Wu, Haiyan, Yuan, Ming, Kaech, Susan M., Halloran, M. Elizabeth
CD8 T cells are specialized immune cells that play an important role in the regulation of antiviral immune response and the generation of protective immunity. In this paper we investigate the...
Enhanced Expression of Cell Cycle Regulatory Genes in Virus-Specific (2004)
Memory Cd, T Cells, Donald R. Latner, Susan M. Kaech, Rafi Ahmed
Unlike naive CD8 � T cells, antigen-experienced memory CD8 � T cells persist over time due to their unique ability to homeostatically proliferate. It was hypothesized that memory cells might...
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...
Enhanced Expression of Cell Cycle Regulatory Genes in Virus-Specific Memory CD8+ T Cells
Latner, Donald R., Kaech, Susan M., Ahmed, Rafi
Unlike naive CD8+ T cells, antigen-experienced memory CD8+ T cells persist over time due to their unique ability to homeostatically proliferate. It was hypothesized that memory cells might...
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. John, Barber, Daniel L., Kaech, Susan M., Blattman, Joseph N., Ahmed, Rafi
Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting...
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes
Manders, Peter M., Hunter, Patricia J., Telaranta, Aino I., Carr, James M., Marshall, Jennifer L., Carrasco, Marlene, ...
A characteristic of the secondary response of CD8+ T cells that distinguishes it from the primary response is the generation of greater numbers of effector cells. Because effector CD8+ T cells are...
Heterologous immunity provides a potent barrier to transplantation tolerance
Adams, Andrew B., Williams, Matthew A., Jones, Thomas R., Shirasugi, Nozomu, Durham, Megan M., Kaech, Susan M., ...
Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We...
Enhanced Expression of Cell Cycle Regulatory Genes in Virus-Specific Memory CD8+ T Cells
Latner, Donald R., Kaech, Susan M., Ahmed, Rafi
Unlike naive CD8+ T cells, antigen-experienced memory CD8+ T cells persist over time due to their unique ability to homeostatically proliferate. It was hypothesized that memory cells might...
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. John, Barber, Daniel L., Kaech, Susan M., Blattman, Joseph N., Ahmed, Rafi
Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting...
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes
Manders, Peter M., Hunter, Patricia J., Telaranta, Aino I., Carr, James M., Marshall, Jennifer L., Carrasco, Marlene, ...
A characteristic of the secondary response of CD8+ T cells that distinguishes it from the primary response is the generation of greater numbers of effector cells. Because effector CD8+ T cells are...
Hand, Timothy W., Morre, Michel, Kaech, Susan M.
During many acute viral and bacterial infections, IL-7 receptor α-chain (IL-7Rα) is expressed on a subset of effector CD8 T cells that preferentially develop into long-lived memory CD8 T cells....
Estimating the Precursor Frequency of Naive Antigen-specific CD8 T Cells
Blattman, Joseph N., Antia, Rustom, Sourdive, David J.D., Wang, Xiaochi, Kaech, Susan M., Murali-Krishna, Kaja, ...
The constraint of fitting a diverse repertoire of antigen specificities in a limited total population of lymphocytes results in the frequency of naive cells specific for any given antigen (defined as...