Copy number variation influences gene expression and metabolic traits in mice (2009)
Orozco, Luz D., Cokus, Shawn J., Ghazalpour, Anatole, Ingram-Drake, Leslie, Wang, Susanna, Van Nas, Atila, ...
Copy number variants (CNVs) are genomic segments which are duplicated or deleted among different individuals. CNVs have been implicated in both Mendelian and complex traits, including immune and...
Mapping the Genetic Architecture of Gene Expression in Human Liver (2008)
Eric E. Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y. Lum, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...
Anatole Ghazalpour, Sudheer Doss, Xia Yang, Jason Aten, Edward M. Toomey, Atila Van Nas, ...
thematic review
Supplemental Material can be found at: (2008)
Anatole Ghazalpour, Sudheer Doss, Xia Yang, Jason Aten, Edward M. Toomey, Atila Van, ...
Key words: systems biology; transgenic mice; quantitative trait locus mapping; principal components; Bayesian networks; correlation coefficients; genetics; genomics; proteomics Correspondence:
Dosage compensation is less effective in birds than in mammals (2007)
Itoh, Yuichiro, Melamed, Esther, Yang, Xia, Kampf, Kathy, Wang, Susanna, Yehya, Nadir, ...
Abstract Background In animals with heteromorphic sex chromosomes, dosage compensation of sex-chromosome genes is thought to be critical for species survival. Diverse molecular mechanisms have...
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight (2006)
Anatole Ghazalpour, Sudheer Doss, Bin Zhang, Susanna Wang, Christopher Plaisier, Ruth Castellanos, ...
Systems biology approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. We use microarray and genetic marker...
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight (2006)
Anatole Ghazalpour, Sudheer Doss, Bin Zhang, Susanna Wang, Christopher Plaisier, Ruth Castellanos, ...
Gene mapping approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. Recently, several groups have proposed...
Susanna Wang, Nadir Yehya, Eric E. Schadt, Hui Wang, Thomas A. Drake, Aldons J. Lusis
The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...
Tissue-specific expression and regulation of sexually dimorphic genes in mice (2006)
Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....
Tissue-specific expression and regulation of sexually dimorphic genes in mice (2006)
Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....
The Role of the Arabidopsis ELD1 Gene in Cell Development and Photomorphogenesis in Darkness1
Cheng, Jin-Chen, Lertpiriyapong, Kvin, Wang, Susanna, Sung, Zinmay Renee
Because cell growth and differentiation are regulated by complex interactions among different signaling pathways, a growth defect affects subsequent differentiation. We report on a growth-defective...
Wang, Susanna, Yehya, Nadir, Schadt, Eric E, Wang, Hui, Drake, Thomas A, Lusis, Aldons J
The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight
Ghazalpour, Anatole, Doss, Sudheer, Zhang, Bin, Wang, Susanna, Plaisier, Christopher, Castellanos, Ruth, ...
Systems biology approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. We use microarray and genetic marker...
The Role of the Arabidopsis ELD1 Gene in Cell Development and Photomorphogenesis in Darkness1
Cheng, Jin-Chen, Lertpiriyapong, Kvin, Wang, Susanna, Sung, Zinmay Renee
Because cell growth and differentiation are regulated by complex interactions among different signaling pathways, a growth defect affects subsequent differentiation. We report on a growth-defective...
Wang, Susanna, Yehya, Nadir, Schadt, Eric E, Wang, Hui, Drake, Thomas A, Lusis, Aldons J
The integration of expression profiling with linkage analysis has increasingly been used to identify genes underlying complex phenotypes. The effects of gender on the regulation of many physiological...
Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight
Ghazalpour, Anatole, Doss, Sudheer, Zhang, Bin, Wang, Susanna, Plaisier, Christopher, Castellanos, Ruth, ...
Systems biology approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. We use microarray and genetic marker...
Tissue-specific expression and regulation of sexually dimorphic genes in mice
Yang, Xia, Schadt, Eric E., Wang, Susanna, Wang, Hui, Arnold, Arthur P., Ingram-Drake, Leslie, ...
We report a comprehensive analysis of gene expression differences between sexes in multiple somatic tissues of 334 mice derived from an intercross between inbred mouse strains C57BL/6J and C3H/HeJ....
Dosage compensation is less effective in birds than in mammals
Itoh, Yuichiro, Melamed, Esther, Yang, Xia, Kampf, Kathy, Wang, Susanna, Yehya, Nadir, ...
Mapping the Genetic Architecture of Gene Expression in Human Liver
Schadt, Eric E, Molony, Cliona, Chudin, Eugene, Hao, Ke, Yang, Xia, Lum, Pek Y, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...