Roux, Isabelle, Hosie, Suzanne, Johnson, Stuart L., Bahloul, Amel, Cayet, Nadège, Nouaille, Sylvie, ...
The ribbon synapses of auditory inner hair cells (IHCs) undergo morphological and electrophysiological transitions during cochlear development. Here we report that myosin VI (Myo6), an actin-based...
Marcotti, Walter, Johnson, Stuart L, Kros, Corné J
From just after birth, mouse inner hair cells (IHCs) expressed a Ca2+-activated K+ current that was reduced by intracellular BAPTA at concentrations ≥ 1 mm. The block of this current by nifedipine...
Johnson, Stuart L, Marcotti, Walter, Kros, Corné J
Developmental changes in the coupling between Ca2+ entry and exocytosis were studied in mouse inner hair cells (IHCs) which, together with the afferent endings, form the primary synapse of the...
Marcotti, Walter, Johnson, Stuart L, Kros, Corné J
Ca2+-activated K+ currents were studied in inner hair cells (IHCs) of mature mice. IK,f, the large-conductance Ca2+-activated K+ current (BK) characteristic of mature IHCs, had a fast activation time...
Marcotti, Walter, Johnson, Stuart L, Kros, Corné J
Ca2+-activated K+ currents were studied in inner hair cells (IHCs) of mature mice. IK,f, the large-conductance Ca2+-activated K+ current (BK) characteristic of mature IHCs, had a fast activation time...
Marcotti, Walter, Johnson, Stuart L, Kros, Corné J
From just after birth, mouse inner hair cells (IHCs) expressed a Ca2+-activated K+ current that was reduced by intracellular BAPTA at concentrations ≥ 1 mm. The block of this current by nifedipine...
Johnson, Stuart L, Marcotti, Walter, Kros, Corné J
Developmental changes in the coupling between Ca2+ entry and exocytosis were studied in mouse inner hair cells (IHCs) which, together with the afferent endings, form the primary synapse of the...
Marcotti, Walter, Erven, Alexandra, Johnson, Stuart L, Steel, Karen P, Kros, Corné J
The deafness (dn) and Beethoven (Bth) mutant mice are models for profound congenital deafness (DFNB7/B11) and progressive hearing loss (DFNA36), respectively, caused by recessive and dominant...
Johnson, Stuart L, Adelman, John P, Marcotti, Walter
Inner hair cells (IHCs), the primary sensory receptors of the mammalian cochlea, fire spontaneous Ca2+ action potentials (APs) only before the onset of hearing. Although a role for APs in the...
Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells
Johnson, Stuart L, Marcotti, Walter
The Ca2+ current (ICa) in prehearing and adult inner hair cells (IHCs), the primary sensory receptors of the mammalian cochlea, is mainly carried by L-type (CaV1.3) Ca2+ channels. ICa in immature and...
Marcotti, Walter, Johnson, Stuart L, Holley, Matthew C, Kros, Corné J
Developmental changes in electrophysiological membrane properties of mouse cochlear inner hair cells (IHCs) were studied from just after terminal differentiation up to functional maturity. As early...
Sodium and calcium currents shape action potentials in immature mouse inner hair cells
Marcotti, Walter, Johnson, Stuart L, Rüsch, Alfons, Kros, Corné J
Before the onset of hearing at postnatal day 12, mouse inner hair cells (IHCs) produce spontaneous and evoked action potentials. These spikes are likely to induce neurotransmitter release onto...
Functional maturation of the exocytotic machinery at gerbil hair cell ribbon synapses
Johnson, Stuart L, Franz, Christoph, Knipper, Marlies, Marcotti, Walter
Auditory afferent fibre activity in mammals relies on neurotransmission at hair cell ribbon synapses. Developmental changes in the Ca2+ sensitivity of the synaptic machinery allow inner hair cells...