Susan W. Barnett

Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences (2005)

Scriba, Thomas Jens, Zur Megede, Jan, Glashoff, Richard H., Treurnicht, Florette K., Barnett, Susan W., Janse Van Rensburg, Estrelita

The efficacy of cellular immune responses elicited by HIV vaccines is dependent on their strength, durability and antigenic breadth. The regulatory proteins are abundantly expressed early in the...

Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences (2005)

Scriba, Thomas Jens, Zur Megede, Jan, Glashoff, Richard H., Treurnicht, Florette K., Barnett, Susan W., Janse Van Rensburg, Estrelita

The efficacy of cellular immune responses elicited by HIV vaccines is dependent on their strength, durability and antigenic breadth. The regulatory proteins are abundantly expressed early in the...

Novel evolutionary analyses of full-length HIV type 1 subtype C molecular clones from Cape Town South Africa (2002)

Zur Megede, Jan, Engelbrecht, Susan, De Oliveira, Tulio, Cassol, Sharon, Scriba, Thomas Jens, Janse Van Rensburg, Estrelita, ...

The publisher does not allow open access to the full text of this item. If you however need access to the full text, please contact the Collection Administrator, or access the item via the e-journal...

Novel evolutionary analyses of full-length HIV type 1 subtype C molecular clones from Cape Town South Africa (2002)

Zur Megede, Jan, Engelbrecht, Susan, De Oliveira, Tulio, Cassol, Sharon, Scriba, Thomas Jens, Janse Van Rensburg, Estrelita, ...

The publisher does not allow open access to the full text of this item. If you however need access to the full text, please contact the Collection Administrator, or access the item via the e-journal...

Genetic analysis of the complete gag and env genes of HIV type 1 subtype C primary isolates from South Africa (2001)

Engelbrecht, Susan, De Villiers, Tania, Sampson, Candice C., Zur Megede, Jan, Barnett, Susan W., Janse Van Rensburg, Estrelita

The publisher does not allow open access to the full text of this sequence note. If you however need access to the full text, please contact the Collection Administrator, or access the item via the...

Genetic analysis of the complete gag and env genes of HIV type 1 subtype C primary isolates from South Africa (2001)

Engelbrecht, Susan, De Villiers, Tania, Sampson, Candice C., Zur Megede, Jan, Barnett, Susan W., Janse Van Rensburg, Estrelita

The publisher does not allow open access to the full text of this sequence note. If you however need access to the full text, please contact the Collection Administrator, or access the item via the...

Comparison of Immunity Generated by Nucleic Acid-, MF59-, and ISCOM-Formulated Human Immunodeficiency Virus Type 1 Vaccines in Rhesus Macaques: Evidence for Viral Clearance

Verschoor, Ernst J., Mooij, Petra, Oostermeijer, Herman, Van Der Kolk, Mike, Ten Haaft, Peter, Verstrepen, Babs, ...

The kinetics of T-helper immune responses generated in 16 mature outbred rhesus monkeys (Macaca mulatta) within a 10-month period by three different human immunodeficiency virus type 1 (HIV-1)...

Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene

Zur Megede, Jan, Chen, Min-Chao, Doe, Barbara, Schaefer, Mary, Greer, Catherine E., Selby, Mark, ...

A major challenge for the next generation of human immunodeficiency virus (HIV) vaccines is the induction of potent, broad, and durable cellular immune responses. The structural protein Gag is highly...

Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein

Gardner, Jason P., Frolov, Ilya, Perri, Silvia, Ji, Yaying, MacKichan, Mary Lee, Zur Megede, Jan, ...

The ability to target antigen-presenting cells with vectors encoding desired antigens holds the promise of potent prophylactic and therapeutic vaccines for infectious diseases and cancer. Toward this...

Purification and Characterization of Oligomeric Envelope Glycoprotein from a Primary R5 Subtype B Human Immunodeficiency Virus

Srivastava, Indresh K., Stamatatos, Leonidas, Legg, Harold, Kan, Elaine, Fong, Anne, Coates, Stephen R., ...

Human immunodeficiency virus (HIV) continues to be a major public health problem throughout the world, with high levels of mortality and morbidity associated with AIDS. Considerable efforts to...

Changes in the Immunogenic Properties of Soluble gp140 Human Immunodeficiency Virus Envelope Constructs upon Partial Deletion of the Second Hypervariable Region

Srivastava, Indresh K., VanDorsten, Keating, Vojtech, Lucia, Barnett, Susan W., Stamatatos, Leonidas

Immunization of macaques with the soluble oligomeric gp140 form of the SF162 envelope (SF162gp140) or with an SF162gp140-derived construct lacking the central region of the V2 loop (ΔV2gp140)...

