Subrayashastry Aravinda

Aib Residues in Peptaibiotics and Synthetic Sequences: Analysis of Nonhelical Conformations (2008)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Balaram, Padmanabhan

The \alpha-aminoisobutyric (Aib) residue has generally been considered to be a strongly helicogenic residue as evidenced by its ability to promote helical folding in synthetic and natural sequences....

Designed Peptides with Homochiral and Heterochiral Diproline Templates as Conformational Constraints (2008)

Chatterjee, Bhaswati, Saha, Indranil, Raghothama, Srinivasarao, Aravinda, Subrayashastry, Rai, Rajkishor, Shamala, Narayanaswamy, ...

Diproline segments have been advanced as templates for nucleation of folded structure in designed peptides. The conformational space available to homochiral and heterochiral diproline segments has...

Designed Peptides with Homochiral and Heterochiral Diproline Templates as Conformational Constraints (2008)

Chatterjee, Bhaswati, Saha, Indranil, Raghothama, Srinivasarao, Aravinda, Subrayashastry, Rai, Rajkishor, Shamala, Narayanaswamy, ...

Diproline segments have been advanced as templates for nucleation of folded structure in designed peptides. The conformational space available to homochiral and heterochiral diproline segments has...

Structural studies of model peptides \beta-, \gamma- containing and \delta- amino acids (2006)

Sengupta, Anindita, Aravinda, Subrayashastry, Shamala, Narayanaswamy, Raja, Muruga Poopathi K, Balaram, Padmanabhan

The crystal structures of five model peptides Piv-Pro-Gly-NHMe (1), Piv-Pro-\beta Gly-NHMe (2), Piv-Pro- \beta Gly-OMe (3), Piv-Pro- \delta Ava-OMe (4) and Boc-Pro- \gamma Abu-OH (5) are described...

Structural studies of model peptides \beta-, \gamma- containing and \delta- amino acids (2006)

Sengupta, Anindita, Aravinda, Subrayashastry, Shamala, Narayanaswamy, Raja, Muruga Poopathi K, Balaram, Padmanabhan

The crystal structures of five model peptides Piv-Pro-Gly-NHMe (1), Piv-Pro-\beta Gly-NHMe (2), Piv-Pro- \beta Gly-OMe (3), Piv-Pro- \delta Ava-OMe (4) and Boc-Pro- \gamma Abu-OH (5) are described...

Molecular Conformation and Packing of Peptide $\beta$ Hairpins in the Solid State: Structures of Two Synthetic Octapeptides Containing 1-Aminocycloalkane-1-Carboxylic Acid Residues at the $i+2$ Position of the $\beta$ Turn (2005)

Harini, Veldore Vidya, Aravinda, Subrayashastry, Rai, Rajkishor, Shamala, Narayanaswamy, Balaram, Padmanabhan

Peptide $\beta$-hairpin formation is facilitated by centrally positioned D-Pro-Xxx segments. The synthetic peptides Boc-Leu-Phe-Val-D-Pro-$Ac_6c$-Leu-Phe-Val-OMe (1) and...

Molecular Conformation and Packing of Peptide $\beta$ Hairpins in the Solid State: Structures of Two Synthetic Octapeptides Containing 1-Aminocycloalkane-1-Carboxylic Acid Residues at the $i+2$ Position of the $\beta$ Turn (2005)

Harini, Veldore Vidya, Aravinda, Subrayashastry, Rai, Rajkishor, Shamala, Narayanaswamy, Balaram, Padmanabhan

Peptide $\beta$-hairpin formation is facilitated by centrally positioned D-Pro-Xxx segments. The synthetic peptides Boc-Leu-Phe-Val-D-Pro-$Ac_6c$-Leu-Phe-Val-OMe (1) and...

Hydrogen-Bond Lengths in Polypeptide Helices: No Evidence for Short Hydrogen Bonds (2004)

Aravinda, Subrayashastry, Datta, Saumen, Shamala, Narayanaswamy, Balaram, Padmanabhan

The $3_1_0$ helix and \alpha helix are closely related secondary structures observed in polypeptides. The $3_1_0$ helix is characterized by successive $4\rightarrow1$ $(C_1_0)$ hydrogen bonds...

Structure and Assembly of Designed ‚beta-Hairpin Peptides in Crystals as Models for beta-Sheet Aggregation (2004)

Aravinda, Subrayashastry, Harini, Veldore Vidya, Shamala, Narayanaswamy, Das, Chittaranjan, Balaram, Padmanabhan

De noVo designed ‚b-hairpin peptides have generally been recalcitrant to crystallization. The crystal structures of four synthetic peptide ‚b-hairpins, Boc-Leu-Val-Val-DPro-Gly-Leu-Phe-Val-OMe...

Structure and Assembly of Designed ‚beta-Hairpin Peptides in Crystals as Models for beta-Sheet Aggregation (2004)

Aravinda, Subrayashastry, Harini, Veldore Vidya, Shamala, Narayanaswamy, Das, Chittaranjan, Balaram, Padmanabhan

De noVo designed ‚b-hairpin peptides have generally been recalcitrant to crystallization. The crystal structures of four synthetic peptide ‚b-hairpins, Boc-Leu-Val-Val-DPro-Gly-Leu-Phe-Val-OMe...

