Stephen Maren

Neuroscience. The threatened brain (2007)

http://deepblue.lib.umich.edu/bitstream/2027.42/56195/2/marenSCI07.pdf

Hippocampal involvement in contextual modulation of fear extinction (2007)

Peer Reviewed

Hippocampal regulation of context-dependent activity in the lateral amygdala (2007)

Extinction of fear conditioning in animals is an excellent model for the study of fear inhibition in humans. Substantial evidence has shown that extinction is a new learning process that is highly...

Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala (2007)

Pavlovian fear conditioning is a robust and enduring form of emotional learning that provides an ideal model system for studying contextual regulation of memory retrieval. After extinction the...

Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala (2007)

Pavlovian fear conditioning is a robust and enduring form of emotional learning that provides an ideal model system for studying contextual regulation of memory retrieval. After extinction the...

Hippocampal involvement in contextual modulation of fear extinction (2007)

Pavlovian fear conditioning is a robust and enduring form of emotional learning that provides an ideal model system for studying contextual regulation of memory retrieval. After extinction the...

Recent fear is resistant to extinction (2006)

Extinction of fear conditioning in animals is an excellent model for the study of fear inhibition in humans. Substantial evidence has shown that extinction is a new learning process that is highly...

Maren, Stephen, Chang, Chun-hui

In some individuals, fearful experiences (e.g., combat) yield persistent and debilitating psychological disturbances, including posttraumatic stress disorder (PTSD). Early intervention (e.g.,...

Contextual and temporal modulation of extinction: behavioral and biological mechanisms (2006)

Bouton, Mark E., Westbrook, R. Frederick, Corcoran, Kevin A., Maren, Stephen

Extinction depends, at least partly, on new learning that is specific to the context in which it is learned. Several behavioral phenomena (renewal, reinstatement, spontaneous recovery, and rapid...

Dynamic amino acid increases in the basolateral amygdala during acquisition and expression of conditioned fear (2006)

Venton, Barbara J., Robinson, Terry E., Kennedy, Robert T., Maren, Stephen

Glutamate and gamma-aminobutyric acid (GABA) release in the amygdala are thought to be crucial for the acquisition and expression of fear memories, but the time course of amino acid changes during...

Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats (2006)

Hobin, Jennifer A., Ji, Jinzhao, Maren, Stephen

Research aimed at understanding Pavlovian fear memory extinction has yielded considerable insight into the conditions under which fear memories may become inhibited. After extinction, Pavlovian fear...

Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear (2006)

Garcia, Renee, Chang, Chun-hui, Maren, Stephen

Lesion studies indicate that rats without the medial prefrontal cortex (mPFC) have difficulty recalling fear extinction acquired the previous day. Several electrophysiological studies have also...

Hitting Ras where it counts: Ras antagonism in the basolateral amygdala inhibits long-term fear memory (2006)

Merino, Stephen M., Maren, Stephen

Several studies have implicated the Ras/mitogen-activated protein kinase (MAPK) pathway in Pavlovian fear conditioning. RasGRF1 knockout mice show significant deficits in acquisition of long-term...

Allergy immunotherapy as an early intervention in patients with child-onset atopic asthma (2006)

Nagaya, Hiroshi, Maren, Stephen, Nagaya, Naomi

BACKGROUND: In patients with bronchial asthma an effective treatment is required at early stages of the disease to prevent irreversible structural changes of the airways. The objective of this study...

Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats (2006)

Hobin, Jennifer A., Ji, Jinzhao, Maren, Stephen

Research aimed at understanding Pavlovian fear memory extinction has yielded considerable insight into the conditions under which fear memories may become inhibited. After extinction, Pavlovian fear...

Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear (2006)

Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear (2006)

Lesion studies indicate that rats without the medial prefrontal cortex (mPFC) have difficulty recalling fear extinction acquired the previous day. Several electrophysiological studies have also...

Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear (2006)

Lesion studies indicate that rats without the medial prefrontal cortex (mPFC) have difficulty recalling fear extinction acquired the previous day. Several electrophysiological studies have also...

Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetamine (2005)

Lesion studies indicate that rats without the medial prefrontal cortex (mPFC) have difficulty recalling fear extinction acquired the previous day. Several electrophysiological studies have also...

