Lee, John S., Groebner, Jennifer L., Hadjipanayis, Angela G., Negley, Diane L., Schmaljohn, Alan L., Welkos, Susan L., ...
The development of multiagent vaccines offers the advantage of eliciting protection against multiple diseases with minimal inoculations over a shorter time span. We report here the results of using...
Recent Advances in the Development of an Improved, Human Anthrax Vaccine (2005)
Ivins, Bruce E., Welkos, Susan L.
Human anthrax vaccines currently licensed in the United States and Western Europe consist of alum-precipitated or aluminum hydroxide-absorbed supernatant material from fermentor cultures of...
Protective Efficacy and Safety of Live Anthrax Vaccines for Mice (2005)
The safety and protective efficacy of the Sterne vaccine strain of Bacillus anthracis and of a recombinant Bacillus subtilis strain were investigated in mice. Strains of mice which vary in their...
Differences in Susceptibility of Inbred Mice to Bacillus anthracis (2003)
Welkos, Susan L., Keener, Theresa J., Gibbs, Paul H.
Animal species differ in their resistance both to infection by B. anthracis and to anthrax toxin. A mouse model was developed to study the basis of these host differences and the pathogenesis of...
Ivins, Bruce E., Welkos, Susan L., Knudson, Gregory B., Little, Stephen F.
The safety and efficacy of five prototype, live anthrax vaccines were studied in Hartly guinea pigs and CBA/J and A/J mice. Two of the strains, Bacillus anthracis FD111 and FD112, are Aro-mutants...
Transponson Tn916 Mutagenesis in Bacillus anthracis, (1998)
Ivins, Bruce E., Welkos, Susan L., Knudson, Gregory B., LeBlanc, Donald J.
Mutagenesis of Bacillus anthracis by the streptococcal tetracycline resistance transponson, Tn916, is described. Tn916 was transferred from Streptococcus faecalis strain DS16C1 to B. anthracis VNR-1...
Cote, Christopher K., Van Rooijen, Nico, Welkos, Susan L.
The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We investigated the roles that macrophages and...
Antibiotic Treatment of Experimental Pneumonic Plague in Mice
Byrne, William R., Welkos, Susan L., Pitt, M. Louise, Davis, Kelly J., Brueckner, Ralf P., Ezzell, John W., ...
A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience....
Analysis of the Yersinia pestis V Protein for the Presence of Linear Antibody Epitopes
Pullen, Jeffrey K., Anderson, George W., Welkos, Susan L., Friedlander, Arthur M.
The V protein expressed by pathogenic Yersinia pestis is an important virulence factor and protective immunogen. The presence of linear B-cell epitopes in the V protein was investigated by using a...
Venezuelan Equine Encephalitis Virus-Vectored Vaccines Protect Mice against Anthrax Spore Challenge
Lee, John S., Hadjipanayis, Angela G., Welkos, Susan L.
Anthrax, a disease usually associated with herbivores, is caused by the bacterium Bacillus anthracis. The current vaccine licensed for human use requires a six-dose primary series and yearly boosters...
Cote, Christopher K., Van Rooijen, Nico, Welkos, Susan L.
The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We investigated the roles that macrophages and...
Immunochemical Studies of Diphtherial Toxin and Related Nontoxic Mutant Proteins
Cryz, Stanley J., Welkos, Susan L., Holmes, Randall K.
Competitive binding radioimmunoassays were used to analyze the immunochemistry of diphtherial toxin. Rabbit antisera obtained by immunization with formolized toxoid or fragment A were used to...
Antibiotic Treatment of Experimental Pneumonic Plague in Mice
Byrne, William R., Welkos, Susan L., Pitt, M. Louise, Davis, Kelly J., Brueckner, Ralf P., Ezzell, John W., ...
A mouse model was developed to evaluate the efficacy of antibiotic treatment of pneumonic plague; streptomycin was compared to antibiotics with which there is little or no clinical experience....
Analysis of the Yersinia pestis V Protein for the Presence of Linear Antibody Epitopes
Pullen, Jeffrey K., Anderson, George W., Welkos, Susan L., Friedlander, Arthur M.
The V protein expressed by pathogenic Yersinia pestis is an important virulence factor and protective immunogen. The presence of linear B-cell epitopes in the V protein was investigated by using a...
Venezuelan Equine Encephalitis Virus-Vectored Vaccines Protect Mice against Anthrax Spore Challenge
Lee, John S., Hadjipanayis, Angela G., Welkos, Susan L.
Anthrax, a disease usually associated with herbivores, is caused by the bacterium Bacillus anthracis. The current vaccine licensed for human use requires a six-dose primary series and yearly boosters...
Immunochemical Studies of Diphtherial Toxin and Related Nontoxic Mutant Proteins
Cryz, Stanley J., Welkos, Susan L., Holmes, Randall K.
Competitive binding radioimmunoassays were used to analyze the immunochemistry of diphtherial toxin. Rabbit antisera obtained by immunization with formolized toxoid or fragment A were used to...
Cote, Christopher K., Van Rooijen, Nico, Welkos, Susan L.
The development of new approaches to combat anthrax requires that the pathogenesis and host response to Bacillus anthracis spores be better understood. We investigated the roles that macrophages and...
Bozue, Joel, Moody, Krishna L., Cote, Christopher K., Stiles, Bradley G., Friedlander, Arthur M., Welkos, Susan L., ...
Bacillus anthracis is the causative agent of anthrax, and the spore form of the bacterium represents the infectious particle introduced into a host. The spore is surrounded by an exosporium, a...
In Vitro Intracellular Trafficking of Virulence Antigen during Infection by Yersinia pestis
DiMezzo, Tracy L., Ruthel, Gordon, Brueggemann, Ernst E., Hines, Harry B., Ribot, Wilson J., Chapman, Carol E., ...
Yersinia pestis, the causative agent of plague, encodes several essential virulence factors on a 70 kb plasmid, including the Yersinia outer proteins (Yops) and a multifunctional virulence antigen...