Cooperative Oncogenesis and Polyploidization in Human Cancers: a Dissertation (2007)
A common phenotype observed in most cancers is chromosomal instability. This includes both structural and numerical chromosomal aberrations, which can promote carcinogenesis. The fusion gene...
Liu, Yingwang, Heilman, Susan Ann, Illanes, Diego, Sluder, Greenfield, Chen, Jason J.
Polyploidy is often an early event during cervical carcinogenesis, and it predisposes cells to aneuploidy, which is thought to play a causal role in tumorigenesis. Cervical and anogenital cancers are...
Liu, Yingwang, Heilman, Susan Ann, Illanes, Diego, Sluder, Greenfield, Chen, Jason J.
Polyploidy is often an early event during cervical carcinogenesis, and it predisposes cells to aneuploidy, which is thought to play a causal role in tumorigenesis. Cervical and anogenital cancers are...
Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice (2006)
Heilman, Susan Ann, Kuo, Ya-Huei, Goudswaard, Chantal S., Valk, Peter J., Castilla, Lucio H.
The gene encoding for core-binding factor beta (CBFbeta) is altered in acute myeloid leukemia samples with an inversion in chromosome 16, expressing the fusion protein CBFbeta-SMMHC. Previous studies...
Kuo, Ya-Huei, Landrette, Sean F., Heilman, Susan Ann, Perrat, Paola N., Garrett, Lisa, Liu, Pu P., ...
The acute myeloid leukemia (AML)-associated CBF beta-SMMHC fusion protein impairs hematopoietic differentiation and predisposes to leukemic transformation. The mechanism of leukemia progression,...
Castilla, Lucio H., Perrat, Paola N., Martinez, Natalia J., Landrette, Sean F., Keys, R., Oikemus, Sarah R., ...
Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not...