Nitric Oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors. (2006)
Anning, Peter Brian, Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., ...
The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by...
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling (2000)
Brisken, Cathrin, Heineman, Anna, Chavarria, Tony, Elenbaas, Brian, Tan, Jian, Dey, Sudhansu K., ...
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
Paria, Bibhash C., Ma, Wen-ge, Tan, Jian, Raja, Shefali, Das, Sonjoy K., Dey, Sudhansu K., ...
The implantation of a blastocyst into a receptive uterus is associated with a series of events, namely the attachment reaction followed by decidualization of the stroma. Previous studies established...
Reese, Jeff, Paria, Bibhash C., Brown, Naoko, Zhao, Xuemei, Morrow, Jason D., Dey, Sudhansu K.
Cyclooxygenase (COX)-derived prostaglandins (PGs) regulate numerous maternal–fetal interactions during pregnancy. PGs stimulate uterine contractions and prepare the cervix for parturition, whereas...
Gupta, Rajnish A., Tan, Jian, Krause, Wade F., Geraci, Mark W., Willson, Timothy M., Dey, Sudhansu K., ...
There is evidence from both genetic and pharmacologic studies to suggest that the cyclooxygenase-2 (COX-2) enzyme plays a causal role in the development of colorectal cancer. However, little is known...
Ma, Wen-ge, Song, Haengseok, Das, Sanjoy K., Paria, Bibhash C., Dey, Sudhansu K.
Many underlying causes of human infertility have been overcome by using in vitro fertilization (IVF) and embryo transfer (ET) techniques. Nevertheless, implantation rates in IVF programs remain low...
Wang, Haibin, Matsumoto, Hiromichi, Guo, Yong, Paria, Bibhash C., Roberts, Richard L., Dey, Sudhansu K.
Mammalian fertility absolutely depends on synchronized development of the blastocyst to the stage when it is competent to implant, and the uterus to the stage when it is receptive to implantation....
Host cyclooxygenase-2 modulates carcinoma growth
Williams, Christopher S., Tsujii, Masahiko, Reese, Jeff, Dey, Sudhansu K., DuBois, Raymond N.
Cyclooxygenase-2 (COX-2; Ptgs2) acts as a tumor promoter in rodent models for colorectal cancer, but its precise role in carcinogenesis remains unclear. We evaluated the contribution of host-derived...
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
Brisken, Cathrin, Heineman, Anna, Chavarria, Tony, Elenbaas, Brian, Tan, Jian, Dey, Sudhansu K., ...
Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome...
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization....
Hamatani, Toshio, Daikoku, Takiko, Wang, Haibin, Matsumoto, Hiromichi, Carter, Mark G., Ko, Minoru S. H., ...
Delayed implantation (embryonic diapause) occurs when the embryo at the blastocyst stage achieves a state of suspended animation. During this period, blastocyst growth is very slow, with minimal or...
Lee, Daekee, Pearsall, R. Scott, Das, Sanjoy, Dey, Sudhansu K., Godfrey, Virginia L., Threadgill, David W.
Epiregulin, an epidermal growth factor family member, acts as a local signal mediator and shows dual biological activity, stimulating the proliferation of fibroblasts, hepatocytes, smooth muscle...
Wang, Haibin, Tranguch, Susanne, Xie, Huirong, Hanley, Gregory, Das, Sanjoy K., Dey, Sudhansu K.
Although ovarian estrogen, estradiol-17β, is a key modulator of normal reproductive functions, natural and synthetic compounds with estrogen-like activities can further influence reproductive...
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Tranguch, Susanne, Cheung-Flynn, Joyce, Daikoku, Takiko, Prapapanich, Viravan, Cox, Marc B., Xie, Huirong, ...
Embryo implantation in the uterus is a critical step in mammalian reproduction, requiring preparation of the uterus receptive to blastocyst implantation. Uterine receptivity, also known as the window...
Fatty acid amide hydrolase deficiency limits early pregnancy events
Wang, Haibin, Xie, Huirong, Guo, Yong, Zhang, Hao, Takahashi, Toshifumi, Kingsley, Philip J., ...
Synchronized preimplantation embryo development and passage through the oviduct into the uterus are prerequisites for implantation, dysregulation of which often leads to pregnancy failure in women....
Tong, Beverly J, Tan, Jian, Tajeda, Lovella, Das, Sanjoy K, Chapman, Julia A, DuBoist, Raymond N, ...
Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG)...
Paria, Bibhash C., Ma, Wen-ge, Tan, Jian, Raja, Shefali, Das, Sonjoy K., Dey, Sudhansu K., ...
The implantation of a blastocyst into a receptive uterus is associated with a series of events, namely the attachment reaction followed by decidualization of the stroma. Previous studies established...
Reese, Jeff, Paria, Bibhash C., Brown, Naoko, Zhao, Xuemei, Morrow, Jason D., Dey, Sudhansu K.
Cyclooxygenase (COX)-derived prostaglandins (PGs) regulate numerous maternal–fetal interactions during pregnancy. PGs stimulate uterine contractions and prepare the cervix for parturition, whereas...
Gupta, Rajnish A., Tan, Jian, Krause, Wade F., Geraci, Mark W., Willson, Timothy M., Dey, Sudhansu K., ...
There is evidence from both genetic and pharmacologic studies to suggest that the cyclooxygenase-2 (COX-2) enzyme plays a causal role in the development of colorectal cancer. However, little is known...
Ma, Wen-ge, Song, Haengseok, Das, Sanjoy K., Paria, Bibhash C., Dey, Sudhansu K.
Many underlying causes of human infertility have been overcome by using in vitro fertilization (IVF) and embryo transfer (ET) techniques. Nevertheless, implantation rates in IVF programs remain low...
