Yang, Tao, Martignetti, John A., Massa, Stephen M., Longo, Frank M.
Regulation of cell proliferation by protein tyrosine phosphatases (PTPs) suggests that PTPs are important tumor suppressor genes. The gene encoding the leukocyte common-antigen-related (LAR) PTP...
Neuroprotective Strategies in Alzheimer’s Disease
Longo, Frank M., Massa, Stephen M.
Summary: In addition to strategies designed to decrease amyloid beta (Aβ) levels, it is likely that successful Alzheimer’s disease (AD) therapeutic regimens will require the concomitant...
Nguyen, Trent, Hamby, Aaron, Massa, Stephen M.
In investigating the role of metal ions in the pathogenesis of Huntington's disease, we examined the effects of clioquinol, a metal-binding compound currently in clinical trials for Alzheimer's...
Neuroprotective Strategies in Alzheimer’s Disease
Longo, Frank M., Massa, Stephen M.
Summary: In addition to strategies designed to decrease amyloid beta (Aβ) levels, it is likely that successful Alzheimer’s disease (AD) therapeutic regimens will require the concomitant...
Nguyen, Trent, Hamby, Aaron, Massa, Stephen M.
In investigating the role of metal ions in the pathogenesis of Huntington's disease, we examined the effects of clioquinol, a metal-binding compound currently in clinical trials for Alzheimer's...
Yang, Tao, Knowles, Juliet K., Lu, Qun, Zhang, Hong, Arancio, Ottavio, Moore, Laura A., ...
The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75NTR ligands found to...