Yangbing Zhao, Maria R. Parkhurst, Zhili Zheng, Cyrille J. Cohen, John P. Riley, Luca Gattinoni, ...
Adoptive cell transfer (ACT) of tumor-reactive lymphocytes has been shown to be an effective treatment for cancer patients. Studies in murine models of ACT indicated that antitumor efficacy of...
De Vita, Vincent T., Hellman, Samuel, Rosenberg, Steven A.
Incluye bibliografía e índice
DeVita, Vincent T, Hellman, Samuel, Rosenberg, Steven A
Incluye bibliografía e índice
Kammula, Udai S., Marincola, Francesco M., Rosenberg, Steven A.
Background: Monitoring the immune response to epitope-specific vaccination in cancer patients is important for vaccine development. The traditional method, in which the in vitro sensitization of...
DeVita, Vincent T., Hellman, Samuel, Rosenberg, Steven A.
Incluye bibliografía e índice
Mulé, James J., Custer, Mary, Averbook, Bruce, Yang, James C., Weber, Jeffrey S., Goeddel, David V., ...
Overview summary Members of the chemokine superfamily mediate potent and selective chemoattraction of a variety of immune cell subsets, which is concentration dependent. This important and novel...
Tumor-infiltrating lymphocytes (TILs) have been grown from patients with metastatic melanoma and administered to the autologous patients to identify those TIL populations capable of mediating tumor...
Restifo, Nicholas P., Marincola, Francesco M., Kawakami, Yutaka, Taubenberger, Jeff, Yannelli, John R., Rosenberg, Steven A.
Background: In a subset of patients with metastatic melanoma, T lymphocytes bearing the cell-surface marker CD8 (CD8+ T cells) can cause the regression of even large tumors. These antitumor...
Rosenberg, Steven A., Yannelli, John R., Yang, James C., Topalian, Suzanne L., Schwartzentruber, Douglas J., Weber, Jeffrey S., ...
Background: Studies of human tumor-infiltrating lymphocytes (TILs) derived from patients with a variety of histologic types of cancer have demonstrated that cellular immune reactions against...
Rosenberg, Steven A., Lotze, Michael T., Yang, James C., Topalian, Suzanne L., Chang, Alfred E., Schwartzentruber, Douglas J., ...
Background: Treatment using interleukin-2 (IL-2) alone or in conjunction with lymphokine-activated killer (LAK) cells has been shown to mediate disease regression in selected patients with advanced...
Aebersold, Paul, Hyatt, Cornelia, Johnson, Susan, Hines, Ken, Korcak, Laura, Sanders, Melinda, ...
Tumor–infiltrating lymphocytes (TILs) can be grown in vitro in medium containing interleukin–2 (IL–2). In clinical trials at the Surgery Branch of the National Cancer Institute, patients with...
Weber, Jeffrey S., Rosenberg, Steven A.
Tumor-infiltrating lymphocytes (TILs) are T cells that can be grown from enzyme-digested murine or human tumors. When adoptively transferred to tumor-bearing hosts concurrent with the administration...
Griffith, Kean D., Read, Elizabeth J., Carrasquillo, Jorge A., Carter, Charles S., Yang, James C., Fisher, Beth, ...
Patients with metastatic melanoma undergoing therapy with cyclophosphamide (CPM), tumor-infiltrating lymphocytes (TIL), and interleukin-2 (IL-2) were studied for the ability of their 111In-labeled...
Hellman, Samuel, Rosenberg, Steven A.
Traducción de: Cancer principles and practice of oncology
Ettinghausen, Stephen E., Puri, Raj K., Rosenberg, Steven A.
Significant tumor regressions in mice with established carcinomas, sarcomas, and melanomas and in humans with advanced cancers have been observed following immunitherapy with lymphokine-activated...
Rosenberg, Steven A., Schwarz, Susan L., Spiess, Paul J.
Attempts have been made to design optimal strategies for the immunotherapy of established tumors. In micebearing pulmonary metastases from sarcomas, a substantial therapeutic synergy was seen when...
DeVita, Vincent T., Hellman, Samuel, Rosenberg, Steven A.
Traducción de: Aids: etiology, diagnosis, treatment and prevention
Overwijk, Willem W., Lee, David S., Surman, Deborah R., Irvine, Kari R., Touloukian, Christopher E., Chan, Chi-Chao, ...