Hydrogen-Bond Lengths in Polypeptide Helices: No Evidence for Short Hydrogen Bonds (2004)

Aravinda, Subrayashastry, Datta, Saumen, Shamala, Narayanaswamy, Balaram, Padmanabhan

The $3_1_0$ helix and \alpha helix are closely related secondary structures observed in polypeptides. The $3_1_0$ helix is characterized by successive $4\rightarrow1$ $(C_1_0)$ hydrogen bonds...

Probing the Role of the C-H…O Hydrogen Bond Stabilized Polypeptide Chain Reversal at the C-terminus of Designed Peptide Helices. Structural Characterization of Three Decapeptides (2003)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Bandyopadhyay, Abhishek, Balaram, Padmanabhan

The structural characterization in crystals of three designed decapeptides containing a double D-segment at the C-terminus is described. The crystal structures of the peptides Boc-Leu-Aib-Val-Xxx-...

Probing the Role of the C-H···O Hydrogen Bond Stabilized Polypeptide Chain Reversal at the C-terminus of Designed Peptide Helices. Structural Characterization of Three Decapeptides (2003)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Bandyopadhyay, Abhishek, Balaram, Padmanabhan

The structural characterization in crystals of three designed decapeptides containing a double D-segment at the C-terminus is described. The crystal structures of the peptides...

\alpha-\gamma Hybrid Peptides that Contain the Conformationally Constrained Gabapentin Residue: Characterization of Mimetics of Chain Reversals (2003)

Aravinda, Subrayashastry, Ananda, Kuppanna, Shamala, Narayanaswamy, Balaram, Padmanabhan

The crystal structures of four dipeptides that contain the stereochemically constrained gamma-amino acid residue gabapentin (1-(aminomethyl) cyclohexaneacetic acid Gpn) are described. The molecular...

Aromatic-Aromatic Interactions in Crystal Structures of Helical Peptide Scaffolds Containing Projecting Phenylalanine Residues (2003)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Das, Chittaranjan, Sriranjini, Arumugam, Karle, Isabella L, Balaram, Padmanabhan

Aromatic-aromatic interactions between phenylalanine side chains in peptides have been probed by the structure determination in crystals of three peptides: Boc-Val-Ala-Phe-Aib-Val-Ala-Phe-Aib-OMe, I;...

\alpha-\gamma Hybrid Peptides that Contain the Conformationally Constrained Gabapentin Residue: Characterization of Mimetics of Chain Reversals (2003)

Aravinda, Subrayashastry, Ananda, Kuppanna, Shamala, Narayanaswamy, Balaram, Padmanabhan

The crystal structures of four dipeptides that contain the stereochemically constrained gamma-amino acid residue gabapentin (1-(aminomethyl) cyclohexaneacetic acid Gpn) are described. The molecular...

Aromatic-Aromatic Interactions in Crystal Structures of Helical Peptide Scaffolds Containing Projecting Phenylalanine Residues (2003)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Das, Chittaranjan, Sriranjini, Arumugam, Karle, Isabella L, Balaram, Padmanabhan

Aromatic-aromatic interactions between phenylalanine side chains in peptides have been probed by the structure determination in crystals of three peptides: Boc-Val-Ala-Phe-Aib-Val-Ala-Phe-Aib-OMe, I;...

Probing the Role of the C-H···O Hydrogen Bond Stabilized Polypeptide Chain Reversal at the C-terminus of Designed Peptide Helices. Structural Characterization of Three Decapeptides (2003)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Bandyopadhyay, Abhishek, Balaram, Padmanabhan

The structural characterization in crystals of three designed decapeptides containing a double D-segment at the C-terminus is described. The crystal structures of the peptides...

A Crystalline beta-Hairpin Peptide Nucleated by a Type I’ Aib-D-Ala beta-Turn: Evidence for Cross-Strand Aromatic Interactions (2002)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Rajkishore, Rai, Gopi, Hosahudya N, Balaram, Padmanabhan

Recent progress in the design of beta-hairpin peptides[1] and beta-sheet models has been based on the ability to nucleate reverse turns of the appropriate stereochemistry. D-Pro-Gly[2] and to a...

A right handed peptide helix containing a central double D-amino acid segment (2002)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Desiraju, Shrilakshmi, Balaram, Padmanabhan

The crystal structure of the 13 residue peptide Boc-Leu-Aib-Val-Ala-Leu-Aib-Val-DAla-DLeu-Aib-Leu-Aib-Val-OMe reveals a continuous helical conformation providing an unambiguous characterization of...

A Crystalline beta-Hairpin Peptide Nucleated by a Type I’ Aib-D-Ala beta-Turn: Evidence for Cross-Strand Aromatic Interactions (2002)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Rajkishore, Rai, Gopi, Hosahudya N, Balaram, Padmanabhan

Recent progress in the design of beta-hairpin peptides[1] and beta-sheet models has been based on the ability to nucleate reverse turns of the appropriate stereochemistry. D-Pro-Gly[2] and to a...

A right handed peptide helix containing a central double D-amino acid segment (2002)

Aravinda, Subrayashastry, Shamala, Narayanaswamy, Desiraju, Shrilakshmi, Balaram, Padmanabhan

The crystal structure of the 13 residue peptide Boc-Leu-Aib-Val-Ala-Leu-Aib-Val-DAla-DLeu-Aib-Leu-Aib-Val-OMe reveals a continuous helical conformation providing an unambiguous characterization of...