Suparna Mazumder

Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vpu Transmembrane Domain That Promotes the Enhanced Release of Virus-Like Particles from the Plasma Membrane of Mammalian Cells

Paul, Mousumi, Mazumder, Suparna, Raja, Nicholas, Jabbar, M. Abdul

Human immunodeficiency virus type 1 Vpu is a multifunctional phosphoprotein composed of the N-terminal transmembrane (VpuTM) and C-terminal cytoplasmic domains. Each of these domains regulates a...

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...

Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells

Mazumder, Suparna, Gong, Bendi, Almasan, Alexandru

Cyclin E is essential for progression through the G1 phase of the cell cycle and initiation of DNA replication by interacting with, and activating its catalytic partner, the cyclin-dependent kinase 2...

Genotoxic Stress Induces Expression of E2F4, Leading to Its Association with p130 in Prostate Carcinoma Cells

DuPree, Erica L., Mazumder, Suparna, Almasan, Alexandru

The retinoblastoma (pRb), p107, and p130 pocket proteins bind to the E2F transcription factors to control gene expression. E2F4 protein levels increased and accumulated in the nuclei of prostate...

Mutational Analysis of the Human Immunodeficiency Virus Type 1 Vpu Transmembrane Domain That Promotes the Enhanced Release of Virus-Like Particles from the Plasma Membrane of Mammalian Cells

Paul, Mousumi, Mazumder, Suparna, Raja, Nicholas, Jabbar, M. Abdul

Human immunodeficiency virus type 1 Vpu is a multifunctional phosphoprotein composed of the N-terminal transmembrane (VpuTM) and C-terminal cytoplasmic domains. Each of these domains regulates a...

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...

Interaction of a Cyclin E Fragment with Ku70 Regulates Bax-Mediated Apoptosis▿ †

Mazumder, Suparna, Plesca, Dragos, Kinter, Michael, Almasan, Alexandru

The cyclin E/Cdk2 complex plays an essential role in the G1/S cell cycle transition and DNA replication. Earlier we showed that in hematopoietic tumor cells, caspase-mediated cleavage of cyclin E...

A C-terminal Fragment of Cyclin E, Generated by Caspase-mediated Cleavage, Is Degraded in the Absence of a Recognizable Phosphodegron*

Plesca, Dragos, Mazumder, Suparna, Gama, Vivian, Matsuyama, Shigemi, Almasan, Alexandru

We have previously shown that caspase-mediated cleavage of Cyclin E generates p18-Cyclin E in hematopoietic tumor cells. Its expression can induce apoptosis or sensitize to apoptotic stimuli in many...