Reid, Robert C., Abbenante, Giovanni, Taylor, Stephen M., Fairlie, David P.
Relatively few cyclic peptides have reached the pharmaceutical marketplace during the past decade, most produced through fermentation rather than made synthetically. Generally, this class of...
Effects of a new C5a receptor antagonist on C5a- and endotoxin- induced neutropenia in the rat
Short, Anna, Wong, Allan K, Finch, Angela M, Haaima, Gerald, Shiels, Ian A, Fairlie, David P, ...
A new C5a receptor antagonist, the cyclic peptide Phe-[Orn-Pro-D-cyclohexylalanine-Trp-Arg], (F-[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin...
Response-selective C5a agonists: differential effects on neutropenia and hypotension in the rat
Short, Anna J, Paczkowski, Natalii J, Vogen, Shawn M, Sanderson, Sam D, Taylor, Stephen M
Some in vivo activities of two complement C5a agonist analogues have been evaluated by measuring changes in blood pressure and neutropenia in the rat and comparing the results with their receptor...
Pharmacological characterization of antagonists of the C5a receptor
Paczkowski, Natalii J, Finch, Angela M, Whitmore, Jacqueline B, Short, Anna J, Wong, Allan K, Monk, Peter N, ...
Potent and highly selective small molecule antagonists have recently been developed by us for C5a receptors (C5aR) on human polymorphonuclear leukocytes (PMN). In this study we compared a new cyclic...
Miric, Goran, Dallemagne, Catherine, Endre, Zoltan, Margolin, Solomon, Taylor, Stephen M, Brown, Lindsay
Fibrosis leads to chronic impairment of cardiac and renal function and thus reversal of existing fibrosis may improve function and survival. This project has determined whether pirfenidone, a new...
Strachan, Anna J, Shiels, Ian A, Reid, Robert C, Fairlie, David P, Taylor, Stephen M
Initiation of a peritoneal Arthus reaction by deposition of immune-complexes results in vascular leakage, polymorphonuclear leukocyte (PMN) infiltration, and tumour necrosis factor α (TNFα) and...
Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats
Mirkovic, Stevo, Seymour, Anne-Marie L, Fenning, Andrew, Strachan, Anna, Margolin, Solomon B, Taylor, Stephen M, ...
This study has administered pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) or amiloride to attenuate the remodelling and associated functional changes, especially an increased cardiac stiffness, in...
Arumugam, Thiruma V, Arnold, Naomi, Proctor, Lavinia M, Newman, Michelle, Reid, Robert C, Hansford, Karl A, ...
A new group IIa sPLA2 inhibitor was compared with selective inhibitors of COX-1, COX-2 and an LTC4 antagonist for effects on local and remote tissue injuries following ischaemia and reperfusion (I/R)...
Proctor, Lavinia M, Arumugam, Thiruma V, Shiels, Ian, Reid, Robert C, Fairlie, David P, Taylor, Stephen M
Complement activation is implicated in the pathogenesis of intestinal ischaemia–reperfusion injury (I/R), although the relative importance of individual complement components is unclear. A C3a...
Distinctive pharmacological profile of a nonadrenergic inhibitory system in bullfrog lung
Downes, Hall, Taylor, Stephen M.
1 Bullfrog hemilungs, pretreated with atropine, are markedly relaxed on addition of carbachol. Since the relaxant effect is inhibited by tetrodotoxin or hexamethonium, it is neurally mediated and...