Asymmetric T lymphocyte division in the initiation of adaptive immune responses (2007)
Chang, John T., Palanivel, Vikram R., Kinjyo, Ichiko, Schambach, Felix, Intlekofer, Andrew M., Banerjee, Arnob, ...
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits...
Asymmetric T lymphocyte division in the initiation of adaptive immune responses (2007)
Chang, John T., Palanivel, Vikram R., Kinjyo, Ichiko, Schambach, Felix, Intlekofer, Andrew M., Banerjee, Arnob, ...
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits...
Asymmetric T lymphocyte division in the initiation of adaptive immune responses (2007)
Chang, John T., Palanivel, Vikram R., Kinjyo, Ichiko, Schambach, Felix, Intlekofer, Andrew M., Banerjee, Arnob, ...
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits...
Asymmetric T lymphocyte division in the initiation of adaptive immune responses (2007)
Chang, John T., Palanivel, Vikram R., Kinjyo, Ichiko, Schambach, Felix, Intlekofer, Andrew M., Banerjee, Arnob, ...
A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a dividing T lymphocyte initially responding to a microbe exhibits...
Atherly, Luana O., Lucas, Julie A., Felices, Martin, Yin, Catherine C., Reiner, Steven L., Berg, Leslie J.
The Tec family tyrosine kinases, Itk and Rlk, are expressed in thymocytes and peripheral T cells and regulate thresholds of T cell receptor signaling. Yet little is known about the specific role of...
Polarized Helper-T-Cell Responses against Leishmania major in the Absence of B Cells
Brown, Daniel R., Reiner, Steven L.
B-cell-to-T-cell signaling can shape helper T (Th) cell responses. During infection with Leishmania major, Th response is critical in determining the outcome of disease. Resistance depends on the...
Genetic Control of Experimental Lyme Arthritis in the Absence of Specific Immunity
Brown, Charles R., Reiner, Steven L.
Host genetics play an important role in determining resistance or susceptibility to experimental Lyme arthritis. While specific immunity appears to regulate disease resolution, innate immunity...
Clearance of Borrelia burgdorferi May Not Be Required for Resistance to Experimental Lyme Arthritis
Brown, Charles R., Reiner, Steven L.
Infection of inbred mouse strains with Borrelia burgdorferi results in the development of experimental Lyme arthritis. The degree of arthritic pathology has been suggested to correlate with the level...
Brown, Charles R., Reiner, Steven L.
Infection of susceptible mouse strains with Borrelia burgdorferi, the agent of Lyme disease, results in the development of arthritis. Components of the innate immune system may be important mediators...
Experimental Lyme Arthritis in the Absence of Interleukin-4 or Gamma Interferon
Brown, Charles R., Reiner, Steven L.
Genetic resistance and susceptibility to experimental Lyme arthritis have been linked with the production of interleukin-4 (IL-4) or gamma interferon (IFN-γ), respectively. To determine the absolute...
Polarized Helper-T-Cell Responses against Leishmania major in the Absence of B Cells
Brown, Daniel R., Reiner, Steven L.
B-cell-to-T-cell signaling can shape helper T (Th) cell responses. During infection with Leishmania major, Th response is critical in determining the outcome of disease. Resistance depends on the...
Genetic Control of Experimental Lyme Arthritis in the Absence of Specific Immunity
Brown, Charles R., Reiner, Steven L.
Host genetics play an important role in determining resistance or susceptibility to experimental Lyme arthritis. While specific immunity appears to regulate disease resolution, innate immunity...
Clearance of Borrelia burgdorferi May Not Be Required for Resistance to Experimental Lyme Arthritis
Brown, Charles R., Reiner, Steven L.
Infection of inbred mouse strains with Borrelia burgdorferi results in the development of experimental Lyme arthritis. The degree of arthritic pathology has been suggested to correlate with the level...
Brown, Charles R., Reiner, Steven L.
Infection of susceptible mouse strains with Borrelia burgdorferi, the agent of Lyme disease, results in the development of arthritis. Components of the innate immune system may be important mediators...
Experimental Lyme Arthritis in the Absence of Interleukin-4 or Gamma Interferon
Brown, Charles R., Reiner, Steven L.
Genetic resistance and susceptibility to experimental Lyme arthritis have been linked with the production of interleukin-4 (IL-4) or gamma interferon (IFN-γ), respectively. To determine the absolute...
Jenkinson, S. Rhiannon, Intlekofer, Andrew M., Sun, Guangping, Feigenbaum, Lionel, Reiner, Steven L., Bosselut, Rémy
Most T cells belong to either of two lineages defined by the mutually exclusive expression of CD4 and CD8 coreceptors: CD4 T cells are major histocompatibility complex (MHC) II restricted and have...
Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells
Intlekofer, Andrew M., Takemoto, Naofumi, Kao, Charlly, Banerjee, Arnob, Schambach, Felix, Northrop, John K., ...
Immunity to intracellular pathogens requires dynamic balance between terminal differentiation of short-lived, cytotoxic effector CD8+ T cells and self-renewal of central–memory CD8+ T cells. We now...
Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) Restricts Clonal Expansion of Helper T Cells
Doyle, Alden M., Mullen, Alan C., Villarino, Alejandro V., Hutchins, Anne S., High, Frances A., Lee, Hubert W., ...
Cytotoxic T lymphocyte antigen (CTLA)-4 plays an essential role in immunologic homeostasis. How this negative regulator of T cell activation executes its functions has remained controversial. We now...
T Helper Subset Differentiation in the Absence of Invariant Chain
Brown, Daniel R., Swier, Kevin, Moskowitz, Naomi H., Naujokas, Marisa F., Locksley, Richard M., Reiner, Steven L.
The outcome of murine infection with Leishmania major is regulated by major histocompatibility complex class II–restricted T helper cells. Invariant chain-deficient (Ii −/−) mice have impaired...
A Role for CD4 in Peripheral T Cell Differentiation
Brown, Daniel R., Moskowitz, Naomi H., Killeen, Nigel, Reiner, Steven L.
Naive CD4+ T helper cells (Th) differentiate into one of two well-defined cell types during immune responses. Mature Th1 and Th2 cells regulate the type of response as a consequence of the unique...
Gurunathan, Sanjay, Sacks, David L., Brown, Daniel R., Reiner, Steven L., Charest, Hughes, Glaichenhaus, Nicolas, ...
To determine whether DNA immunization could elicit protective immunity to Leishmania major in susceptible BALB/c mice, cDNA for the cloned Leishmania antigen LACK was inserted into a euykaryotic...
Khoruts, Alexander, Mondino, Anna, Pape, Kathryn A., Reiner, Steven L., Jenkins, Marc K.
The adoptive transfer of naive CD4+ T cell receptor (TCR) transgenic T cells was used to investigate the mechanisms by which the adjuvant lipopolysaccharide (LPS) enhance T cell clonal expansion in...
Wei, Jun, Duramad, Omar, Perng, Olivia A., Reiner, Steven L., Liu, Yong-Jun, Qin, F. Xiao-Feng
Recent studies have highlighted the importance of peripheral induction of Foxp3-expressing regulatory T cells (Tregs) in the dominant control of immunological tolerance. However, Foxp3+ Treg...