Stephen Zicha

Atrial fibrillation-associated minK38G/S polymorphism modulates delayed rectifier current and membrane localization (2005)

Ehrlich, Joachim R., Zicha, Stephen, Coutu, Pierre, Hébert, Terence E., Nattel, Stanley

Background: Atrial fibrillation (AF) is a common acquired arrhythmia with multi-factorial pathogenesis. Recently, a single nucleotide polymorphism (SNP, A/G) at position 112 in the KCNE1 gene,...

Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model (2005)

Zicha, Stephen, Fernández-Velasco, María, Lonardo, Giuseppe, L'Heureux, Nathalie, Nattel, Stanley

Background: The hyperpolarization-activated cation current If contributes significantly to sinoatrial node pacemaker function and possibly to ectopic arrhythmogenesis. Little is known about the...

Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts

Zicha, Stephen, Xiao, Ling, Stafford, Sara, Cha, Tae Joon, Han, Wei, Varro, Andras, ...

The transient outward current (Ito), an important contributor to transmural electrophysiological heterogeneity, is significantly remodelled in congestive heart failure (CHF). The molecular bases of...

Transmural expression of transient outward potassium current subunits in normal and failing canine and human hearts

Zicha, Stephen, Xiao, Ling, Stafford, Sara, Cha, Tae Joon, Han, Wei, Varro, Andras, ...

The transient outward current (Ito), an important contributor to transmural electrophysiological heterogeneity, is significantly remodelled in congestive heart failure (CHF). The molecular bases of...