reveals an array of variable proteins that contribute to interspecies variation

Thomson, Nicholas R., Yeats, Corin, Bell, Kenneth, Holden, Matthew T.G., Bentley, Stephen D., Livingstone, Morag, ...

The obligate intracellular bacterial pathogen Chlamydophila abortus strain S26/3 (formerly the abortion subtype of Chlamydia psittaci) is an important cause of late gestation abortions in ruminants...

Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes

Bentley, Stephen D, Aanensen, David M, Mavroidi, Angeliki, Saunders, David, Rabbinowitsch, Ester, Collins, Matthew, ...

Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host...

Meningococcal Genetic Variation Mechanisms Viewed through Comparative Analysis of Serogroup C Strain FAM18

Bentley, Stephen D, Vernikos, George S, Snyder, Lori A. S, Churcher, Carol, Arrowsmith, Claire, Chillingworth, Tracey, ...

The bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx. Occasionally strains can invade host tissues causing septicaemia and...

Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes

Sebaihia, Mohammed, Peck, Michael W., Minton, Nigel P., Thomson, Nicholas R., Holden, Matthew T.G., Mitchell, Wilfrid J., ...

Clostridium botulinum is a heterogeneous Gram-positive species that comprises four genetically and physiologically distinct groups of bacteria that share the ability to produce botulinum neurotoxin,...

Comparative Genomic Analyses of Seventeen Streptococcus pneumoniae Strains: Insights into the Pneumococcal Supragenome▿ †

Hiller, N. Luisa, Janto, Benjamin, Hogg, Justin S., Boissy, Robert, Yu, Susan, Powell, Evan, ...

The distributed-genome hypothesis (DGH) states that pathogenic bacteria possess a supragenome that is much larger than the genome of any single bacterium and that these pathogens utilize genetic...

Genetic Relatedness of the Streptococcus pneumoniae Capsular Biosynthetic Loci▿ †

Mavroidi, Angeliki, Aanensen, David M., Godoy, Daniel, Skovsted, Ian C., Kaltoft, Margit S., Reeves, Peter R., ...

Streptococcus pneumoniae (the pneumococcus) produces 1 of 91 capsular polysaccharides (CPS) that define the serotype. The cps loci of 88 pneumococcal serotypes whose CPS is synthesized by the...

Predicted Functions and Linkage Specificities of the Products of the Streptococcus pneumoniae Capsular Biosynthetic Loci▿ †

Aanensen, David M., Mavroidi, Angeliki, Bentley, Stephen D., Reeves, Peter R., Spratt, Brian G.

The sequences of the capsular biosynthetic (cps) loci of 90 serotypes of Streptococcus pneumoniae have recently been determined. Bioinformatic procedures were used to predict the general functions of...

Genome of the Actinomycete Plant Pathogen Clavibacter michiganensis subsp. sepedonicus Suggests Recent Niche Adaptation▿ †

Bentley, Stephen D., Corton, Craig, Brown, Susan E., Barron, Andrew, Clark, Louise, Doggett, Jon, ...

Clavibacter michiganensis subsp. sepedonicus is a plant-pathogenic bacterium and the causative agent of bacterial ring rot, a devastating agricultural disease under strict quarantine control and zero...