Susan Wimer-Mackin

Anthrax Toxin Entry into Polarized Epithelial Cells

Beauregard, Kathryn E., Wimer-Mackin, Susan, Collier, R. John, Lencer, Wayne I.

We examined the entry of anthrax edema toxin (EdTx) into polarized human T84 epithelial cells using cyclic AMP-regulated Cl− secretion as an index of toxin entry. EdTx is a binary A/B toxin which...

Association of Protease Activity in Vibrio cholerae Vaccine Strains with Decreases in Transcellular Epithelial Resistance of Polarized T84 Intestinal Epithelial Cells

Mel, Stephanie F., Fullner, Karla Jean, Wimer-Mackin, Susan, Lencer, Wayne I., Mekalanos, John J.

Culture supernatants prepared from reactogenic strains of Vibrio cholerae cause a decrease in the transcellular epithelial resistance of T84 intestinal cells. This decrease correlates with the...

Characterization of Receptor-Mediated Signal Transduction by Escherichia coli Type IIa Heat-Labile Enterotoxin in the Polarized Human Intestinal Cell Line T84

Wimer-Mackin, Susan, Holmes, Randall K., Wolf, Anne A., Lencer, Wayne I., Jobling, Michael G.

Escherichia coli type IIa heat-labile enterotoxin (LTIIa) binds in vitro with highest affinity to ganglioside GD1b. It also binds in vitro with lower affinity to several other oligosialogangliosides...

Anthrax Toxin Entry into Polarized Epithelial Cells

Beauregard, Kathryn E., Wimer-Mackin, Susan, Collier, R. John, Lencer, Wayne I.

We examined the entry of anthrax edema toxin (EdTx) into polarized human T84 epithelial cells using cyclic AMP-regulated Cl− secretion as an index of toxin entry. EdTx is a binary A/B toxin which...

Association of Protease Activity in Vibrio cholerae Vaccine Strains with Decreases in Transcellular Epithelial Resistance of Polarized T84 Intestinal Epithelial Cells

Mel, Stephanie F., Fullner, Karla Jean, Wimer-Mackin, Susan, Lencer, Wayne I., Mekalanos, John J.

Culture supernatants prepared from reactogenic strains of Vibrio cholerae cause a decrease in the transcellular epithelial resistance of T84 intestinal cells. This decrease correlates with the...

Characterization of Receptor-Mediated Signal Transduction by Escherichia coli Type IIa Heat-Labile Enterotoxin in the Polarized Human Intestinal Cell Line T84

Wimer-Mackin, Susan, Holmes, Randall K., Wolf, Anne A., Lencer, Wayne I., Jobling, Michael G.

Escherichia coli type IIa heat-labile enterotoxin (LTIIa) binds in vitro with highest affinity to ganglioside GD1b. It also binds in vitro with lower affinity to several other oligosialogangliosides...

Ganglioside Structure Dictates Signal Transduction by Cholera Toxin and Association with Caveolae-like Membrane Domains in Polarized Epithelia

Wolf, Anne A., Jobling, Michael G., Wimer-Mackin, Susan, Ferguson-Maltzman, Margaret, Madara, James L., Holmes, Randall K., ...

In polarized cells, signal transduction by cholera toxin (CT) requires apical endocytosis and retrograde transport into Golgi cisternae and perhaps ER (Lencer, W.I., C. Constable, S. Moe, M. Jobling,...