Stephen R. Thom

Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide

Thom, Stephen R., Fisher, Donald, Xu, Y. Anne, Notarfrancesco, Kathy, Ischiropoulos, Harry

Prior studies have shown that exposure to carbon monoxide (CO) will elevate the steady-state concentration of nitric oxide (⋅NO) in several cell types and body organs and that some toxic effects of...

Microbial Growth Modification by Compressed Gases and Hydrostatic Pressure

Thom, Stephen R., Marquis, Robert E.

Studies of the growth-modifying actions for Escherichia coli, Saccharomyces cerevisiae, and Tetrahymena thermophila of helium, nitrogen, argon, krypton, xenon, and nitrous oxide led to the conclusion...

Delayed neuropathology after carbon monoxide poisoning is immune-mediated

Thom, Stephen R., Bhopale, Veena M., Fisher, Donald, Zhang, Jie, Gimotty, Phyllis

The neuropathological sequelae of carbon monoxide (CO) poisoning cannot be explained by hypoxic stress alone. CO poisoning also causes adduct formation between myelin basic protein (MBP) and...

Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide

Thom, Stephen R., Fisher, Donald, Xu, Y. Anne, Notarfrancesco, Kathy, Ischiropoulos, Harry

Prior studies have shown that exposure to carbon monoxide (CO) will elevate the steady-state concentration of nitric oxide (⋅NO) in several cell types and body organs and that some toxic effects of...

Microbial Growth Modification by Compressed Gases and Hydrostatic Pressure

Thom, Stephen R., Marquis, Robert E.

Studies of the growth-modifying actions for Escherichia coli, Saccharomyces cerevisiae, and Tetrahymena thermophila of helium, nitrogen, argon, krypton, xenon, and nitrous oxide led to the conclusion...

Delayed neuropathology after carbon monoxide poisoning is immune-mediated

Thom, Stephen R., Bhopale, Veena M., Fisher, Donald, Zhang, Jie, Gimotty, Phyllis

The neuropathological sequelae of carbon monoxide (CO) poisoning cannot be explained by hypoxic stress alone. CO poisoning also causes adduct formation between myelin basic protein (MBP) and...

Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1α

Gallagher, Katherine A., Liu, Zhao-Jun, Xiao, Min, Chen, Haiying, Goldstein, Lee J., Buerk, Donald G., ...

Endothelial progenitor cells (EPCs) are essential in vasculogenesis and wound healing, but their circulating and wound level numbers are decreased in diabetes. This study aimed to determine...

Intravascular Neutrophil Activation Due to Carbon Monoxide Poisoning

Thom, Stephen R., Bhopale, Veena M., Han, Shih-Tsung, Clark, James M., Hardy, Kevin R.

Rationale: We hypothesized that platelet–neutrophil interactions occur as a result of acute carbon monoxide (CO) poisoning, and subsequent neutrophil activation triggers events that cause...

Lactate Stimulates Vasculogenic Stem Cells via the Thioredoxin System and Engages an Autocrine Activation Loop Involving Hypoxia-Inducible Factor 1▿

Milovanova, Tatyana N., Bhopale, Veena M., Sorokina, Elena M., Moore, Jonni S., Hunt, Thomas K., Hauer-Jensen, Martin, ...

The recruitment and differentiation of circulating stem/progenitor cells (SPCs) in subcutaneous Matrigel in mice was assessed. There were over one million CD34+ SPCs per Matrigel plug 18 h after...