Wang, Haibin, Matsumoto, Hiromichi, Guo, Yong, Paria, Bibhash C., Roberts, Richard L., Dey, Sudhansu K.
Mammalian fertility absolutely depends on synchronized development of the blastocyst to the stage when it is competent to implant, and the uterus to the stage when it is receptive to implantation....
Host cyclooxygenase-2 modulates carcinoma growth
Williams, Christopher S., Tsujii, Masahiko, Reese, Jeff, Dey, Sudhansu K., DuBois, Raymond N.
Cyclooxygenase-2 (COX-2; Ptgs2) acts as a tumor promoter in rodent models for colorectal cancer, but its precise role in carcinogenesis remains unclear. We evaluated the contribution of host-derived...
Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
Brisken, Cathrin, Heineman, Anna, Chavarria, Tony, Elenbaas, Brian, Tan, Jian, Dey, Sudhansu K., ...
Female reproductive hormones control mammary gland morphogenesis. In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome...
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization....
Hamatani, Toshio, Daikoku, Takiko, Wang, Haibin, Matsumoto, Hiromichi, Carter, Mark G., Ko, Minoru S. H., ...
Delayed implantation (embryonic diapause) occurs when the embryo at the blastocyst stage achieves a state of suspended animation. During this period, blastocyst growth is very slow, with minimal or...
Lee, Daekee, Pearsall, R. Scott, Das, Sanjoy, Dey, Sudhansu K., Godfrey, Virginia L., Threadgill, David W.
Epiregulin, an epidermal growth factor family member, acts as a local signal mediator and shows dual biological activity, stimulating the proliferation of fibroblasts, hepatocytes, smooth muscle...
Wang, Haibin, Tranguch, Susanne, Xie, Huirong, Hanley, Gregory, Das, Sanjoy K., Dey, Sudhansu K.
Although ovarian estrogen, estradiol-17β, is a key modulator of normal reproductive functions, natural and synthetic compounds with estrogen-like activities can further influence reproductive...
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation
Tranguch, Susanne, Cheung-Flynn, Joyce, Daikoku, Takiko, Prapapanich, Viravan, Cox, Marc B., Xie, Huirong, ...
Embryo implantation in the uterus is a critical step in mammalian reproduction, requiring preparation of the uterus receptive to blastocyst implantation. Uterine receptivity, also known as the window...
Tong, Beverly J, Tan, Jian, Tajeda, Lovella, Das, Sanjoy K, Chapman, Julia A, DuBoist, Raymond N, ...
Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) significantly reduce the risk and mortality from colorectal cancer, in part by inhibiting prostaglandin (PG)...
Fatty acid amide hydrolase deficiency limits early pregnancy events
Wang, Haibin, Xie, Huirong, Guo, Yong, Zhang, Hao, Takahashi, Toshifumi, Kingsley, Philip J., ...
Synchronized preimplantation embryo development and passage through the oviduct into the uterus are prerequisites for implantation, dysregulation of which often leads to pregnancy failure in women....
Wang, Dingzhi, Wang, Haibin, Guo, Yong, Ning, Wei, Katkuri, Sharada, Wahli, Walter, ...
Peroxisome proliferator-activated receptor (PPAR) δ is a member of the nuclear hormone receptor superfamily. PPARδ may ameliorate metabolic diseases such as obesity and diabetes. However, PPARδ's...
Tranguch, Susanne, Wang, Haibin, Daikoku, Takiko, Xie, Huirong, Smith, David F., Dey, Sudhansu K.
Immunophilin FKBP52 serves as a cochaperone to govern normal progesterone (P4) receptor (PR) function. Using Fkbp52–/– mice, we show intriguing aspects of uterine P4/PR signaling during...
Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors
Anning, Peter B., Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., ...
The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by...
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer
Wang, Dingzhi, Wang, Haibin, Brown, Joanne, Daikoku, Takiko, Ning, Wei, Shi, Qiong, ...
Chronic inflammation is a well-known risk factor for cancer. Proinflammatory mediators such as prostaglandin E2 (PGE2) promote colorectal tumor growth by stimulating angiogenesis, cell invasion, and...
COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARδ activation
Ghosh, Mallika, Wang, Haibin, Ai, Youxi, Romeo, Elisa, Luyendyk, James P., Peters, Jeffrey M., ...
Although cyclooxygenase (COX)-2 inhibitors (coxibs) are effective in controlling inflammation, pain, and tumorigenesis, their use is limited by the recent revelation of increased adverse...
MicroRNA regulation of cyclooxygenase-2 during embryo implantation
Chakrabarty, Anindita, Tranguch, Susanne, Daikoku, Takiko, Jensen, Kevin, Furneaux, Henry, Dey, Sudhansu K.
The implantation process is complex, requiring reciprocal interactions between implantation-competent blastocysts and the receptive uterus. Because microRNAs (miRNAs) have major roles in regulating...
Maternal heparin-binding-EGF deficiency limits pregnancy success in mice
Xie, Huirong, Wang, Haibin, Tranguch, Susanne, Iwamoto, Ryo, Mekada, Eisuke, DeMayo, Francesco J., ...
An intimate discourse between the blastocyst and uterus is essential for successful implantation. However, the molecular basis of this interaction is not clearly understood. Exploiting genomic Hbegf...
Deficiency of Immunophilin FKBP52 Promotes Endometriosis
Hirota, Yasushi, Tranguch, Susanne, Daikoku, Takiko, Hasegawa, Akiko, Osuga, Yutaka, Taketani, Yuji, ...
Endometriosis is a common gynecological disease that affects approximately 10% of women of childbearing age. It is characterized by endometrial growth outside the uterus and often results in inflamed...