Mouse Taste Buds Release Serotonin in Response to Taste Stimuli (2005)
Huang, Yi-Jen, Maruyama, Yutaka, Lu, Kuo-Shyan, Pereira, Elizabeth, Roper, Stephen D.
PLC{beta}2-Independent Behavioral Avoidance of Prototypical Bitter-Tasting Ligands (2005)
Dotson, Cedrick D., Roper, Stephen D., Spector, Alan C.
Using a brief-access taste assay, we show in the present report that although phospholipase C β2 knockout (PLCβ2 KO) mice are unresponsive to low- and midrange concentrations of quinine and...
Rat Gustatory Neurons in the Geniculate Ganglion Express Glutamate Receptor Subunits (2004)
Caicedo, Alejandro, Zucchi, Benedetta, Pereira, Elizabeth, Roper, Stephen D.
Taste receptor cells are innervated by primary gustatory neurons that relay sensory information to the central nervous system. The transmitter(s) at synapses between taste receptor cells and primary...
Corey, David P, Roper, Stephen D
Incluye bibliografía e índice
Isolation of single taste cells from lingual epithelium (1988)
Kinnamon, Sue C., Cummings, Thomas A., Roper, Stephen D.
A method is described for obtaining large numbers of isolated taste cells with identified polarity from lingual epithelium. The procedure involves incubating lingual epithelium in collagenase,...
Kinnamon, Sue C., Roper, Stephen D.
The taste stimulus KCl is transduced in mudpuppy taste cells by a voltage-sensitive K+ conductance on the apical membrane. Sour taste stimuli produce depolarizing receptor potentials by blocking...
Amiloride does not block taste transduction in the mudpuppy, Necturus maculosus (1985)
McPheeters, Martha, Roper, Stephen D.
Activity of the glossopharyngeal nerve was recorded with bipolar silver wire electrodes while taste stimuli were applied to the lingual surface in anesthetized mudpuppies. Taste stimuli were injected...
The role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds
Huang, Yi-Jen, Maruyama, Yutaka, Dvoryanchikov, Gennady, Pereira, Elizabeth, Chaudhari, Nirupa, Roper, Stephen D.
ATP has been shown to be a taste bud afferent transmitter, but the cells responsible for, and the mechanism of, its release have not been identified. Using CHO cells expressing high-affinity...
Individual mouse taste cells respond to multiple chemical stimuli
Caicedo, Alejandro, Kim, Kyung-Nyun, Roper, Stephen D
Sensory organs are specialized to detect and decode stimuli in terms of intensity and quality. In the gustatory system, the process of identifying and distinguishing taste qualities (e.g. bitter...
Imaging Cyclic AMP Changes in Pancreatic Islets of Transgenic Reporter Mice
Kim, Joung Woul, Roberts, Craig D., Berg, Stephanie A., Caicedo, Alejandro, Roper, Stephen D., Chaudhari, Nirupa
Cyclic AMP (cAMP) and Ca2+ are two ubiquitous second messengers in transduction pathways downstream of receptors for hormones, neurotransmitters and local signals. The availability of fluorescent...
Anselmi, Fabio, Hernandez, Victor H., Crispino, Giulia, Seydel, Anke, Ortolano, Saida, Roper, Stephen D., ...
Extracellular ATP controls various signaling systems including propagation of intercellular Ca2+ signals (ICS). Connexin hemichannels, P2x7 receptors (P2x7Rs), pannexin channels, anion channels,...