Susan E. Quaggin

RAS BLOCKADE DECREASES BLOOD PRESSURE AND PROTEINURIA IN TRANSGENIC MICE (2005)

Renal Disease, Vera Eremina, Karen Sison, George Fantus, Napoleone Ferrara, ...

The glomerular filtration barrier separates the blood from the urinary space and is made up of podocytes, endothelial cells and an intervening glomerular basement membrane. Vascular endothelial...

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction (2005)

Belteki, Gusztav, Haigh, Jody, Kabacs, Nikolett, Haigh, Katharina, Sison, Karen, Costantini, Frank, ...

Here we describe a triple transgenic mouse system, which combines the tissue specificity of any Cre-transgenic line with the inducibility of the reverse tetracycline transactivator...

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction (2005)

Belteki, Gusztav, Haigh, Jody, Kabacs, Nikolett, Haigh, Katharina, Sison, Karen, Costantini, Frank, ...

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

Eremina, Vera, Sood, Manish, Haigh, Jody, Nagy, András, Lajoie, Ginette, Ferrara, Napoleone, ...

Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier is often the target of injury....

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Belteki, Gusztav, Haigh, Jody, Kabacs, Nikolett, Haigh, Katharina, Sison, Karen, Costantini, Frank, ...

Here we describe a triple transgenic mouse system, which combines the tissue specificity of any Cre-transgenic line with the inducibility of the reverse tetracycline transactivator...

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Belteki, Gusztav, Haigh, Jody, Kabacs, Nikolett, Haigh, Katharina, Sison, Karen, Costantini, Frank, ...

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

Eremina, Vera, Sood, Manish, Haigh, Jody, Nagy, András, Lajoie, Ginette, Ferrara, Napoleone, ...

Kidney disease affects over 20 million people in the United States alone. Although the causes of renal failure are diverse, the glomerular filtration barrier is often the target of injury....

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Belteki, Gusztav, Haigh, Jody, Kabacs, Nikolett, Haigh, Katharina, Sison, Karen, Costantini, Frank, ...

Here we describe a triple transgenic mouse system, which combines the tissue specificity of any Cre-transgenic line with the inducibility of the reverse tetracycline transactivator...

Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction

Belteki, Gusztav, Haigh, Jody, Kabacs, Nikolett, Haigh, Katharina, Sison, Karen, Costantini, Frank, ...

Large-scale identification of genes implicated in kidney glomerulus development and function

Takemoto, Minoru, He, Liqun, Norlin, Jenny, Patrakka, Jaakko, Xiao, Zhijie, Petrova, Tatiana, ...

To advance our understanding of development, function and diseases in the kidney glomerulus, we have established and large-scale sequenced cDNA libraries from mouse glomeruli at different stages of...

Sizing up sialic acid in glomerular disease

Quaggin, Susan E.

A new study by Galeano and colleagues in this issue of the JCI reports the first glomerular disease caused by a genetic defect in sialic acid biosynthesis (see the related article beginning on page...

Phosphorylated YDXV Motifs and Nck SH2/SH3 Adaptors Act Cooperatively To Induce Actin Reorganization▿

Blasutig, Ivan M., New, Laura A., Thanabalasuriar, Ajitha, Dayarathna, Thamara K., Goudreault, Marilyn, Quaggin, Susan E., ...

We have analyzed the means by which the Nck family of adaptor proteins couples adhesion proteins to actin reorganization. The nephrin adhesion protein is essential for the formation of actin-based...

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury

Heymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, ...

The progression of kidney disease to renal failure correlates with infiltration of mononuclear immune cells into the tubulointerstitium. These infiltrates contain macrophages, DCs, and T cells, but...

Ectopic Notch Activation in Developing Podocytes Causes Glomerulosclerosis

Waters, Aoife M., Wu, Megan Y.J., Onay, Tuncer, Scutaru, Jacob, Liu, Ju, Lobe, Corrinne G., ...

Genetic evidence supports an early role for Notch signaling in the fate of podocytes during glomerular development. Decreased expression of Notch transcriptional targets in developing podocytes after...

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury

Heymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, ...