Briand, Lisa A., Robinson, Terry E., Maren, Stephen

Prior exposure to drugs of abuse has been shown to occlude the structural plasticity associated with living in a complex environment. Amphetamine treatment may also occlude some cognitive advantages...

Central and basolateral amygdala neurons crash the aversive conditioning party: Theoretical comment on Rorick-Kehn and Steinmetz (2005) (2005)

Synaptic mechanisms of associative memory in the amygdala (2005)

Peer Reviewed

Hippocampal inactivation disrupts the acquisition and contextual encoding of fear extinction (2005)

Do associative learning and synaptic long-term potentiation (LTP) depend on the same cellular mechanisms? Recent work in the amygdala reveals that LTP and Pavlovian fear conditioning induce similar...

Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A., Maren, Stephen

In recent studies, inactivation of the dorsal hippocampus before the retrieval of extinguished fear memories disrupted the context-dependent expression of these memories. In the present experiments,...

Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction (2005)

Building and burying fear memories in the brain (2005)

There is a growing body of evidence that the hippocampus is critical for context-dependent memory retrieval. In the present study, we used Pavlovian fear conditioning in rats to examine the role of...

Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetamine (2005)

The world is a dangerous place. Whether this danger takes the form of an automobile careening toward you or a verbal threat from a stranger, your brain is highly adapted to perceive such threats,...

Briand, Lisa A., Robinson, Terry E., Maren, Stephen

Prior exposure to drugs of abuse has been shown to occlude the structural plasticity associated with living in a complex environment. Amphetamine treatment may also occlude some cognitive advantages...

Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction (2005)

Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetamine (2005)

There is a growing body of evidence that the hippocampus is critical for context-dependent memory retrieval. In the present study, we used Pavlovian fear conditioning in rats to examine the role of...

Briand, Lisa A., Robinson, Terry E., Maren, Stephen

Prior exposure to drugs of abuse has been shown to occlude the structural plasticity associated with living in a complex environment. Amphetamine treatment may also occlude some cognitive advantages...

Neuronal signalling of fear memory (2004)

Maren, Stephen, Quirk, Gregory J.

The learning and remembering of fearful events depends on the integrity of the amygdala, but how are fear memories represented in the activity of amygdala neurons? Here, we review recent...

Factors regulating the effects of hippocampal inactivation on renewal of conditional fear after extinction (2004)

NMDA receptors are essential for the acquisition, but not expression, of conditional fear and associative spike firing in the lateral amygdala (2004)

After extinction of fear to a Pavlovian conditional stimulus (CS), contextual stimuli come to regulate the expression of fear to that CS. There is growing evidence that the context dependence of...

Changes in anxiety-related behaviors and hypothalamic-pituitary-adrenal activity in mice lacking the 5-HT-3A receptor (2004)

We examined the contribution of N-methyl-D-aspartate (NMDA) receptors (NMDARs) to the acquisition and expression of amygdaloid plasticity and Pavlovian fear conditioning using single-unit recording...

Bhatnagar, Seema, Sun, Linda M., Raber, Jacob, Maren, Stephen, Julius, David, Dallman, Mary F.

The serotonin-3 (5-HT-3A) receptor has been localized in limbic and brainstem structures that regulate anxiety-related behavior and hypothalamic-pituitary-adrenal (HPA) activity, but its role in...

Hippocampus and Pavlovian fear conditioning in rats: muscimol infusions into the ventral, but not dorsal, hippocampus impair the acquisition of conditional freezing to an auditory conditional stimulus (2004)

Maren, Stephen, Holt, William G.

The authors compared the effects of pharmacological inactivation of the dorsal hippocampus (DH) or ventral hippocampus (VH) on Pavlovian fear conditioning in rats. Freezing behavior served as the...

Auditory-evoked spike firing in the lateral amygdala and Pavlovian fear conditioning: mnemonic code or fear bias? (2003)

Goosens, Ki A., Hobin, Jennifer A., Maren, Stephen

Amygdala neuroplasticity has emerged as a candidate substrate for Pavlovian fear memory. By this view, conditional stimulus (CS)-evoked activity represents a mnemonic code that initiates the...

