Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus? (2009)
Turner, Stephen J, Brown, Lorena E, Doherty, Peter C, Kelso, Anne
No abstract available.
Q&A: What do we know about influenza and what can we do about it? (2009)
Doherty, Peter C, Turner, Stephen J
No abstract available.
Bu-sung Lee, Wentong Cai, Stephen J. Turner, L. Chen
Abstract: This paper describes two adaptive algorithms for dead reckoning in Distributed Interactive Simulation (DIS). The first algorithm is based on the control mechanism of adaptive adjustment of...
Flexible State Update Mechanism for Large-Scale Distributed Wargame Simulations (2008)
Suiping Zhou, Wentong Cai, Stephen J. Turner, Junhu Wei, Wenbo Zong, Suiping Zhou, ...
On behalf of:
Gualano, Rosa C, Hansen, Michelle J, Vlahos, Ross, Jones, Jessica E, Park-Jones, Ruth A, Deliyannis, Georgia, ...
Abstract Background Cigarette smoke has both pro-inflammatory and immunosuppressive effects. Both active and passive cigarette smoke exposure are linked to an increased incidence and severity of...
S. G. Henderson, B. Biller, J. Shortle, J. D. Tew, R. R. Barton, ...
In today’s highly competitive business environment, the speed of a company’s response to changes by adapting its own business processes is vital to its survival. In this paper, we propose a...
Nanyang Technological University (2008)
Dan Chen, Stephen J. Turner, Wentong Cai, Boon Ping Gan, Malcolm Yoke, Hean Low
Distributed simulation cloning technology is designed to analyze alternative scenarios of a distributed simulation concurrently within the same execution session. One important goal is to optimize...
M. E. Kuhl, N. M. Steiger, F. B. Armstrong, J. A. Joines, Peter Lendermann, Malcolm Yoke, ...
This article describes the results of one of the ten pilot programmes under the Integrated Manufacturing and Service Systems (IMSS) initiative pursued by the Agency for Science, Technology and...
Critical Causal Order of Events in Distributed Virtual Environments (2008)
Suiping Zhou, Wentong Cai, Stephen J. Turner, Bu-sung Lee, Junhu Wei
We investigate the causal order of events in distributed virtual environments (DVEs). We first define the critical causal order relation among the events. Then, we propose some mechanisms to enhance...
Time-Space Consistency in Large Scale Distributed Virtual Environment (2008)
Suiping Zhou, Wentong Cai, Bu-sung Lee, Stephen J. Turner
Maintaining a consistent view of the simulated world among different simulation nodes is a fundamental problem in large scale distributed virtual environments (DVEs). In this paper, we characterize...
A Parallelizing Compiler and Run Time System based on Optimistic Execution (2007)
Adam Back Stephen, Stephen J. Turner
Most parallelizing compilers to date have been based broadly on compile-time data flow analysis. This reliance on static information imposes an overly restrictive view of the parallelism available in...
A Parallelizing Compiler and Run Time System based on Optimistic Execution (2007)
Most parallelizing compilers to date have been based broadly on compile-time data flow analysis. This reliance on static information imposes an overly restrictive view of the parallelism available in...
Harnessing Parallelism in a Parallel Discrete-Event Simulation (2007)
Chu-cheow Lim, Yoke-hean Low, Boon-ping Gan, Sanjay Jain, Stephen J. Turner, ...
This paper looks at a parallel discrete-event simulation of wafer fabrication models. This is an irregular computation because when events are sent from one logical process (LP) to another, the...
Optimistic Network Computing and its Performance Control (2007)
Optimistic execution is a powerful technique that can enable an application to make more efficient use of resources that are distributed across a computer network. Such a mechanism may be used to...
Alois Ferscha, James Johnson, Stephen J. Turner
The performance of logical process based distributed simulation (DS) protocols like Time Warp and Chandy/Misra/Bryant is in uenced by a variety of factors such as the event structure underlying in...
Stewart, Claire, Sabin, Matthew A., Holly, Jeff, Shield, Julian, Turner, Stephen J., Grohmann, Malcolm, ...
Full-text of this article is not available in this e-prints service. This article was originally published [following peer-review] in Journal of Clinical Endocrinology and Metabolism, published by...
Stewart, Claire, Sabin, Matthew A., Holly, Jeff, Shield, Julian, Turner, Stephen J., Grohmann, Malcolm, ...
Full-text of this article is not available in this e-prints service. This article was originally published [following peer-review] in Journal of Clinical Endocrinology and Metabolism, published by...
Markovic, Olivera, O'Reilly, Gillian, Fussell, Helen M., Turner, Stephen J., Calder, Philip C., Howell, William M., ...
