Steven R. Head

Analysis of differential expression of glycosyltransferases in healing corneas by glycogene microarrays (2010)

Saravanan, Chandrassegar, Cao, Zhiyi, Head, Steven R, Panjwani, Noorjahan

It is generally accepted that the glycans on the cell surface and extracellular matrix proteins play a pivotal role in the events that mediate re-epithelialization of wounds. Yet, the global...

Galectin-8 Induces Apoptosis in the CD4highCD8high Thymocyte Subpopulation (2007)

Tribulatti, María Virginia, Mucci, Juan, Cattaneo, Valentina, Agüero, Fernán, Gilmartin, Tim, Head, Steven R., ...

In the present work, we followed a microarray approach to analyze the expression of glycosylation-related genes on different cell populations obtained from mouse thymus. Among other genes,...

Analog Devices web site: http://www'analg'cm/industry/iMEMS (2006)

Elena M. Comelli, Mark Sutton-smith, Qi Yan, Margarida Amado, Maria Panico, Tim Gilmartin, ...

Differentiation and activation of lymphocytes are documented to result in changes in glycosylation associated with biologically important consequences. In this report, we have systematically examined...

A focused microarray approach to functional glycomics: transcriptional regulation of the glycome (2006)

Comelli, Elena M., Head, Steven R., Gilmartin, Tim, Whisenant, Thomas, Haslam, Stuart M., North, Simon J., ...

Glycosylation is the most common posttranslational modification of proteins, yet genes relevant to the synthesis of glycan structures and function are incompletely represented and poorly annotated on...

A Focused Microarray Approach to Functional Glycomics: Transcriptional Regulation of the Glycome (2005)

Comelli, Elena M., Head, Steven R., Gilmartin, Tim, Whisenant, Thomas, Haslam, Stuart M., North, Simon J., ...

Glycosylation is the most common post-translational modification of proteins, yet genes relevant to the synthesis of glycan structure and function are incompletely represented and poorly annotated on...

A Focused Microarray Approach to Functional Glycomics: Transcriptional Regulation of the Glycome (2005)

Comelli, Elena M., Head, Steven R., Gilmartin, Tim, Whisenant, Thomas, Haslam, Stuart M., North, Simon J., ...

Glycosylation is the most common post-translational modification of proteins, yet genes relevant to the synthesis of glycan structure and function are incompletely represented and poorly annotated on...

Defining the Pseudomonas aeruginosa SOS Response and Its Role in the Global Response to the Antibiotic Ciprofloxacin

Cirz, Ryan T., O'Neill, Bryan M., Hammond, Jennifer A., Head, Steven R., Romesberg, Floyd E.

Pseudomonas aeruginosa infections can be virtually impossible to eradicate, and the evolution of resistance during antibiotic therapy is a significant concern. In this study, we use DNA microarrays...

Evaluation of RNA-binding specificity of aminoglycosides with DNA microarrays

Liang, Fu-Sen, Greenberg, William A., Hammond, Jennifer A., Hoffmann, Julia, Head, Steven R., Wong, Chi-Huey

We have developed methods for using DNA array technology to probe the entire transcriptome to determine the RNA-binding specificity of ligands. Two methods were investigated. In the first method, the...

Macrophage-Derived Simian Immunodeficiency Virus Exhibits Enhanced Infectivity by Comparison with T-Cell-Derived Virus▿

Gaskill, Peter J., Zandonatti, Michelle, Gilmartin, Tim, Head, Steven R., Fox, Howard S.

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages...

Helicobacter pylori induces β3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl–Lewis x

Marcos, Nuno T., Magalhães, Ana, Ferreira, Bibiana, Oliveira, Maria J., Carvalho, Ana S., Mendes, Nuno, ...

Chronic Helicobacter pylori infection is recognized as a cause of gastric cancer. H. pylori adhesion to gastric cells is mediated by bacterial adhesins such as sialic acid–binding adhesin (SabA),...

Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes

Assarsson, Erika, Greenbaum, Jason A., Sundström, Magnus, Schaffer, Lana, Hammond, Jennifer A., Pasquetto, Valerie, ...

Vaccinia virus is the prototypic orthopoxvirus and was the vaccine used to eradicate smallpox, yet the expression profiles of many of its genes remain unknown. Using a genome tiling array approach,...

Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5

Xu, Cheng-Ran, Schaffer, Lana, Head, Steven R., Feeney, Ann J.

The usage of >100 functional murine Ig heavy chain VH genes, when rearranged to DHJH genes, generates a diverse antibody repertoire. The VH locus encompasses 2.5 Mb, and rearrangement of VH genes in...

Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively

Pebernard, Stephanie, Schaffer, Lana, Campbell, Daniel, Head, Steven R, Boddy, Michael N

The Smc5/6 holocomplex executes key functions in genome maintenance that include ensuring the faithful segregation of chromosomes at mitosis and facilitating critical DNA repair pathways. Smc5/6 is...