Protein synthesis in the amygdala, but not the auditory thalamus, is required for consolidation of Pavlovian fear conditioning in rats (2003)

Maren, Stephen, Ferrario, Carrie R., Corcoran, Kevin A., Desmond, Timothy J., Frey, Kirk A.

The amygdala is an essential neural substrate for Pavlovian fear conditioning. Nevertheless, long-term synaptic plasticity in amygdaloid afferents, such as the auditory thalamus, may contribute to...

Context-dependent neuronal activity in the lateral amygdala represents fear memories after extinction (2003)

Hobin, Jennifer A., Goosens, Ki A., Maren, Stephen

The context in which fear memories are extinguished has important implications for treating human fear and anxiety disorders. Extinction of Pavlovian fear conditioning is context specific; after...

What the amygdala does and doesn't do in aversive learning (2003)

Pretraining NMDA receptor blockade in the basolateral complex, but not the central nucleus, of the amygdala prevents savings of conditional fear (2003)

Peer Reviewed

The amygdala, synaptic plasticity, and fear memory (2003)

The acquisition of conditional freezing is abolished by N-methyl-D-aspartate (NMDA) receptor antagonism in the basolateral complex of the amygdala (BLA) during fear conditioning, suggesting that...

What the Amygdala Does and Doesn't Do in Aversive Learning (2003)

The nature and mechanisms of synaptic plasticity in the amygdala and the relation of amygdaloid plasticity to behavior are exciting new areas of study in neuroscience. These issues were at the heart...

Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease (2002)

Corcoran, Kevin A., Lu, Ye, Turner, R. Scott, Maren, Stephen

Recent reports have raised concerns about the ability of long-term potentiation (LTP) to account for associative learning and memory. In this paper, we review the many mechanistic similarities...

Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus (2002)

Jones, Dorothy M., Esmaeil, Nadia, Maren, Stephen, Macdonald, Robert L.

Status epilepticus is usually initially treated with a benzodiazepine such as diazepam. During prolonged seizures, however, patients often lose their sensitivity to benzodiazepines, thus developing...

Long-term potentiation as a substrate for memory: evidence from studies of amygdaloid plasticity and Pavlovian fear conditioning (2002)

Overexpression of hAPPswe Impairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease (2002)

Recent reports have raised concerns about the ability of long-term potentiation (LTP) to account for associative learning and memory. In this paper, we review the many mechanistic similarities...

Corcoran, Kevin A., Lu, Ye, Turner, R. Scott, Maren, Stephen

The amygdala is essential for the development of neuronal plasticity in the medial geniculate nucleus during auditory fear conditioning in rats (2001)

Maren, Stephen, Yap, Stanley A., Goosens, Ki A.

The medial geniculate nucleus of the thalamus (MGN) and the basolateral complex of the amygdala (BLA) are critical components of the neural circuit that mediates auditory fear conditioning. Several...

Hippocampal inactivation disrupts contextual retrieval of fear memory after extinction (2001)

Estrogen modulates sexually dimorphic contextual fear conditioning and hippocampal long-term potentiation (LTP) in rats (2001)

Recent studies implicate the hippocampus in contextual memory retrieval. The present experiments explore this possibility by examining the impact of reversible inactivation of the dorsal hippocampus...

Gupta, Rishi R., Sen, Srijan, Diepenhorst, Lisa L., Rudick, Charles N., Maren, Stephen

The present study examined the role of ovarian steroids in contextual fear conditioning and hippocampal synaptic plasticity in female rats. In experiment 1, adult female rats were ovariectomized and...

Multiple roles for synaptic plasticity in Pavlovian fear conditioning (2001)

Contextual and Auditory Fear Conditioning are Mediated by the Lateral, Basal, and Central Amygdaloid Nuclei in Rats (2001)

Long-term potentiation (LTP) is a form of synaptic plasticity that has been proposed to mediate certain forms of learning and memory. In this chapter, it is argued that LTP in the hippocampus and...

The role of contextual versus discrete drug-associated cues in promoting the induction of psychomotor sensitization to intravenous amphetamine (2000)

Crombag, Hans S., Badiani, Aldo, Maren, Stephen, Robinson, Terry E.