Background and Aims: Lipid metabolism, obesity and inflammation are intimately related. Plasma triglycerides increase during the inflammatory response to pathogens and obesity increases inflammatory...
Markovic, Olivera, O'Reilly, Gillian, Fussell, Helen M., Turner, Stephen J., Calder, Philip C., Howell, William M., ...
Background and Aims: Lipid metabolism, obesity and inflammation are intimately related. Plasma triglycerides increase during the inflammatory response to pathogens and obesity increases inflammatory...
Grimble, Robert.F., Howell, W.Martin, Reilly, Gillian, Turner, Stephen.J., Markovic, Olivera, Hirrell, Sharon, ...
BACKGROUND: Tumor necrosis factor alpha (TNF-alpha) mediates inflammation. High TNF-alpha production has adverse effects during disease. Polymorphisms in the TNF-alpha and lymphotoxin alpha genes...
Grimble, Robert F., Howell, W. Martin, O’Reilly, Gillian, Turner, Stephen J., Markovic, Olivera, Hirrell, Sharon, ...
Background: Tumor necrosis factor {alpha} (TNF-{alpha}) mediates inflammation. High TNF-{alpha} production has adverse effects during disease. Polymorphisms in the TNF-{alpha} and lymphotoxin {alpha}...
POEMS: A Parallel Object-oriented Environment for Multi-computer Systems (2002)
Jie, Wei, Cai, Wentong, Turner, Stephen J.
POEMS is a Parallel Object-oriented Environment for Multi-computer Systems. In order to support dynamic load balancing, its runtime execution model is based on object replication. Method invocation...
Hierarchical federations: an architecture for information hiding (2001)
Wentong Cai, Stephen J. Turner, Boon Ping Gan
In a distributed simulation, simulation components of various types are executed at geographically different locations, forming a simulation federation to create a common virtual environment. Under...
A new heuristic for the process-processor mapping problem, in (2000)
Zoltan Juhasz, Stephen J. Turner
This paper describes a new heuristic for the n-process p-processor task-assignment problem. The algorithm is based on repeatedly merging pairs of processes in order to reduce the initial n-node task...
A new heuristic for the process-processor mapping problem, in (2000)
Zoltan Juhasz, Stephen J. Turner
Abstract. This paper describes a new heuristic for the n-process p-processor task-assignment problem. The algorithm is based on repeatedly merging pairs of processes in order to reduce the initial...
Distributed Supply Chain Simulation Across Enterprise Boundaries (2000)
Boon Ping Gan, Li Liu, Sanjay Jain, Stephen J. Turner, Wentong Cai, Wen-jing Hsu
The effective practice of supply chain management (SCM) is crucial to improve corporations' competitive advantage. Many corporations have built simulation models to facilitate the application of...
Boon-ping Gan, Stephen J. Turner
The development of parallel simulation technology is seen as an enabler for the implementation of the virtual factory concept, the integrated simulation of all the systems in a factory. One important...
Yoke-hean Low, Chu-cheow Lim, Wentong Cai, Shell-ying Huang, Wen-jing Hsu, Sanjay Jain, ...
On behalf of:
Survey of Languages and Runtime Libraries for Parallel Discrete Event Simulation (1999)
Yoke-Hean Low, Chu-cheow Lim, Wentong Cai, Shell-Ying Huang, Wen-Jing HSU, Sanjay JAIN, ...
To develop a parallel discrete event simulation from scratch requires in-depth knowledge of the mapping process from the physical model to the simulation model and also a substantial effort in coping...
A Parallel Discrete-Event Simulation of Wafer Fabrication Processes (1998)
Chu-cheow Lim, Yoke-hean Low, Boon-ping Gan, Stephen J. Turner, Sanjay Jain, Wentong Cai, ...
Simulation modeling is an important tool for planning factory operations, to identify and eliminate possible bottlenecks and to maintain high machine utilization. The objective of our project is to...
A Methodology for Automating the Parallelization of Manufacturing Simulations (1998)
Stephen J. Turner, Wentong Cai, Chu Cheow Lim, Yoke Hean Low, Wen Jing Hsu, Shell Ying Huang, ...
One of the main reasons why parallel discrete event simulationhas not been adopted more widely in industry is that the terminology used by the parallel simulation community differs from that of...
An Empirical Comparison of Runtime Systems for Conservative Parallel Simulation (1998)
Chu-cheow Lim, Yoke-Hean Low, Wentong Cai, Wen Jing Hsu, Shell Ying Huang, Stephen J. Turner
A main consideration when implementing a parallel simulation application is the choice of the parallel simulation protocol (conservative vs. optimistic). Given a particular protocol, the application...
