Stephen P. Muench

Maternal Inheritance and Stage-Specific Variation of the Apicoplast in Toxoplasma gondii during Development in the Intermediate and Definitive Host

Ferguson, David J. P., Henriquez, Fiona L., Kirisits, Michael J., Muench, Stephen P., Prigge, Sean T., Rice, David W., ...

The structure and location of Toxoplasma gondii apicoplasts were examined in intermediate and definitive hosts and shown to vary in a stage-specific manner. Immunocytochemistry and electron...

Maternal Inheritance and Stage-Specific Variation of the Apicoplast in Toxoplasma gondii during Development in the Intermediate and Definitive Host

Ferguson, David J. P., Henriquez, Fiona L., Kirisits, Michael J., Muench, Stephen P., Prigge, Sean T., Rice, David W., ...

The structure and location of Toxoplasma gondii apicoplasts were examined in intermediate and definitive hosts and shown to vary in a stage-specific manner. Immunocytochemistry and electron...

The essential GTPase YphC displays a major domain rearrangement associated with nucleotide binding

Muench, Stephen P., Xu, Ling, Sedelnikova, Svetlana E., Rice, David W.

The structure of a Bacillus subtilis YphC/GDP complex shows that it contains two GTPase domains that pack against a central domain whose fold resembles that of an RNA binding KH-domain. Comparisons...

Cloning, purification and preliminary crystallographic analysis of the Bacillus subtilis GTPase YphC–GDP complex

Xu, Ling, Muench, Stephen P., Roujeinikova, Anna, Sedelnikova, Svetlana E., Rice, David W.

Crystals of a selenomethionine-incorporated YphC–GDP complex have been grown using the hanging-drop vapour-diffusion method and polyethylene glycol as a precipitating agent.

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase

Muench, Stephen P., Prigge, Sean T., Zhu, Liqun, Kirisits, Michael J., Roberts, Craig W., Wernimont, Sarah, ...

Crystals of T. gondii ENR in complex with NAD+ and triclosan were grown using the hanging-drop vapour-diffusion method with PEG 8000 as precipitant.

Molecular Basis for Resistance of Acanthamoeba Tubulins to All Major Classes of Antitubulin Compounds▿ †

Henriquez, Fiona L., Ingram, Paul R., Muench, Stephen P., Rice, David W., Roberts, Craig W.

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule...

Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

Muench, Stephen P., Prigge, Sean T., McLeod, Rima, Rafferty, John B., Kirisits, Michael J., Roberts, Craig W., ...

The crystal structures of T. gondii and P. falciparum ENR in complex with NAD+ and triclosan and of T. gondii ENR in an apo form have been solved to 2.6, 2.2 and 2.8 Å, respectively.