The environmental context in which psychostimulant drugs are administered can have a large effect on both their acute psychomotor activating effects and their ability to induce the psychomotor...

Auditory fear conditioning increases CS-elicited spike firing in lateral amygdala neurons even after extensive overtraining (2000)

Is there savings for pavlovian fear conditioning after neurotoxic basolateral amygdala lesions in rats? (2000)

We examined the influence of extensive overtraining (75 trials) of auditory fear conditioning on the expression of conditional stimulus (CS)-elicited spike firing in lateral amygdala (LA) neurons....

A role for amygdaloid PKA and PKC in the acquisition of long-term conditional fear memories in rats (2000)

Considerable evidence indicates an important role for amygdaloid nuclei in both the acquisition and expression of Pavlovian fear conditioning. Recent reports from my laboratory have focused on the...

Goosens, Ki A., Holt, William, Maren, Stephen

Although there is great interest in the cellular mechanisms underlying Pavlovian conditioning, few studies have directly examined the contribution of intracellular signaling pathways in the amygdala...

Reply to vazdarjanova (2000)

The hippocampus and contextual memory retrieval in Pavlovian conditioning (2000)

http://deepblue.lib.umich.edu/bitstream/2027.42/61936/1/marenTINS00.pdf

Maren, Stephen, Holt, William

Several theories of hippocampal function have suggested a role for the hippocampus in contextual memory retrieval. However, these theories are based on studies using permanent pretraining lesions,...

Neurobiology of Pavlovian fear conditioning (2000)

Scopolamine and Pavlovian fear conditioning in rats: dose-effect analysis (1999)

Learning the relationships between aversive events and the environmental stimuli that predict such events is essential to the survival of organisms throughout the animal kingdom. Pavlovian fear...

Anagnostaras, Stephan G., Maren, Stephen, Sage, Jennifer R., Goodrich, Stacy, Fanselow, Michael S.

Muscarinic-cholinergic antagonism produces learning and memory deficits in a wide variety of hippocampal-dependent tasks. Hippocampal lesions produce both acquisition deficits and retrograde amnesia...

Neurotoxic basolateral amygdala lesions impair learning and memory but not the performance of conditional fear in rats (1999)

Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory (1999)

We examined the influence of extensive overtraining (75 trials) on the impact of neurotoxic basolateral amygdala (BLA) lesions on Pavlovian fear conditioning in rats. As we have shown previously,...

Holt, William, Maren, Stephen

Some models of hippocampal function have suggested a role of the hippocampus in contextual memory retrieval. We have examined this hypothesis by assessing the impact of reversible inactivation of the...

Long-term potentiation in the amygdala: a mechanism for emotional learning and memory (1999)

Neurotoxic or electrolytic lesions of the ventral subiculum produce deficits in the acquisition and expression of Pavlovian fear conditioning in rats (1999)

In the mammalian brain, LTP is an enduring form of synaptic plasticity that is posited to have a role in learning and memory. Compelling new evidence for this view derives from studies of LTP in the...

Temporally graded retrograde amnesia of contextual fear after hippocampal damage in rats: within-subjects examination (1999)

The effects of neurotoxic or electrolytic ventral subicular (vSUB) lesions on the acquisition and expression of Pavlovian fear conditioning in rats were examined. Conditioning consisted of the...

Anagnostaras, Stephan G., Maren, Stephen, Fanselow, Michael S.

We have shown previously that electrolytic lesions of the dorsal hippocampus (DH) produce a severe deficit in contextual fear if made 1 d, but not 28 d, after fear conditioning (). As such, the...

Effects of 7-nitroindazole, a neuronal nitric oxide synthase (nNOS) inhibitor, on locomotor activity and contextual fear conditioning in rats (1998)

Appetitive motivational states differ in their ability to augment aversive fear conditioning in rats (Rattus norvegicus) (1998)

The effect of 7-nitroindazole (7-NI), a selective neuronal nitric oxide synthase (nNOS) inhibitor, on contextual fear conditioning in rats was examined. Systemic administration of 7-NI did not affect...