Conservative Parallel Simulation for Manufacturing Systems (1998)
Yoke-Hean Low, Chu-cheow Lim, Wentong Cai, Wen Jing Hsu, Boon-ping Gan, Sanjay Jain, ...
Manufacturing system simulations have traditionally been executed using sequential simulators. To allow accurate modelling of the fine details in such a complex system requires the simulator to...
Typescript (photocopy)
Dag consistent parallel simulation: A predictable and robust conservative algorithm (1997)
Wentong Cai, Emmanuelle Letertre, Stephen J. Turner
This paper presents a novel approach to parallel discrete event simulation based on a provably efficient scheduler for multithreaded programming. The "Cilk " runtime system provides...
Early Performance Prediction of Parallel Simulation Protocols (1997)
Alois Ferscha James, James Johnson, Stephen J. Turner
The performance of logical process based parallel simulation (PS) protocols like Time Warp and Chandy/Misra/Bryant is influenced by a variety of factors such as the event structure underlying in the...
Dag Consistent Parallel Simulation: a Predictable and Robust Conservative Algorithm (1997)
Wentong Cai, Emmanuelle Letertre, Stephen J. Turner
This paper presents a novel approach to parallel discrete event simulation based on a provably efficient scheduler for multithreaded programming. The "Cilk" runtime system provides the user...
Early Performance Prediction of Parallel Simulation Protocols (1997)
Alois Ferscha, James Johnson, Stephen J. Turner
The performance of logical process based parallel simulation (PS) protocols like Time Warp and Chandy/Misra/Bryant is influenced by a variety of factors such as the event structure underlying in the...
An Algorithm For Reducing Null-Messages of CMB Approach in Parallel Discrete Event Simulation (1995)
Wentong Cai School, Wentong Cai, Stephen J. Turner
this paper, we concentrate on the former. In conservative parallel discrete event simulation, the occurrences of any local causality errors are strictly avoided. The sequence of timestamps on...
An Algorithm For Reducing Null-Messages of CMB Approach in Parallel Discrete Event Simulation (1995)
Wentong Cai, Stephen J. Turner
this paper, we concentrate on the former. In conservative parallel discrete event simulation, the occurrences of any local causality errors are strictly avoided. The sequence of timestamps on...
A T9000 implementation of the p4 parallel programming model (1994)
Abstract. Although parallel computers have significant price/performance advantages over conventional sequential machines, they are still not widely used for general purpose computing. One of the...
A T9000 Implementation of the p4 Parallel Programming Model (1994)
Stephen Turner And, Stephen J. Turner, Adam Back
. Although parallel computers have significant price/performance advantages over conventional sequential machines, they are still not widely used for general purpose computing. One of the main...
An Approach to the Run-Time Monitoring of Parallel Programs (1994)
Wentong Cai, Stephen J. Turner, Telex Exuniv G
: Monitoring is fundamental to both debugging and performance analysis. It can provide dynamic execution information for displaying execution states, and statistical data for evaluating the...
A Generalized Carrier-Null Method for Conservative Parallel Simulation (1994)
Kenneth Wood Programming, Kenneth R. Wood, Stephen J. Turner
The carrier-null message approach to conservative distributed discrete-event simulation can significantly reduce the number of synchronization messages required to avoid deadlock. In this paper we...
An Approach to the Run-Time Monitoring of Parallel Programs (1994)
Wentong Cai, Stephen J. Turner
: Monitoring is fundamental to both debugging and performance analysis. It can provide dynamic execution information for displaying execution states, and statistical data for evaluating the...
Process Scheduling and Program Monitoring on Transputers (1993)
Wentong Cai, Stephen J. Turner
. Parallel program monitoring is a key to success in parallel program development. We have developed a novel approach, called the logical clock approach, for the highly transparent monitoring of...
Process Scheduling and Program Monitoring on Transputers (1993)
Wentong Cai, Stephen J. Turner
. Parallel program monitoring is a key to success in parallel program development. We have developed a novel approach, called the logical clock approach, for the highly transparent monitoring of...
Measuring the diaspora for virus-specific CD8+ T cells
Marshall, Dana R., Turner, Stephen J., Belz, Gabrielle T., Wingo, Suzette, Andreansky, Samita, Sangster, Mark Y., ...
The CD8+ T cell diaspora has been analyzed after secondary challenge with an influenza A virus that replicates only in the respiratory tract. Numbers of DbNP366- and DbPA224-specific CD8+ T cells...
