Sudagar S. Gurcha

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Kremer, Laurent, Gurcha, Sudagar S, Bifani, Pablo, Hitchen, Paul G, Baulard, Alain, Morris, Howard R, ...

Phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM) and lipoarabinomannan (LAM) are an important class of bacterial factors termed modulins that are found in tuberculosis and leprosy....

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

Gurcha, Sudagar S, Baulard, Alain R, Kremer, Laurent, Locht, Camille, Moody, D Branch, Muhlecker, Walter, ...

Dolichol monophosphomannose (DPM) is an ever-present donor of mannose (Man) in various eukaryotic glycosylation processes. Intriguingly, the related polyprenol monophosphomannose (PPM) is involved in...

Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.

Kremer, Laurent, Gurcha, Sudagar S, Bifani, Pablo, Hitchen, Paul G, Baulard, Alain, Morris, Howard R, ...

Phosphatidyl-myo-inositol mannosides (PIMs), lipomannan (LM) and lipoarabinomannan (LAM) are an important class of bacterial factors termed modulins that are found in tuberculosis and leprosy....

Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.

Gurcha, Sudagar S, Baulard, Alain R, Kremer, Laurent, Locht, Camille, Moody, D Branch, Muhlecker, Walter, ...

Dolichol monophosphomannose (DPM) is an ever-present donor of mannose (Man) in various eukaryotic glycosylation processes. Intriguingly, the related polyprenol monophosphomannose (PPM) is involved in...

Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice

Bhatt, Apoorva, Fujiwara, Nagatoshi, Bhatt, Kiranmai, Gurcha, Sudagar S., Kremer, Laurent, Chen, Bing, ...

Mycobacterium tuberculosis, the causative agent of tuberculosis, has two distinguishing characteristics: its ability to stain acid-fast and its ability to cause long-term latent infections in humans....

Mycolic Acid Modification by the mmaA4 Gene of M. tuberculosis Modulates IL-12 Production

Dao, Dee N., Sweeney, Kari, Hsu, Tsungda, Gurcha, Sudagar S., Nascimento, Ivan P., Roshevsky, Dan, ...

Mycobacterium tuberculosis has evolved many strategies to evade elimination by the host immune system, including the selective repression of macrophage IL-12p40 production. To identify the M....

Structural characterization and functional properties of a novel lipomannan variant isolated from a Corynebacterium glutamicum pimB′ mutant

Mishra, Arun K., Klein, Christina, Gurcha, Sudagar S., Alderwick, Luke J., Babu, Ponnusamy, Hitchen, Paul G., ...

The genus Corynebacterium is part of the phylogenetic group nocardioform actinomycetes, which also includes the genus Mycobacterium. Members of this phylogenetic group have a characteristic cell...

A Mycobacterium tuberculosis Mutant Lacking the groEL Homologue cpn60.1 Is Viable but Fails To Induce an Inflammatory Response in Animal Models of Infection▿

Hu, Yanmin, Henderson, Brian, Lund, Peter A., Tormay, Peter, Ahmed, M. Tabish, Gurcha, Sudagar S., ...

The causative agent of tuberculosis, Mycobacterium tuberculosis, has two chaperonin (Cpn60) proteins and one cochaperonin (Cpn10) protein. We show here that cpn60.2 and cpn10, but not cpn60.1, are...