Stephen J. Clarke

Eligibility of patients with advanced non-small cell lung cancer for phase III chemotherapy trials (2009)

Vardy, Janette, Dadasovich, Ryan, Beale, Philip, Boyer, Michael, Clarke, Stephen J

Abstract Background Evidence that chemotherapy improves survival and quality of life in patients with stage IIIB & IV non small cell lung cancer (NSCLC) is based on large randomized controlled...

The Development of multiple reaction monitoring assays for liver-derived plasma proteins (2007)

Mckay, Matthew J, Sherman, Jamie, Laver, Matthew T, Baker, Mark S, Clarke, Stephen J, Molloy, Mark P

There is wide interpatient variability in toxicity to chemotherapeutic drugs and a lack of routine clinical tests for prospectively identifying patients at risk of developing toxicity from...

Clinical pharmacokinetics of the irinotecan metabolite 4-piperidinopiperidine and its possible clinical importance (2000)

Dodds, Helen M., Clarke, Stephen J., Findlay, Michael, Bishop, James F., Robert, Jacques, Rivory, Laurent P.

Purpose: To investigate the clinical relevance of 4-piperidinopiperidine (4PP) in the activity of irinotecan (CPT-11), a high-performance liquid chromatography-turboionspray-tandem mass spectrometry...

Clinical pharmacokinetics of the irinotecan metabolite 4-piperidinopiperidine and its possible clinical importance (2000)

Dodds, Helen M., Clarke, Stephen J., Findlay, Michael, Bishop, James F., Robert, Jacques, Rivory, Laurent P.

Purpose: To investigate the clinical relevance of 4-piperidinopiperidine (4PP) in the activity of irinotecan (CPT-11), a high-performance liquid chromatography-turboionspray-tandem mass spectrometry...

A novel approach to investigate the subcellular distribution of nuclear receptors in vivo

Matic, Marko, Nakhel, Sarah, Lehnert, Anne M., Polly, Patsie, Clarke, Stephen J., Robertson, Graham R.

Subcellular compartmentalisation and the intracellular movement of nuclear receptors are major regulatory steps in executing their transcriptional function. Though significant progress has been made...