Immediate-early gene expression in the amygdala following footshock stress and contextual fear conditioning (1998)

The present experiments compared the effects of 2 appetitive motivational states on the acquisition of Pavlovian fear conditioning in rats (Rattus norvegicus). In Experiment 1, rats were deprived of...

Rosen, Jeffrey B., Fanselow, Michael S., Young, Stacey L., Sitcoske, Martin, Maren, Stephen

This study investigated the increase in expression in the amygdala of 2 immediate-early genes, c-fos and NGFI-A, following contextual fear conditioning. The immediate-shock freezing deficit paradigm...

Distinct regions of the periaqueductal gray are involved in the acquisition and expression of defensive responses (1998)

De Oca, Beatrice M., DeCola, Joseph P., Maren, Stephen, Fanselow, Michael S.

In fear conditioning, a rat is placed in a distinct environment and delivered footshock. The response to the footshock itself is called an activity burst and includes running, jumping, and...

Overtraining does not mitigate contextual fear conditioning deficits produced by neurotoxic lesions of the basolateral amygdala (1998)

Testicular hormones do not regulate sexually dimorphic Pavlovian fear conditioning or perforant-path long-term potentiation in adult male rats (1998)

The influence of overtraining on the magnitude of fear-conditioning deficits produced by neurotoxic lesions of the basolateral amygdala (BLA) was examined. Either 1 d before or 1 week after the...

Anagnostaras, Stephan G., Maren, Stephen, DeCola, Joseph P., Lane, Nathan I., Gale, Greg D., Schlinger, Barney A., ...

We recently reported that Pavlovian fear conditioning and hippocampal perforant-path long-term potentiation (LTP) are sexually dimorphic in rats. Males show greater contextual fear conditioning,...

The startled seahorse: is the hippocampus necessary for contextual fear conditioning? (1998)

Maren, Stephen, Anagnostaras, Stephan G., Fanselow, Michael S.

Peer Reviewed

Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats (1997)

Maren, Stephen, Aharonov, Gal, Fanselow, Michael S.

Electrolytic lesions of the dorsal hippocampus (DH) produce deficits in both the acquisition and expression of conditional fear to contextual stimuli in rats. To assess whether damage to DH neurons...

Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice (1997)

Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...

Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...

Electrolytic lesions of the fimbria/fornix, dorsal hippocampus, or entorhinal cortex produce anterograde deficits in contextual fear conditioning in rats (1997)

N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats (1996)

Recent data indicate that dorsal hippocampal (DH) lesions disrupt Pavlovian fear conditioning to contextual cues in rats. In the present study, we examined the effects of electrolytic lesions of the...

Maren, Stephen, Aharonov, Gal, Stote, Deborah L., Fanselow, Michael S.

Three experiments examined the effects of intra-amygdaloid infusions of an N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (APV), on contextual fear conditioning in...

Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: absence of a temporal gradient (1996)

Maren, Stephen, Aharonov, Gal, Fanselow, Michael S.

The role of the basolateral amygdala (LA) in the acquisition and expression of Pavlovian fear conditioning was examined in 80 rats. Excitotoxic lesions were made in the BLA using N-methyl-D-aspartate...

Synaptic transmission and plasticity in the amygdala: an emerging physiology of fear conditioning circuits (1996)

The amygdala and fear conditioning: has the nut been cracked? (1996)

Numerous studies in both rats and humans indicate the importance of the amygdala in the acquisition and expression of learned fear. The identification of the amygdala as an essential neural substrate...

Synaptic plasticity in the basolateral amygdala induced by hippocampal formation stimulation in vivo (1995)

Peer Reviewed

Scopolamine selectively disrupts the acquisition of contextual fear conditioning in rats (1995)

Several studies suggest that axonal projections from the hippocampal formation (HF) to the basolateral amygdala (BLA) play a role in Pavlovian fear conditioning to contextual conditional stimuli. We...

Anagnostaras, Stephan G., Maren, Stephen, Fanselow, Michael S.

Muscarinic cholinergic antagonism produces learning and memory deficits in a variety of hippocampal-dependent tasks. Hippocampal lesions produce both acquisition deficits and retrograde amnesia for...