Liu, Haiyan, Andreansky, Samita, Diaz, Gabriela, Turner, Stephen J., Wodarz, Dominik, Doherty, Peter C.
The consequences for the long-term maintenance of virus-specific CD8+-T-cell memory have been analyzed experimentally for sequential respiratory infections with readily eliminated (influenza virus)...
Protection and compensation in the influenza virus-specific CD8+ T cell response
Webby, Richard J., Andreansky, Samita, Stambas, John, Rehg, Jerold E., Webster, Robert G., Doherty, Peter C., ...
Influenza virus-specific CD8+ T cells generally recognize peptides derived from conserved, internal proteins that are not subject to antibody-mediated selection pressure. Prior exposure to any one...
Turner, Stephen J., La Gruta, Nicole L., Stambas, John, Diaz, Gabriela, Doherty, Peter C.
Much of the CD8+ T cell response in H2b mice with influenza pneumonia is directed at the nucleoprotein366-374 (NP366) and acid polymerase224-233 (PA224) peptides presented by the H2Db MHC class I...
Kedzierska, Katherine, Turner, Stephen J., Doherty, Peter C.
The CD8+ T cell response to the immunodominant DbNP366 epitope has been analyzed sequentially to determine the prevalence and persistence of different T cell antigen receptor (TCR)Vβ8.3 clonotypes...
Marshall, Dana R., Olivas, Elvia, Andreansky, Samita, La Gruta, Nicole L., Neale, Geoff A., Gutierrez, Astrid, ...
The restriction of influenza A virus replication to mouse respiratory epithelium means that this host response is anatomically compartmentalized, on the one hand, to sites of T cell stimulation and...
Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses
Kedzierska, Katherine, La Gruta, Nicole L., Davenport, Miles P., Turner, Stephen J., Doherty, Peter C.
Prior analysis has characterized the clonal characteristics of effector CD8+ T cells specific for the prominent influenza A virus nucleoprotein (NP) and acid polymerase (PA) peptides presented by...
La Gruta, Nicole L., Kedzierska, Katherine, Pang, Ken, Webby, Richard, Davenport, Miles, Chen, Weisan, ...
Immunodominance hierarchies are a substantial, but poorly understood, characteristic of CD8+ T cell-mediated immunity. Factors influencing the differential responses to the influenza A virus...
Kedzierska, Katherine, Venturi, Vanessa, Field, Kenneth, Davenport, Miles P., Turner, Stephen J., Doherty, Peter C.
Single-cell analysis of endogenous, primary CD8+ T cell responses to the influenza DbNP366 and DbPA224 epitopes indicates that prominent clonotypes bearing “public” or “shared” T cell...
Measuring the diaspora for virus-specific CD8+ T cells
Marshall, Dana R., Turner, Stephen J., Belz, Gabrielle T., Wingo, Suzette, Andreansky, Samita, Sangster, Mark Y., ...
The CD8+ T cell diaspora has been analyzed after secondary challenge with an influenza A virus that replicates only in the respiratory tract. Numbers of DbNP366- and DbPA224-specific CD8+ T cells...
Liu, Haiyan, Andreansky, Samita, Diaz, Gabriela, Turner, Stephen J., Wodarz, Dominik, Doherty, Peter C.
The consequences for the long-term maintenance of virus-specific CD8+-T-cell memory have been analyzed experimentally for sequential respiratory infections with readily eliminated (influenza virus)...
Protection and compensation in the influenza virus-specific CD8+ T cell response
Webby, Richard J., Andreansky, Samita, Stambas, John, Rehg, Jerold E., Webster, Robert G., Doherty, Peter C., ...
Influenza virus-specific CD8+ T cells generally recognize peptides derived from conserved, internal proteins that are not subject to antibody-mediated selection pressure. Prior exposure to any one...
Turner, Stephen J., La Gruta, Nicole L., Stambas, John, Diaz, Gabriela, Doherty, Peter C.
Much of the CD8+ T cell response in H2b mice with influenza pneumonia is directed at the nucleoprotein366-374 (NP366) and acid polymerase224-233 (PA224) peptides presented by the H2Db MHC class I...
Kedzierska, Katherine, Turner, Stephen J., Doherty, Peter C.
The CD8+ T cell response to the immunodominant DbNP366 epitope has been analyzed sequentially to determine the prevalence and persistence of different T cell antigen receptor (TCR)Vβ8.3 clonotypes...
Marshall, Dana R., Olivas, Elvia, Andreansky, Samita, La Gruta, Nicole L., Neale, Geoff A., Gutierrez, Astrid, ...
