Neafsey, Daniel E, Schaffner, Stephen F, Volkman, Sarah K, Park, Daniel, Montgomery, Philip, Milner, Danny A, ...
Abstract Background The malaria parasite Plasmodium falciparum exhibits abundant genetic diversity, and this diversity is key to its success as a pathogen. Previous efforts to study genetic diversity...
A second generation human haplotype map of over 3.1 million SNPs (2007)
Frazer, Kelly A., Ballinger, Dennis G., Cox, David R., Hinds, David A., Stuve, Laura L., Gibbs, Richard A., ...
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and...
Initial sequence of the chimpanzee genome and comparison with the human genome (2005)
Mikkelsen, Tarjei S., Hillier, LaDeana W., Eichler, Evan E., Zody, Michael C., Jaffe, David B., Yang, Shiaw-Pyng, ...
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences...
Calibrating a coalescent simulation of human genome sequence variation (2005)
Schaffner, Stephen F., Foo, Catherine, Gabriel, Stacey, Reich, David, Daly, Mark J., Altshuler, David
Population genetic models play an important role in human genetic research, connecting empirical observations about sequence variation with hypotheses about underlying historical and biological...
Hirschhorn, Joel N., Lindgren, Cecilia M., Daly, Mark J., Kirby, Andrew, Schaffner, Stephen F., Burtt, Noel P., ...
Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common...
Calibrating a coalescent simulation of human genome sequence variation
Schaffner, Stephen F., Foo, Catherine, Gabriel, Stacey, Reich, David, Daly, Mark J., Altshuler, David
Population genetic models play an important role in human genetic research, connecting empirical observations about sequence variation with hypotheses about underlying historical and biological...
An Integrated Haplotype Map of the Human Major Histocompatibility Complex
Walsh, Emily C., Mather, Kristie A., Schaffner, Stephen F., Farwell, Lisa, Daly, Mark J., Patterson, Nick, ...
Numerous studies have clearly indicated a role for the major histocompatibility complex (MHC) in susceptibility to autoimmune diseases. Such studies have focused on the genetic variation of a small...
Hirschhorn, Joel N., Lindgren, Cecilia M., Daly, Mark J., Kirby, Andrew, Schaffner, Stephen F., Burtt, Noel P., ...
Genomewide linkage analysis has been extremely successful at identification of the genetic variation underlying single-gene disorders. However, linkage analysis has been less successful for common...
Calibrating a coalescent simulation of human genome sequence variation
Schaffner, Stephen F., Foo, Catherine, Gabriel, Stacey, Reich, David, Daly, Mark J., Altshuler, David
Population genetic models play an important role in human genetic research, connecting empirical observations about sequence variation with hypotheses about underlying historical and biological...
Neafsey, Daniel E, Schaffner, Stephen F, Volkman, Sarah K, Park, Daniel, Montgomery, Philip, Milner, Danny A, ...
An array-based SNP genotyping platform for Plasmodium falciparum is reported together with an analysis of SNP diversity in global population samples.