Sexually dimorphic perforant path long-term potentiation (LTP) in urethane-anesthetized rats (1995)

Properties and mechanisms of long-term synaptic plasticity in the mammalian brain: relationships to learning and memory (1995)

Sex differences in perforant path long-term potentiation (LTP) have been reported in pentobarbital-anesthetized rats. Because this effect may be due to the prominent sex difference in barbiturate...

Maren, Stephen, Baudry, Michel

Long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum are two forms of long-lasting synaptic plasticity that currently serve as our primary experimental...

Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning (1994)

Maren, Stephen, De Oca, Beatrice, Fanselow, Michael S.

Three experiments investigated sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats. Experiment 1 revealed a robust sex difference in the magnitude of...

Emergence neophobia correlates with hippocampal and cortical glutamate receptor binding in rats (1994)

Maren, Stephen, Tocco, Georges, Chavanne, Frederic, Baudry, Michel, Thompson, Richard F., Mitchell, Denis

Previous work from our laboratory indicated that emergence neophobia is highly correlated with perforant path long-term potentiation (LTP) in rats. In the present study, we examined the relationship...

Water deprivation enhances fear conditioning to contextual, but not discrete, stimuli in rats (1994)

Maren, Stephen, DeCola, Joseph P., Fanselow, Michael S.

Water-deprived and nondeprived rats were fear conditioned with a discrete tone conditional stimulus (CS) and an aversive footshock unconditional stimulus (US). Twenty-four and 48 hr following...

Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived rats (1994)

Maren, Stephen, DeCola, Joseph P., Swain, Rodney A., Fanselow, Michael S., Thompson, Richard F.

The influence of water deprivation on hippocampal long-term potentiation (LTP), theta rhythm, and contextual fear conditioning in rats was examined. In Experiment 1, hippocampal EEG activity and...

Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo (1993)

Maren, Stephen, Tocco, Georges, Standley, Steven, Baudry, Michel, Thompson, Richard F.

Several lines of evidence indicate that LTP in the hippocampus is associated with a change in the properties of postsynaptic glutamate receptors. In the present study, we used quantitative...

Postsynaptic factors in the expression of hippocampal long-term potentiation (LTP) in vivo / (1993)

Maren, Stephen.

Thesis (Ph. D.)--University of Southern California, 1993.

Individual differences in emergence neophobia predict magnitiude of perforant-path long-term potentiation (LTP) and plasma corticosterone levels in rats (1993)

Maren, Stephen, Patel, Ketan, Thompson, Richard F., Mitchell, Denis

Emergence neophobia was assessed in an emergence apparatus that provided a choice between novel and familiar alternatives. Two weeks following emergence testing the threshold to induce perforant path...

The effects of hippocampal lesions on two neotic choice tasks (1993)

Mitchell, Denis, Maren, Stephen, Hwang, Ray

We report two experiments in which rats with hippocampal lesions were tested in two neotic choice tasks that provided a clear distinction between novel and familiar alternatives. In the first...

Effects of the novel NMDA receptor antagonist, CGP 39551, on field potentials and the induction and expression of LTP in the dentate gyrus in vivo (1992)

Maren, Stephen, Baudry, Michel, Thompson, Richard F.

The effects of the novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, CGP 39551 [the carboxyethylester of CGP 37849; DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid], on...

Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus (1992)

Tocco, Georges, Maren, Stephen, Shors, Tracey J., Baudry, Michel, Thompson, Richard F.

The location and nature of the changes underlying long-term potentiation (LTP) remain controversial issues. In this study, we tested the possibility that changes in binding properties of the...

A negative correlation between the induction of long-term potentiation and activation of immediate early genes (1991)

Schreiber, Steven S., Maren, Stephen, Tocco, Georges, Shors, Tracey J., Thompson, Richard F.

In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos...

Basolateral amygdaloid multi-unit neuronal correlates of discriminative avoidance learning in rabbits (1991)

Maren, Stephen, Poremba, Amy, Gabriel, Michael

Basolateral (BL) amygdaloid multi-unit activity was recorded as male albino rabbits learned to avoid a foot-shock unconditioned stimulus (US) by stepping in an activity wheel to an acoustic (pure...

