Steven H. Nazarian

Comparative Genetic Analysis of Genomic DNA Sequences of Two Human Isolates of Tanapox virus (2007)

Nazarian, Steven H., Barrett, John W., Frace, A. Michael, Olsen-Rasmussen, Melissa, Khristova, Marina, Shaban, Mae, ...

Members of the genus Yatapoxvirus, which include Tanapox virus (TPV) and Yaba monkey tumor virus, infect primates including humans. Two strains of TPV isolated 50 years apart from patients infected...

Regulation of T-Cell Activation by Phosphodiesterase 4B2 Requires Its Dynamic Redistribution during Immunological Synapse Formation

Arp, Jacqueline, Kirchhof, Mark G., Baroja, Miren L., Nazarian, Steven H., Chau, Thu A., Strathdee, Craig A., ...

Stimulation of T cells through their antigen receptors (TCRs) causes a transient increase in the intracellular concentration of cyclic AMP (cAMP). However, sustained high levels of cAMP inhibit...

Myxoma Virus M11L Prevents Apoptosis through Constitutive Interaction with Bak

Wang, Gen, Barrett, John W., Nazarian, Steven H., Everett, Helen, Gao, Xiujuan, Bleackley, Chris, ...

M11L, a 166-amino-acid antiapoptotic protein of myxoma virus, was previously shown to bind to the peripheral benzodiazepine receptor by hydrophobic interactions at the outer mitochondrial membrane....

Regulation of T-Cell Activation by Phosphodiesterase 4B2 Requires Its Dynamic Redistribution during Immunological Synapse Formation

Arp, Jacqueline, Kirchhof, Mark G., Baroja, Miren L., Nazarian, Steven H., Chau, Thu A., Strathdee, Craig A., ...

Stimulation of T cells through their antigen receptors (TCRs) causes a transient increase in the intracellular concentration of cyclic AMP (cAMP). However, sustained high levels of cAMP inhibit...

Myxoma Virus M11L Prevents Apoptosis through Constitutive Interaction with Bak

Wang, Gen, Barrett, John W., Nazarian, Steven H., Everett, Helen, Gao, Xiujuan, Bleackley, Chris, ...

M11L, a 166-amino-acid antiapoptotic protein of myxoma virus, was previously shown to bind to the peripheral benzodiazepine receptor by hydrophobic interactions at the outer mitochondrial membrane....

Oncolytic Virotherapy Synergism with Signaling Inhibitors: Rapamycin Increases Myxoma Virus Tropism for Human Tumor Cells▿

Stanford, Marianne M., Barrett, John W., Nazarian, Steven H., Werden, Steven, McFadden, Grant

Myxoma virus is a rabbit-specific poxvirus pathogen that also exhibits a unique tropism for human tumor cells and is dramatically oncolytic for human cancer xenografts. Most tumor cell lines tested...

Yaba Monkey Tumor Virus Encodes a Functional Inhibitor of Interleukin-18▿

Nazarian, Steven H., Rahman, Masmudur M., Werden, Steven J., Villeneuve, Danielle, Meng, Xiangzhi, Brunetti, Craig, ...

Interleukin-18 (IL-18) is a critical proinflammatory cytokine whose extracellular bioactivity is regulated by a cellular IL-18 binding protein (IL-18BP). Many poxviruses have acquired variants of...