Tim F. Cooper, Susanna K. Remold, Richard E. Lenski, Dominique Schneider
The extent and nature of epistatic interactions between mutations are issues of fundamental importance in evolutionary biology. However, they are difficult to study and their influence on adaptation...
Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus (2008)
Remold, Susanna K., Rambaut, Andrew, Turner, Paul E.
Populations experiencing similar selection pressures can sometimes diverge in the genetic architectures underlying evolved complex traits. We used RNA virus populations of large size and high...
Evolution of Mutational Robustness in an RNA Virus (2005)
Rebecca Montville, Remy Froissart, Susanna K. Remold, Olivier Tenaillon, Paul E. Turner
RNA phage viruses evolved under high co-infection of host cells are less robust to mutations than those propagated under low co-infection, suggesting that co-infection may be advantageous to RNA...
Evolution of Mutational Robustness in an RNA Virus (2005)
Rebecca Montville, Remy Froissart, Susanna K. Remold, Olivier Tenaillon, Paul E. Turner
Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed...
Remold, Susanna K., Lenski, Richard E.
Numerous studies have shown genotype-by-environment (G×E) interactions for traits related to organismal fitness. However, the genetic architecture of the interaction is usually unknown because these...
Evolution of Mutational Robustness in an RNA Virus
Montville, Rebecca, Froissart, Remy, Remold, Susanna K, Tenaillon, Olivier, Turner, Paul E
Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed...
Co-infection Weakens Selection Against Epistatic Mutations in RNA Viruses
Froissart, Rémy, Wilke, Claus O., Montville, Rebecca, Remold, Susanna K., Chao, Lin, Turner, Paul E.
Co-infection may be beneficial in large populations of viruses because it permits sexual exchange between viruses that is useful in combating the mutational load. This advantage of sex should be...
Remold, Susanna K., Lenski, Richard E.
Numerous studies have shown genotype-by-environment (G×E) interactions for traits related to organismal fitness. However, the genetic architecture of the interaction is usually unknown because these...
Evolution of Mutational Robustness in an RNA Virus
Montville, Rebecca, Froissart, Remy, Remold, Susanna K, Tenaillon, Olivier, Turner, Paul E
Mutational (genetic) robustness is phenotypic constancy in the face of mutational changes to the genome. Robustness is critical to the understanding of evolution because phenotypically expressed...
Co-infection Weakens Selection Against Epistatic Mutations in RNA Viruses
Froissart, Rémy, Wilke, Claus O., Montville, Rebecca, Remold, Susanna K., Chao, Lin, Turner, Paul E.
Co-infection may be beneficial in large populations of viruses because it permits sexual exchange between viruses that is useful in combating the mutational load. This advantage of sex should be...
Cooper, Tim F, Remold, Susanna K, Lenski, Richard E, Schneider, Dominique
The extent and nature of epistatic interactions between mutations are issues of fundamental importance in evolutionary biology. However, they are difficult to study and their influence on adaptation...
Evolution of Highly Polymorphic T Cell Populations in Siblings with the Wiskott-Aldrich Syndrome
Lutskiy, Maxim I., Park, Jun Y., Remold, Susanna K., Remold-O'Donnell, Eileen
Population level evolutionary processes can occur within a single organism when the germ line contains a mutation that confers a cost at the level of the cell. Here we describe how multiple...