Differential effects of ketamine and MK-801 on the induction of long-term potentiation (1991)

Maren, Stephen, Baudry, Michel, Thompson, Richard F.

Ketamine and MK-801 are phencyclidine (PCP)-like noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor that produce a use-dependent blockade of the NMDA receptor-coupled channel....

Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice

Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...

Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...

Overexpression of hAPPswe Impairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease

Corcoran, Kevin A., Lu, Ye, Turner, R. Scott, Maren, Stephen

One of the hallmarks of the pathology in Alzheimer's disease is the deposition of amyloid plaques throughout the brain, especially within the hippocampus and amygdala. Transgenic mice that...

Contextual and Auditory Fear Conditioning are Mediated by the Lateral, Basal, and Central Amygdaloid Nuclei in Rats

Factors Regulating the Effects of Hippocampal Inactivation on Renewal of Conditional Fear After Extinction

A large body of literature implicates the amygdala in Pavlovian fear conditioning. In this study, we examined the contribution of individual amygdaloid nuclei to contextual and auditory fear...

Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction

After extinction of fear to a Pavlovian conditional stimulus (CS), contextual stimuli come to regulate the expression of fear to that CS. There is growing evidence that the context dependence of...

Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice

There is a growing body of evidence that the hippocampus is critical for context-dependent memory retrieval. In the present study, we used Pavlovian fear conditioning in rats to examine the role of...

Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...

Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...

Overexpression of hAPPswe Impairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease

Corcoran, Kevin A., Lu, Ye, Turner, R. Scott, Maren, Stephen

One of the hallmarks of the pathology in Alzheimer's disease is the deposition of amyloid plaques throughout the brain, especially within the hippocampus and amygdala. Transgenic mice that...

Contextual and Auditory Fear Conditioning are Mediated by the Lateral, Basal, and Central Amygdaloid Nuclei in Rats

Factors Regulating the Effects of Hippocampal Inactivation on Renewal of Conditional Fear After Extinction

A large body of literature implicates the amygdala in Pavlovian fear conditioning. In this study, we examined the contribution of individual amygdaloid nuclei to contextual and auditory fear...

Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction

After extinction of fear to a Pavlovian conditional stimulus (CS), contextual stimuli come to regulate the expression of fear to that CS. There is growing evidence that the context dependence of...

Electrolytic lesions of the medial prefrontal cortex do not interfere with long-term memory of extinction of conditioned fear

There is a growing body of evidence that the hippocampus is critical for context-dependent memory retrieval. In the present study, we used Pavlovian fear conditioning in rats to examine the role of...

Recent fear is resistant to extinction

Lesion studies indicate that rats without the medial prefrontal cortex (mPFC) have difficulty recalling fear extinction acquired the previous day. Several electrophysiological studies have also...

Maren, Stephen, Chang, Chun-hui

In some individuals, fearful experiences (e.g., combat) yield persistent and debilitating psychological disturbances, including posttraumatic stress disorder (PTSD). Early intervention (e.g.,...

Hippocampal involvement in contextual modulation of fear extinction

Hippocampal regulation of context-dependent neuronal activity in the lateral amygdala

Extinction of fear conditioning in animals is an excellent model for the study of fear inhibition in humans. Substantial evidence has shown that extinction is a new learning process that is highly...

The central nucleus of the amygdala is essential for acquiring and expressing conditional fear after overtraining

Pavlovian fear conditioning is a robust and enduring form of emotional learning that provides an ideal model system for studying contextual regulation of memory retrieval. After extinction the...

Zimmerman, Joshua M., Rabinak, Christine A., McLachlan, Ian G., Maren, Stephen

The basolateral complex of the amygdala (BLA) is critical for the acquisition and expression of Pavlovian fear conditioning in rats. Nonetheless, rats with neurotoxic BLA lesions can acquire...

PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories

Serrano, Peter, Friedman, Eugenia L, Kenney, Jana, Taubenfeld, Stephen M, Zimmerman, Joshua M, Hanna, John, ...

How long-term memories are stored is a fundamental question in neuroscience. The first molecular mechanism for long-term memory storage in the brain was recently identified as the persistent action...

Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear