Susanna Ricci

Method for inducing experimental pneumococcal meningitis in outbred mice (2004)

Chiavolini, Damiana, Tripodi, Sergio, Parigi, Riccardo, Oggioni, Marco R, Blasi, Elisabetta, Cintorino, Marcella, ...

Abstract Background Streptococcus pneumoniae is the leading cause of bacterial meningitis. Pneumococcal meningitis is associated with the highest mortality among bacterial meningitis and it may also...

In vivomucosal delivery of bioactive human interleukin 1 receptor antagonist produced by Streptococcus gordonii (2003)

Ricci, Susanna, Macchia, Giovanni, Ruggiero, Paolo, Maggi, Tiziana, Bossù, Paola, Xu, Li, ...

Abstract Background Interleukin-1 (IL-1) is a cytokine involved in the initiation and amplification of the defence response in infectious and inflammatory diseases. IL-1 receptor antagonist (IL-1ra)...

The regulator PerR is involved in oxidative stress response and iron homeostasis and is necessary for full virulence of Streptococcus pyogenes. (2002)

Ricci, Susanna, Janulczyk, Robert, Björck, Lars

Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the...

Immunogenicity of the B Monomer of Escherichia coli Heat-Labile Toxin Expressed on the Surface of Streptococcus gordonii

Ricci, Susanna, Medaglini, Donata, Rush, Catherine M., Marcello, Alessandro, Peppoloni, Samuele, Manganelli, Riccardo, ...

The B monomer of the Escherichia coli heat-labile toxin (LTB) was expressed on the surface of the human oral commensal bacterium Streptococcus gordonii. Recombinant bacteria expressing LTB were used...

The Regulator PerR Is Involved in Oxidative Stress Response and Iron Homeostasis and Is Necessary for Full Virulence of Streptococcus pyogenes

Ricci, Susanna, Janulczyk, Robert, Björck, Lars

Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the...

MtsABC Is Important for Manganese and Iron Transport, Oxidative Stress Resistance, and Virulence of Streptococcus pyogenes

Janulczyk, Robert, Ricci, Susanna, Björck, Lars

MtsABC is a Streptococcus pyogenes ABC transporter which was previously shown to be involved in iron and zinc accumulation. In this study, we showed that an mtsABC mutant has impaired growth,...

Pneumococcal Surface Protein C Contributes to Sepsis Caused by Streptococcus pneumoniae in Mice

Iannelli, Francesco, Chiavolini, Damiana, Ricci, Susanna, Oggioni, Marco Rinaldo, Pozzi, Gianni

The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in...

Antibacterial Activity of a Competence-Stimulating Peptide in Experimental Sepsis Caused by Streptococcus pneumoniae

Oggioni, Marco R., Iannelli, Francesco, Ricci, Susanna, Chiavolini, Damiana, Parigi, Riccardo, Trappetti, Claudia, ...

Streptococcus pneumoniae, a major cause of human disease, produces a 17-mer autoinducer peptide pheromone (competence-stimulating peptide [CSP]) for the control of competence for genetic...

In Vivo Activation of Naive CD4+ T Cells in Nasal Mucosa-Associated Lymphoid Tissue following Intranasal Immunization with Recombinant Streptococcus gordonii

Medaglini, Donata, Ciabattini, Annalisa, Cuppone, Anna Maria, Costa, Caterina, Ricci, Susanna, Costalonga, Massimo, ...

The antigen-specific primary activation of CD4+ T cells was studied in vivo by adoptive transfer of ovalbumin-specific transgenic T cells (KJ1-26+ CD4+) following intranasal immunization with...

Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis

Oggioni, Marco R, Trappetti, Claudia, Kadioglu, Aras, Cassone, Marco, Iannelli, Francesco, Ricci, Susanna, ...

Two main patterns of gene expression of Streptococcus pneumoniae were observed during infection in the host by quantitative real time RT-PCR; one was characteristic of bacteria in blood and one of...

Immunogenicity of the B Monomer of Escherichia coli Heat-Labile Toxin Expressed on the Surface of Streptococcus gordonii

Ricci, Susanna, Medaglini, Donata, Rush, Catherine M., Marcello, Alessandro, Peppoloni, Samuele, Manganelli, Riccardo, ...

The B monomer of the Escherichia coli heat-labile toxin (LTB) was expressed on the surface of the human oral commensal bacterium Streptococcus gordonii. Recombinant bacteria expressing LTB were used...

The Regulator PerR Is Involved in Oxidative Stress Response and Iron Homeostasis and Is Necessary for Full Virulence of Streptococcus pyogenes

Ricci, Susanna, Janulczyk, Robert, Björck, Lars

Ferric uptake regulator (Fur) and Fur-like proteins form an important family of transcriptional regulators in many bacterial species. In this work we have characterized a Fur-like protein, the...

MtsABC Is Important for Manganese and Iron Transport, Oxidative Stress Resistance, and Virulence of Streptococcus pyogenes

Janulczyk, Robert, Ricci, Susanna, Björck, Lars

MtsABC is a Streptococcus pyogenes ABC transporter which was previously shown to be involved in iron and zinc accumulation. In this study, we showed that an mtsABC mutant has impaired growth,...

Pneumococcal Surface Protein C Contributes to Sepsis Caused by Streptococcus pneumoniae in Mice

Iannelli, Francesco, Chiavolini, Damiana, Ricci, Susanna, Oggioni, Marco Rinaldo, Pozzi, Gianni

The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in...

Antibacterial Activity of a Competence-Stimulating Peptide in Experimental Sepsis Caused by Streptococcus pneumoniae

Oggioni, Marco R., Iannelli, Francesco, Ricci, Susanna, Chiavolini, Damiana, Parigi, Riccardo, Trappetti, Claudia, ...

Streptococcus pneumoniae, a major cause of human disease, produces a 17-mer autoinducer peptide pheromone (competence-stimulating peptide [CSP]) for the control of competence for genetic...

In Vivo Activation of Naive CD4+ T Cells in Nasal Mucosa-Associated Lymphoid Tissue following Intranasal Immunization with Recombinant Streptococcus gordonii

Medaglini, Donata, Ciabattini, Annalisa, Cuppone, Anna Maria, Costa, Caterina, Ricci, Susanna, Costalonga, Massimo, ...

The antigen-specific primary activation of CD4+ T cells was studied in vivo by adoptive transfer of ovalbumin-specific transgenic T cells (KJ1-26+ CD4+) following intranasal immunization with...

Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis

Oggioni, Marco R, Trappetti, Claudia, Kadioglu, Aras, Cassone, Marco, Iannelli, Francesco, Ricci, Susanna, ...

Two main patterns of gene expression of Streptococcus pneumoniae were observed during infection in the host by quantitative real time RT-PCR; one was characteristic of bacteria in blood and one of...

Animal Models of Streptococcus pneumoniae Disease

Chiavolini, Damiana, Pozzi, Gianni, Ricci, Susanna

Summary: Streptococcus pneumoniae is a colonizer of human nasopharynx, but it is also an important pathogen responsible for high morbidity, high mortality, numerous disabilities, and high health...