A Panoramic View of Yeast Noncoding RNA Processing (2007)
Wen-tao Peng, Mark D. Robinson, Sanie Mnaimneh, Nevan J. Krogan, Armaity P. Davierwala, Jörg Grigull, ...
that many currently uncharacterized yeast proteins are involved in biogenesis of noncoding RNA.
An actin-based wave generator organizes cell motility (2007)
Weiner, Orion D, Marganski, William A, Wu, Lani F, Altschuler, Steven J, Kirschner, Marc W
Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the...
An Actin-Based Wave Generator Organizes Cell Motility (2007)
Orion D. Weiner, William A. Marganski, Lani F. Wu, Steven J. Altschuler, Marc W. Kirschner
Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the...
Genomic characterization reveals a simple histone H4 acetylation code
Dion, Michael F., Altschuler, Steven J., Wu, Lani F., Rando, Oliver J.
The histone code hypothesis holds that covalent posttranslational modifications of histone tails are interpreted by the cell to yield a rich combinatorial transcriptional output. This hypothesis has...
Systems-level analyses identify extensive coupling among gene expression machines
Maciag, Karolina, Altschuler, Steven J, Slack, Michael D, Krogan, Nevan J, Emili, Andrew, Greenblatt, Jack F, ...
Here, we develop computational methods to assess and consolidate large, diverse protein interaction data sets, with the objective of identifying proteins involved in the coupling of multicomponent...
An Actin-Based Wave Generator Organizes Cell Motility
Weiner, Orion D, Marganski, William A, Wu, Lani F, Altschuler, Steven J, Kirschner, Marc W
Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the...
Characterizing heterogeneous cellular responses to perturbations
Slack, Michael D., Martinez, Elisabeth D., Wu, Lani F., Altschuler, Steven J.
Cellular populations have been widely observed to respond heterogeneously to perturbation. However, interpreting the observed heterogeneity is an extremely challenging problem because of the...