Zoller, Thomas, Fèvre, Eric M, Welburn, Susan C, Odiit, Martin, Coleman, Paul G
Abstract Background Sleeping sickness (HAT) caused by T.b. rhodesiense is a major veterinary and human public health problem in Uganda. Previous studies have investigated spatial risk factors for...
Fèvre, Eric M, Odiit, Martin, Coleman, Paul G, Woolhouse, Mark EJ, Welburn, Susan C
Abstract Background Zoonotic sleeping sickness, or HAT (Human African Trypanosomiasis), caused by infection with Trypanosoma brucei rhodesiense , is an under-reported and neglected tropical disease....
MacLeod, Ewan T, Maudlin, Ian, Welburn, Susan C
Abstract Cyclic nucleotide signalling through cyclic adenosine monophosphate (cAMP) is thought to play an important role in the transformation of the long slender (dividing) form to the short-stumpy...
Hutchinson, O Clyde, Picozzi, Kim, Jones, Nicola G, Mott, Helen, Sharma, Reuben, Welburn, Susan C, ...
Abstract Background In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic...
Susan C Welburn, Simon Lillico, Noel B Murphy
Trypanosoma brucei rhodesiense can be induced to undergo apoptosis after stimulation with Con A. As cell death in these parasites is associated with de novogene expression we have applied a...
Welburn,Susan C, Lillico,Simon, Murphy,Noel B
Trypanosoma brucei rhodesiense can be induced to undergo apoptosis after stimulation with Con A. As cell death in these parasites is associated with de novo gene expression we have applied a...
MacLeod, Annette, Tweedie, Alison, Welburn, Susan C., Maudlin, Ian, Turner, C. Michael R., Tait, Andy
The African trypanosome, Trypanosoma brucei, has been shown to undergo genetic exchange in the laboratory, but controversy exists as to the role of genetic exchange in natural populations. Much of...
The insect endosymbiont Sodalis glossinidius utilizes a type III secretion system for cell invasion
Dale, Colin, Young, Simon A., Haydon, Daniel T., Welburn, Susan C.
Sodalis glossinidius is a maternally transmitted secondary endosymbiont residing intracellularly in tissues of the tsetse flies, Glossina spp. In this study, we have used Tn5 mutagenesis and a...
Sleeping sickness in Uganda: a thin line between two fatal diseases
Picozzi, Kim, Fèvre, Eric M, Odiit, Martin, Carrington, Mark, Eisler, Mark C, Maudlin, Ian, ...
Objective To determine, through the use of molecular diagnostic tools, whether the two species of parasite that cause human African trypanosomiasis have become sympatric.
Hutchinson, O Clyde, Picozzi, Kim, Jones, Nicola G, Mott, Helen, Sharma, Reuben, Welburn, Susan C, ...
Effects of cyclic nucleotides on midgut infections and maturation of T. b. brucei in G. m. morsitans
MacLeod, Ewan T, Maudlin, Ian, Welburn, Susan C
Cyclic nucleotide signalling through cyclic adenosine monophosphate (cAMP) is thought to play an important role in the transformation of the long slender (dividing) form to the short-stumpy...
Estimating the burden of rhodesiense sleeping sickness during an outbreak in Serere, eastern Uganda
Fèvre, Eric M, Odiit, Martin, Coleman, Paul G, Woolhouse, Mark EJ, Welburn, Susan C