Susan J. Borghoff

Tissue Exposures to Free and Glucuronidated Monobutylyphthalate in the Pregnant and Fetal Rat following Exposure to Di-n-butylphthalate: Evaluation with a PBPK Model (2008)

Clewell, Rebecca A., Kremer, John J., Williams, Carla C., Campbell, Jerry L., Andersen, Melvin E., Borghoff, Susan J.

Human exposure to phthalic acid diesters occurs through a variety of pathways as a result of their widespread use in plastics. Repeated doses of di-n-butylphthalate (DBP) from gestation day (GD) 12...

Kinetics of Genistein and Its Conjugated Metabolites in Pregnant Sprague-Dawley Rats Following Single and Repeated Genistein Administration (2006)

Soucy, Nicole V., Parkinson, Horace D., Sochaski, Mark A., Borghoff, Susan J.

Diets high in soy-based products are well known for their estrogenic activity. Genistein, the predominant phytoestrogen present in soy, is known to interact with estrogen receptors (ER) α and β and...

Kinetics of Genistein and its Conjugated Metabolites in Pregnant Sprague-Dawley Rats Following Single and Repeated Genistein Administration (2005)

Soucy, Nicole V., Parkinson, Horace D., Sochaski, Mark A., Borghoff, Susan J.

Diets high in soy-based products are well known for their estrogenic activity. Genistein, the predominant phytoestrogen present in soy, is known to interact with estrogen receptors (ER) α and β and...

Male Mice Deficient in Microsomal Epoxide Hydrolase are not Susceptible to Benzene-Induced Toxicity (2003)

Bauer, Alison K., Faiola, Brenda, Abernethy, Diane J., Marchan, Rosemarie, Pluta, Linda J., Wong, Victoria A., ...

Enzymes involved in benzene metabolism are likely genetic determinants of benzene-induced toxicity. Polymorphisms in human microsomal epoxide hydrolase (mEH) are associated with an increased risk of...

Male Mice Deficient in Microsomal Epoxide Hydrolase are not Susceptible to Benzene-Induced Toxicity (2003)

Bauer, Alison K., Faiola, Brenda, Abernethy, Diane J., Marchan, Rosemarie, Pluta, Linda J., Wong, Victoria A., ...

Enzymes involved in benzene metabolism are likely genetic determinants of benzene-induced toxicity. Polymorphisms in human microsomal epoxide hydrolase (mEH) are associated with an increased risk of...

A Physiologically Based Pharmacokinetic Model for Methyl tert-Butyl Ether in Humans: Implementing Sensitivity and Variability Analyses (2001)

Licata, Amy Collins, Dekant, Wolfgang, Smith, Charles E., Borghoff, Susan J.

Methyl tert-butyl ether (MTBE) is added to gasoline to reduce carbon monoxide and ozone precursors from automobile emissions. The objectives of this study were to verify the ability of a...

{{alpha}}2u-Globulin Nephropathy, Renal Cell Proliferation, and Dosimetry of Inhaled tert-Butyl Alcohol in Male and Female F-344 Rats (2001)

Borghoff, Susan J., Prescott, Judith S., Janszen, Derek B., Wong, Brian A., Everitt, Jeffery I.

tert-Butyl alcohol (TBA) has been shown to cause kidney tumors in male rats following chronic administration in drinking water. The objective of the present study was to determine whether TBA induces...

Alterations in Endocrine Responses in Male Sprague-Dawley Rats following Oral Administration of Methyl tert-Butyl Ether (2000)

Williams, Tracy M., Cattley, Russell C., Borghoff, Susan J.

Methyl tert-butyl ether (MTBE) is an oxygenated fuel additive used to decrease carbon monoxide emissions during combustion. MTBE is a nongenotoxic chemical that induces Leydig cell tumors (LCT) in...

Induction of Testosterone Biotransformation Enzymes following Oral Administration of Methyl tert-Butyl Ether to Male Sprague-Dawley Rats (2000)

Williams, Tracy M., Borghoff, Susan J.

Methyl tert-butyl ether (MTBE) is an oxygenated fuel additive used to decrease carbon monoxide emissions during gasoline combustion. In the current study, we investigated the hypothesis that the...

Development of a Mechanism-Based Dosimetry Model for 2,4,4-Trimethyl-2-pentanol-lnduced {alpha}2u-Globulin Nephropathy in Male Fischer 344 Rats (1995)

BORGHOFF, SUSAN J., GARGAS, MICHAEL L., ANDERSEN, MELVIN E., CONOLLY, RORY B.

A mechanism-based dosimetry model was developed to describe 2,4,4-trimethyl-2-pentanol (TMP-2-OH) dosimetry and renal α2u-globulin (α2u) nephropathy in the male Fischer 344 rat. Experimental data...