Induction of Broad and Potent Anti-Human Immunodeficiency Virus Immune Responses in Rhesus Macaques by Priming with a DNA Vaccine and Boosting with Protein-Adsorbed Polylactide Coglycolide Microparticles

Otten, Gillis, Schaefer, Mary, Greer, Catherine, Calderon-Cacia, Maria, Coit, Doris, Kazzaz, Jina, ...

Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad...

Variability at Human Immunodeficiency Virus Type 1 Subtype C Protease Cleavage Sites: an Indication of Viral Fitness?

De Oliveira, Tulio, Engelbrecht, Susan, Janse Van Rensburg, Estrelita, Gordon, Michelle, Bishop, Karen, Zur Megede, Jan, ...

Naturally occurring polymorphisms in the protease of human immunodeficiency virus type 1 (HIV-1) subtype C would be expected to lead to adaptive (compensatory) changes in protease cleavage sites. To...

Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 Isolate

Srivastava, Indresh K., Stamatatos, Leonidas, Kan, Elaine, Vajdy, Michael, Lian, Ying, Hilt, Susan, ...

The envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is the major target of neutralizing antibody responses and is likely to be a critical component of an effective vaccine...

Developmental regulation by an enhancer from the Sgs-4 gene of Drosophila

Shermoen, Antony W., Jongens, Jill, Barnett, Susan W., Flynn, Kathleen, Beckendorf, Steven K.

A cis acting regulatory region has previously been identified 300-500 bp upstream of the Drosophila glue protein gene, Sgs-4. The functional capabilities of this region have now been examined by...

Replicating Rather than Nonreplicating Adenovirus-Human Immunodeficiency Virus Recombinant Vaccines Are Better at Eliciting Potent Cellular Immunity and Priming High-Titer Antibodies

Peng, Bo, Wang, Liqun Rejean, Gómez-Román, Victor Raúl, Davis-Warren, Alberta, Montefiori, David C., Kalyanaraman, V. S., ...

A major challenge in combating the human immunodeficiency virus (HIV) epidemic is the development of vaccines capable of inducing potent, persistent cellular immunity and broadly reactive...

Evaluation of Envelope Vaccines Derived from the South African Subtype C Human Immunodeficiency Virus Type 1 TV1 Strain

Lian, Ying, Srivastava, Indresh, Gómez-Román, V. Rául, Zur Megede, Jan, Sun, Yide, Kan, Elaine, ...

Human immunodeficiency virus type 1 (HIV-1) subtype C infections are on the rise in Sub-Saharan Africa and Asia. Therefore, there is a need to develop an HIV vaccine capable of eliciting broadly...

Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 Subtype B pol and gagpol DNA Vaccines

Zur Megede, Jan, Otten, Gillis R., Doe, Barbara, Liu, Hong, Leung, Louisa, Ulmer, Jeffrey B., ...

Control of the worldwide AIDS pandemic may require not only preventive but also therapeutic immunization strategies. To meet this challenge, the next generation of human immunodeficiency virus type 1...

Comparison of Immunity Generated by Nucleic Acid-, MF59-, and ISCOM-Formulated Human Immunodeficiency Virus Type 1 Vaccines in Rhesus Macaques: Evidence for Viral Clearance

Verschoor, Ernst J., Mooij, Petra, Oostermeijer, Herman, Van Der Kolk, Mike, Ten Haaft, Peter, Verstrepen, Babs, ...

The kinetics of T-helper immune responses generated in 16 mature outbred rhesus monkeys (Macaca mulatta) within a 10-month period by three different human immunodeficiency virus type 1 (HIV-1)...

Increased Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 gag Gene

Zur Megede, Jan, Chen, Min-Chao, Doe, Barbara, Schaefer, Mary, Greer, Catherine E., Selby, Mark, ...

A major challenge for the next generation of human immunodeficiency virus (HIV) vaccines is the induction of potent, broad, and durable cellular immune responses. The structural protein Gag is highly...

Infection of Human Dendritic Cells by a Sindbis Virus Replicon Vector Is Determined by a Single Amino Acid Substitution in the E2 Glycoprotein

Gardner, Jason P., Frolov, Ilya, Perri, Silvia, Ji, Yaying, MacKichan, Mary Lee, Zur Megede, Jan, ...

The ability to target antigen-presenting cells with vectors encoding desired antigens holds the promise of potent prophylactic and therapeutic vaccines for infectious diseases and cancer. Toward this...

