Analysis of one million base pairs of Neanderthal DNA (2006)
Green, Richard E., Krause, Johannes, Ptak, Susan E., Briggs, Adrian W., Ronan, Michael T., Simons, Jan F., ...
Fine-scale recombination patterns differ between chimpanzees and humans (2005)
Ptak, Susan E., Hinds, David A., Koehler, Kathrin, Nickel, Birgit, Patil, Nila, Ballinger, Dennis G., ...
Why do human diversity levels vary at a megabase scale? (2005)
Hellmann, Ines, Prüfer, Kai, Ji, H. K., Zody, M. C., Pääbo, Svante, Ptak, Susan E.
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees (2004)
Susan E. Ptak, Amy D. Roeder, Matthew Stephens, Yoav Gilad, Svante Pääbo, Molly Przeworski
The human TAP2 recombination hotspot is absent from the homologous region in western chimpanzees, with important implications for association studies, the HapMap project and understanding fine-scale...
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees (2004)
Susan E. Ptak, Amy D. Roeder, Matthew Stephens, Yoav Gilad, Svante Pääbo, Molly Przeworski
Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is concentrated in “hotspots” of 1–2 kb....
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees (2004)
Ptak, Susan E., Roeder, Amy D., Stephens, Matthew, Gilad, Yoav, Pääbo, Svante, Przeworski, Molly
Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is concentrated in “hotspots” of 1–2 kb....
On the evolution of polygyny: a theoretical examination of the polygyny threshold model (2003)
Ptak, Susan E., Lachmann, Michael
The polygyny threshold model states that if costs incurred are less than the benefits gained from mating polygynously in terms of breeding-situation quality, then polygyny is favored and could...
How intron splicing affects the deletion and insertion profile in Drosophila melanogaster (2002)
Studies of "dead-on-arrival" transposable elements in Drosophila melanogaster found that deletions outnumber insertions similar to8:1 with a median size for deletions of similar to10 bp. These...
Evidence for population growth in humans is confounded by fine- scale population structure (2002)
Ptak, Susan E., Przeworski, Molly
Although many studies have reported human polymorphism data, there has been no analysis of the effect of sampling design on the patterns of variability recovered. Here, we consider which factors...
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees
Ptak, Susan E, Roeder, Amy D, Stephens, Matthew, Gilad, Yoav, Pääbo, Svante, Przeworski, Molly
Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is concentrated in “hotspots” of 1–2 kb....
Why do human diversity levels vary at a megabase scale?
Hellmann, Ines, Prüfer, Kay, Ji, Hongkai, Zody, Michael C., Pääbo, Svante, Ptak, Susan E.
Levels of diversity vary across the human genome. This variation is caused by two forces: differences in mutation rates and the differential impact of natural selection. Pertinent to the question of...
How intron splicing affects the deletion and insertion profile in Drosophila melanogaster.
Ptak, Susan E, Petrov, Dmitri A
Studies of "dead-on-arrival" transposable elements in Drosophila melanogaster found that deletions outnumber insertions approximately 8:1 with a median size for deletions of approximately 10 bp....
Insights into recombination from patterns of linkage disequilibrium in humans.
Ptak, Susan E, Voelpel, Kristian, Przeworski, Molly
An ability to predict levels of linkage disequilibrium (LD) between linked markers would facilitate the design of association studies and help to distinguish between evolutionary models....
Absence of the TAP2 Human Recombination Hotspot in Chimpanzees
Ptak, Susan E, Roeder, Amy D, Stephens, Matthew, Gilad, Yoav, Pääbo, Svante, Przeworski, Molly
Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is concentrated in “hotspots” of 1–2 kb....
A Neutral Explanation for the Correlation of Diversity with Recombination Rates in Humans
Hellmann, Ines, Ebersberger, Ingo, Ptak, Susan E., Pääbo, Svante, Przeworski, Molly
One of the most striking findings to emerge from the study of genomic patterns of variation is that regions with lower recombination rates tend to have lower levels of intraspecific diversity but not...
Why do human diversity levels vary at a megabase scale?
Hellmann, Ines, Prüfer, Kay, Ji, Hongkai, Zody, Michael C., Pääbo, Svante, Ptak, Susan E.
Levels of diversity vary across the human genome. This variation is caused by two forces: differences in mutation rates and the differential impact of natural selection. Pertinent to the question of...
How intron splicing affects the deletion and insertion profile in Drosophila melanogaster.
Ptak, Susan E, Petrov, Dmitri A
Studies of "dead-on-arrival" transposable elements in Drosophila melanogaster found that deletions outnumber insertions approximately 8:1 with a median size for deletions of approximately 10 bp....
Insights into recombination from patterns of linkage disequilibrium in humans.
Ptak, Susan E, Voelpel, Kristian, Przeworski, Molly
An ability to predict levels of linkage disequilibrium (LD) between linked markers would facilitate the design of association studies and help to distinguish between evolutionary models....
Clark, Vanessa J., Ptak, Susan E., Tiemann, Irene, Qian, Yudong, Coop, Graham, Stone, Anne C., ...
A previous polymorphism survey of the type 2 diabetes gene CAPN10 identified a segment showing an excess of polymorphism levels in all population samples, coinciding with localized breakdown of...