Many human and mouse tumor antigens are normal, nonmutated tissue differentiation antigens. Consequently, immunization with these “self” antigens could induce autoimmunity. When we tried to...
Bronte, Vincenzo, Carroll, Miles W., Goletz, Theresa J., Wang, Michael, Overwijk, Willem W., Marincola, Francesco, ...
Recombinant poxviruses encoding tumor-associated antigens (TAA) are attractive as candidate cancer vaccines. Their effectiveness, however, will depend upon expression of the TAA in appropriate...
Zeng, Gang, Wang, Xiang, Robbins, Paul F., Rosenberg, Steven A., Wang, Rong-Fu
NY-ESO-1 is a tumor-specific shared antigen with distinctive immunogenicity. Both CD8+ T cells and class-switched Ab responses have been detected from patients with cancer. In this study, a CD4+ T...
Phan, Giao Q., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell...
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells
Klebanoff, Christopher A., Finkelstein, Steven E., Surman, Deborah R., Lichtman, Michael K., Gattinoni, Luca, Theoret, Marc R., ...
IL-15 and IL-2 possess similar properties, including the ability to induce T cell proliferation. However, whereas IL-2 can promote apoptosis and limit CD8+ memory T cell survival and proliferation,...
Rosenberg, Steven A., Dudley, Mark E.
Our recent clinical trials demonstrate that autologous cell transfer after lymphodepleting chemotherapy can cause the regression of large, vascularized tumors in patients with refractory metastatic...
Gattinoni, Luca, Klebanoff, Christopher A., Palmer, Douglas C., Wrzesinski, Claudia, Kerstann, Keith, Yu, Zhiya, ...
T cell differentiation is a progressive process characterized by phenotypic and functional changes. By transferring tumor-specific CD8+ T cells into tumor-bearing mice at various stages of...
Klebanoff, Christopher A., Gattinoni, Luca, Torabi-Parizi, Parizad, Kerstann, Keith, Cardones, Adela R., Finkelstein, Steven E., ...
Central memory CD8+ T cells (TCM) and effector memory CD8+ T cells (TEM) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo....
Zhou, Juhua, Shen, Xinglei, Hodes, Richard J., Rosenberg, Steven A., Robbins, Paul F.
Recent studies have indicated that adoptive immunotherapy with autologous anti-tumor tumor-infiltrating lymphocytes (TILs) following non-myeloablative chemotherapy mediates tumor regression in...
Gattinoni, Luca, Finkelstein, Steven E., Klebanoff, Christopher A., Antony, Paul A., Palmer, Douglas C., Spiess, Paul J., ...
Depletion of immune elements before adoptive cell transfer (ACT) can dramatically improve the antitumor efficacy of transferred CD8+ T cells, but the specific mechanisms that contribute to this...
Antony, Paul A., Piccirillo, Ciriaco A., Akpinarli, Akgül, Finkelstein, Steven E., Speiss, Paul J., Surman, Deborah R., ...
CD4+ T cells control the effector function, memory, and maintenance of CD8+ T cells. Paradoxically, we found that absence of CD4+ T cells enhanced adoptive immunotherapy of cancer when using CD8+ T...
Early Versus Delayed Shoulder Motion Following Axillary Dissection: A Randomized Prospective Study
Lotze, Michael T., Duncan, Mary A., Gerber, Lynn H., Woltering, Eugene A., Rosenberg, Steven A.
The role and timing of physical therapy following axillary dissection for melanoma, or in conjunction with modified radical mastectomy has not been extensively studied. A prospective randomized...
A Computer Evaluation of Equations for Predicting the Potential across Biological Membranes
The Goldman, Henderson, and Planck junction potential equations can be used to describe the potential across the resting giant squid axon. These equations are used to calculate the relative Na, K,...
Cancer immunotherapy: moving beyond current vaccines
Rosenberg, Steven A, Yang, James C, Restifo, Nicholas P
Great progress has been made in the field of tumor immunology in the past decade, but optimism about the clinical application of currently available cancer vaccine approaches is based more on...
Powell, Daniel J., Rosenberg, Steven A.
Successful immunotherapy with peptide vaccines depends on the in vivo generation of sufficient numbers of anti-tumor T cells with appropriate phenotypic and functional characteristics to mediate...
Adoptive immunotherapy for cancer: building on success
Gattinoni, Luca, Powell, Daniel J., Rosenberg, Steven A., Restifo, Nicholas P.
Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive...