The restriction of influenza A virus replication to mouse respiratory epithelium means that this host response is anatomically compartmentalized, on the one hand, to sites of T cell stimulation and...
Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses
Kedzierska, Katherine, La Gruta, Nicole L., Davenport, Miles P., Turner, Stephen J., Doherty, Peter C.
Prior analysis has characterized the clonal characteristics of effector CD8+ T cells specific for the prominent influenza A virus nucleoprotein (NP) and acid polymerase (PA) peptides presented by...
La Gruta, Nicole L., Kedzierska, Katherine, Pang, Ken, Webby, Richard, Davenport, Miles, Chen, Weisan, ...
Immunodominance hierarchies are a substantial, but poorly understood, characteristic of CD8+ T cell-mediated immunity. Factors influencing the differential responses to the influenza A virus...
Kedzierska, Katherine, Venturi, Vanessa, Field, Kenneth, Davenport, Miles P., Turner, Stephen J., Doherty, Peter C.
Single-cell analysis of endogenous, primary CD8+ T cell responses to the influenza DbNP366 and DbPA224 epitopes indicates that prominent clonotypes bearing “public” or “shared” T cell...
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination
Venturi, Vanessa, Kedzierska, Katherine, Price, David A., Doherty, Peter C., Douek, Daniel C., Turner, Stephen J., ...
Public responses where identical T cell receptors (TCRs) are clonally dominant and shared between different individuals are a common characteristic of CD8+ T cell-mediated immunity. Focusing on TCR...
Waterhouse, Nigel J., Sutton, Vivien R., Sedelies, Karin A, Ciccone, Annette, Jenkins, Misty, Turner, Stephen J., ...
Cytotoxic T lymphocyte (CTL)–induced death triggered by the granule exocytosis pathway involves the perforin-dependent delivery of granzymes to the target cell. Gene targeting has shown that...
Kedzierska, Katherine, Stambas, John, Jenkins, Misty R., Keating, Rachael, Turner, Stephen J., Doherty, Peter C.
The rapid recall of influenza virus-specific CD8+ T cell effector function is protective, although our understanding of T cell memory remains incomplete. Recent debate has focused particularly on the...
Crowe, Sherry R., Turner, Stephen J., Miller, Shannon C., Roberts, Alan D., Rappolo, Rachel A., Doherty, Peter C., ...
The specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366–374/Db- and PA224–233/Db-specific CD8+ T cells respond in approximately...
Halasz, Peter, Holloway, Gavan, Turner, Stephen J., Coulson, Barbara S.
Changes in the interactions between intestinal cells and their surrounding environment during virus infection have not been well documented. The growth and survival of intestinal epithelial cells,...
Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice
Gualano, Rosa C, Hansen, Michelle J, Vlahos, Ross, Jones, Jessica E, Park-Jones, Ruth A, Deliyannis, Georgia, ...
La Gruta, Nicole L., Thomas, Paul G., Webb, Andrew I., Dunstone, Michelle A., Cukalac, Tania, Doherty, Peter C., ...
TCR repertoire diversity has been convincingly shown to facilitate responsiveness of CD8+ T cell populations to mutant virus peptides, thereby safeguarding against viral escape. However, the impact...
Load Balancing for Conservative Simulation on Shared Memory Multiprocessor Systems
Boon Ping Gan, Yoke Hean Low, Sanjay Jain, Stephen J. Turner, Wentong Cai, Wen Jing Hsu, ...
Load balancing is a crucial factor in achieving good performance for parallel discrete event simulations. In this paper, we present a load balancing scheme that combines both static partitioning and...
Kedzierska, Katherine, Guillonneau, Carole, Gras, Stephanie, Hatton, Lauren A., Webby, Richard, Purcell, Anthony W., ...
Understanding T cell immunodominance hierarchies is fundamental to the development of cellular-based vaccines and immunotherapy. A combination of influenza virus infection in C57BL/6J mice and...
Guillonneau, Carole, Mintern, Justine D., Hubert, François-Xavier, Hurt, Aeron C., Besra, Gurdyal S., Porcelli, Steven, ...
Current influenza A virus vaccines do not generate significant immunity against serologically distinct influenza A virus subtypes and would thus be ineffective in the face of a pandemic caused by a...
Transience of MHC Class I-restricted antigen presentation after influenza A virus infection
Mintern, Justine D., Bedoui, Sammy, Davey, Gayle M., Moffat, Jessica M., Doherty, Peter C., Turner, Stephen J.
Antigen expressed as MHC Class I glycoprotein (pMHCI) complexes on dendritic cells is the primary driver of CD8+ T cell clonal expansion and differentiation. As we seek to define the molecular...