Purification and Characterization of Oligomeric Envelope Glycoprotein from a Primary R5 Subtype B Human Immunodeficiency Virus

Srivastava, Indresh K., Stamatatos, Leonidas, Legg, Harold, Kan, Elaine, Fong, Anne, Coates, Stephen R., ...

Human immunodeficiency virus (HIV) continues to be a major public health problem throughout the world, with high levels of mortality and morbidity associated with AIDS. Considerable efforts to...

Changes in the Immunogenic Properties of Soluble gp140 Human Immunodeficiency Virus Envelope Constructs upon Partial Deletion of the Second Hypervariable Region

Srivastava, Indresh K., VanDorsten, Keating, Vojtech, Lucia, Barnett, Susan W., Stamatatos, Leonidas

Immunization of macaques with the soluble oligomeric gp140 form of the SF162 envelope (SF162gp140) or with an SF162gp140-derived construct lacking the central region of the V2 loop (ΔV2gp140)...

Induction of Broad and Potent Anti-Human Immunodeficiency Virus Immune Responses in Rhesus Macaques by Priming with a DNA Vaccine and Boosting with Protein-Adsorbed Polylactide Coglycolide Microparticles

Otten, Gillis, Schaefer, Mary, Greer, Catherine, Calderon-Cacia, Maria, Coit, Doris, Kazzaz, Jina, ...

Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad...

Expression and Immunogenicity of Sequence-Modified Human Immunodeficiency Virus Type 1 Subtype B pol and gagpol DNA Vaccines

Zur Megede, Jan, Otten, Gillis R., Doe, Barbara, Liu, Hong, Leung, Louisa, Ulmer, Jeffrey B., ...

Control of the worldwide AIDS pandemic may require not only preventive but also therapeutic immunization strategies. To meet this challenge, the next generation of human immunodeficiency virus type 1...

Variability at Human Immunodeficiency Virus Type 1 Subtype C Protease Cleavage Sites: an Indication of Viral Fitness?

De Oliveira, Tulio, Engelbrecht, Susan, Janse Van Rensburg, Estrelita, Gordon, Michelle, Bishop, Karen, Zur Megede, Jan, ...

Naturally occurring polymorphisms in the protease of human immunodeficiency virus type 1 (HIV-1) subtype C would be expected to lead to adaptive (compensatory) changes in protease cleavage sites. To...

Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 Isolate

Srivastava, Indresh K., Stamatatos, Leonidas, Kan, Elaine, Vajdy, Michael, Lian, Ying, Hilt, Susan, ...

The envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is the major target of neutralizing antibody responses and is likely to be a critical component of an effective vaccine...

Developmental regulation by an enhancer from the Sgs-4 gene of Drosophila

Shermoen, Antony W., Jongens, Jill, Barnett, Susan W., Flynn, Kathleen, Beckendorf, Steven K.

A cis acting regulatory region has previously been identified 300-500 bp upstream of the Drosophila glue protein gene, Sgs-4. The functional capabilities of this region have now been examined by...

Replicating Rather than Nonreplicating Adenovirus-Human Immunodeficiency Virus Recombinant Vaccines Are Better at Eliciting Potent Cellular Immunity and Priming High-Titer Antibodies

Peng, Bo, Wang, Liqun Rejean, Gómez-Román, Victor Raúl, Davis-Warren, Alberta, Montefiori, David C., Kalyanaraman, V. S., ...

A major challenge in combating the human immunodeficiency virus (HIV) epidemic is the development of vaccines capable of inducing potent, persistent cellular immunity and broadly reactive...

Evaluation of Envelope Vaccines Derived from the South African Subtype C Human Immunodeficiency Virus Type 1 TV1 Strain

Lian, Ying, Srivastava, Indresh, Gómez-Román, V. Rául, Zur Megede, Jan, Sun, Yide, Kan, Elaine, ...

Human immunodeficiency virus type 1 (HIV-1) subtype C infections are on the rise in Sub-Saharan Africa and Asia. Therefore, there is a need to develop an HIV vaccine capable of eliciting broadly...

β7-integrin-independent enhancement of mucosal and systemic anti-HIV antibody responses following combined mucosal and systemic gene delivery

Goodsell, Amanda, Zhou, Fengmin, Gupta, Soumi, Singh, Manmohan, Malyala, Padma, Kazzaz, Jina, ...

Vaccination strategies that can block or limit heterosexual human immunodeficiency virus (HIV) transmissions to local and systemic tissues are the goal of much research effort. Herein, in a mouse...