Overwijk, Willem W., Lee, David S., Surman, Deborah R., Irvine, Kari R., Touloukian, Christopher E., Chan, Chi-Chao, ...
Many human and mouse tumor antigens are normal, nonmutated tissue differentiation antigens. Consequently, immunization with these “self” antigens could induce autoimmunity. When we tried to...
Bronte, Vincenzo, Carroll, Miles W., Goletz, Theresa J., Wang, Michael, Overwijk, Willem W., Marincola, Francesco, ...
Recombinant poxviruses encoding tumor-associated antigens (TAA) are attractive as candidate cancer vaccines. Their effectiveness, however, will depend upon expression of the TAA in appropriate...
Zeng, Gang, Wang, Xiang, Robbins, Paul F., Rosenberg, Steven A., Wang, Rong-Fu
NY-ESO-1 is a tumor-specific shared antigen with distinctive immunogenicity. Both CD8+ T cells and class-switched Ab responses have been detected from patients with cancer. In this study, a CD4+ T...
Phan, Giao Q., Yang, James C., Sherry, Richard M., Hwu, Patrick, Topalian, Suzanne L., Schwartzentruber, Douglas J., ...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T cells) capable of down-regulating T cell...
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells
Klebanoff, Christopher A., Finkelstein, Steven E., Surman, Deborah R., Lichtman, Michael K., Gattinoni, Luca, Theoret, Marc R., ...
IL-15 and IL-2 possess similar properties, including the ability to induce T cell proliferation. However, whereas IL-2 can promote apoptosis and limit CD8+ memory T cell survival and proliferation,...
Rosenberg, Steven A., Dudley, Mark E.
Our recent clinical trials demonstrate that autologous cell transfer after lymphodepleting chemotherapy can cause the regression of large, vascularized tumors in patients with refractory metastatic...
Gattinoni, Luca, Klebanoff, Christopher A., Palmer, Douglas C., Wrzesinski, Claudia, Kerstann, Keith, Yu, Zhiya, ...
T cell differentiation is a progressive process characterized by phenotypic and functional changes. By transferring tumor-specific CD8+ T cells into tumor-bearing mice at various stages of...
Klebanoff, Christopher A., Gattinoni, Luca, Torabi-Parizi, Parizad, Kerstann, Keith, Cardones, Adela R., Finkelstein, Steven E., ...
Central memory CD8+ T cells (TCM) and effector memory CD8+ T cells (TEM) are found in humans and mice; however, their relative contributions to host immunity have only recently been examined in vivo....
Early Versus Delayed Shoulder Motion Following Axillary Dissection: A Randomized Prospective Study
Lotze, Michael T., Duncan, Mary A., Gerber, Lynn H., Woltering, Eugene A., Rosenberg, Steven A.
The role and timing of physical therapy following axillary dissection for melanoma, or in conjunction with modified radical mastectomy has not been extensively studied. A prospective randomized...
A Computer Evaluation of Equations for Predicting the Potential across Biological Membranes
The Goldman, Henderson, and Planck junction potential equations can be used to describe the potential across the resting giant squid axon. These equations are used to calculate the relative Na, K,...
Wrzesinski, Claudia, Paulos, Chrystal M., Gattinoni, Luca, Palmer, Douglas C., Kaiser, Andrew, Yu, Zhiya, ...
Depleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD8+ T cells significantly enhances tumor treatment. In the current study, superior...
IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients
Ahmadzadeh, Mojgan, Rosenberg, Steven A.
Interleukin-2 (IL-2) is historically known as a T-cell growth factor. Accumulating evidence from knockout mice suggests that IL-2 is crucial for the homeostasis and function of CD4+CD25+ regulatory T...
Paulos, Chrystal M., Wrzesinski, Claudia, Hinrichs, Christian S., Chieppa, Marcello, Cassard, Lydie, ...
Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8+ T cells by depleting inhibitory lymphocytes and increasing homeostatic cytokine...
Paulos, Chrystal M., Wrzesinski, Claudia, Kaiser, Andrew, Hinrichs, Christian S., Chieppa, Marcello, Cassard, Lydie, ...
CTLA-4 dysregulation of self/tumor-reactive CD8+ T-cell function is CD4+ T-cell dependent
Gattinoni, Luca, Ranganathan, Anju, Surman, Deborah R., Palmer, Douglas C., Antony, Paul A., Theoret, Marc R., ...
Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) maintains peripheral tolerance by suppressing T-cell activation and proliferation but its precise role in vivo remains unclear. We sought to...
Gattinoni, Luca, Finkelstein, Steven E., Klebanoff, Christopher A., Antony, Paul A., Palmer, Douglas C., Spiess, Paul J., ...
Depletion of immune elements before adoptive cell transfer (ACT) can dramatically improve the antitumor efficacy of transferred CD8+ T cells, but the specific mechanisms that contribute to this...
Overwijk, Willem W., Theoret, Marc R., Finkelstein, Steven E., Surman, Deborah R., De Jong, Laurina A., Vyth-Dreese, Florry A., ...
Many tumor-associated antigens are derived from nonmutated “self” proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo with...
Biochemical Identification of a Mutated Human Melanoma Antigen Recognized by CD4+ T Cells
Pieper, Rembert, Christian, Robert E., Gonzales, Monica I., Nishimura, Michael I., Gupta, Gaorav, Settlage, Robert E., ...
CD4+ T cells play a critical role in generating and maintaining immune responses against pathogens and alloantigens, and evidence suggests an important role for them in antitumor immunity as well....
Wang, Rong-Fu, Wang, Xiang, Rosenberg, Steven A.
CD4+ T cells play an important role in antitumor immune responses and autoimmune and infectious diseases. Although many major histocompatibility complex (MHC) class I–restricted tumor antigens have...
Identification of Tyrosinase-related Protein 2 as a Tumor Rejection Antigen for the B16 Melanoma
Bloom, Matthew B., Perry-Lalley, Donna, Robbins, Paul F., Li, Yong, El-Gamil, Mona, Rosenberg, Steven A., ...
Recently, major advances have been made in the identification of antigens from human melanoma which are recognized by T cells. In spite of this, little is known about the optimal ways to use these...
Specht, Jennifer M., Wang, Gang, Do, My T., Lam, John S., Royal, Richard E., Reeves, Mark E., ...
Dendritic cells (DCs) are bone marrow–derived leukocytes that function as potent antigen presenting cells capable of initiating T cell–dependent responses from quiescent lymphocytes. DC pulsed...
Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes
Wang, Rong-Fu, Appella, Ettore, Kawakami, Yutaka, Kang, Xiaoqiang, Rosenberg, Steven A.
The infusion of TIL586 along with interleukin-2 into the autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor antigen recognized by...
Overwijk, Willem W., Tsung, Allan, Irvine, Kari R., Parkhurst, Maria R., Goletz, Theresa J., Tsung, Kangla, ...
Many tumor-associated antigens are nonmutated, poorly immunogenic tissue differentiation antigens. Their weak immunogenicity may be due to “self”-tolerance. To induce autoreactive T cells, we...
Rosenberg, Steven A., Einstein, Albert B.
From 61 to 92% of the total sialic acid of a variety of human lymphoid cell lines maintained in tissue culture is present on the cell surface as measured by its susceptibility to cleavage by...
Hsu, Cary, Jones, Stephanie A., Cohen, Cyrille J., Zheng, Zhili, Kerstann, Keith, Zhou, Juhua, ...
Malignancies arising from retrovirally transduced hematopoietic stem cells have been reported in animal models and human gene therapy trials. Whether mature lymphocytes are susceptible to insertional...
Palmer, Douglas C., Chan, Chi-Chao, Gattinoni, Luca, Wrzesinski, Claudia, Paulos, Chrystal M., Hinrichs, Christian S., ...
Nonmutated tissue differentiation antigens expressed by tumors are attractive targets for cancer immunotherapy, but the consequences of a highly effective antitumor immune response on self-tissue...
The Toxicity of Recombinant Human Interleukin-2 in Rats following Intravenous Infusion
Matory, Yvedt L., Chang, Alfred E., Lipford, Edward H., Braziel, Rita, Hyatt, Cornelia L., Rosenberg, Steven A.
Studies of recombinant interleukin-2 (RIL-2) administered by continuous intravenous infusion revealed hepatocellular toxicity and redistribution of lymphoid cells. This finding was different from the...
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
Hinrichs, Christian S., Spolski, Rosanne, Paulos, Chrystal M., Gattinoni, Luca, Kerstann, Keith W., Palmer, Douglas C., ...
IL-2 and IL-21 are closely related cytokines that might have arisen by gene duplication. Both cytokines promote the function of effector CD8+ T cells, but their distinct effects on antigen-driven...