Regular homotopic deformation of compact surface with boundary and mapping class group (2009)
Hirose, Susumu, Yasuhara, Akira
A necessary and sufficient algebraic condition for a diffeomorphism over a surface embedded in the 3-sphere to be induced by a regular homotopic deformation is discussed, and a formula for the number...
Realization of the mapping class group of handlebody by diffeomorphisms (2009)
For the oriented 3-dimensional handlebody constructed from a 3-ball by attaching g 1-handles, it is shown that the natural surjection from the group of orientation preserving diffeomorphisms of it to...
Midline governs axon pathfinding by coordinating expression of two major guidance systems (2009)
Liu, Qing-Xin, Hiramoto, Masaki, Ueda, Hitoshi, Gojobori, Takashi, Hiromi, Yasushi, Hirose, Susumu
Formation of the neural network requires concerted action of multiple axon guidance systems. How neurons orchestrate expression of multiple guidance genes is poorly understood. Here, we show that...
structure of the transcriptional coactivator (2008)
Jun Ozaki, Ken-ichi Takemaru, Takahisa Ikegami, Masaki Mishima, Hitoshi Ueda, Susumu Hirose, ...
Identification of the core domain and the secondary
Agawa, Yasuo, Sarhan, Moustafa, Kageyama, Yuji, Akagi, Kazutaka, Takai, Masayoshi, Hashiyama, Kazuya, ...
Regulatory mechanisms controlling the timing of developmental events are crucial for proper development to occur. ftz-fl is expressed in a temporally regulated manner following pulses of ecdysteroid...
Liu, Qing-Xin, Nakashima-Kamimura, Naomi, Ikeo, Kazuho, Hirose, Susumu, Gojobori, Takashi
To elucidate the transcriptional regulation in eukaryotic genome network, it is important to understand coevolution of transcription factors, transcriptional coactivators, and TATA-box–binding...
Crucial Roles for Chromatin Dynamics in Cellular Memory (2007)
Cellular memory is defined as a long-term maintenance of a particular pattern of gene expression through many rounds of cell division or even after cell division. It is critical for development and...
Nakayama, Takahiro, Nishioka, Kenichi, Dong, Yi-Xin, Shimojima, Tsukasa, Hirose, Susumu
Epigenetic maintenance of the expression state of the genome is critical for development. Drosophila GAGA factor interacts with FACT and modulates chromatin structure for the maintenance of gene...
Surfaces in the complex projective plane and their mapping class groups (2005)
An orientation preserving diffeomorphism over a surface embedded in a 4-manifold is called extendable, if this diffeomorphism is a restriction of an orientation preserving diffeomorphism on this...
Tsuda, Kenichi, Tsuji, Toshihiro, Hirose, Susumu, Yamazaki, Ken-ichi
Multiprotein bridging factor 1 (MBF1) is known to be a transcriptional co-activator that mediates transcriptional activation by bridging between an activator and a TATA-box binding protein (TBP). We...
Aihara, Hitoshi, Nakagawa, Takeya, Yasui, Kiyoshi, Ohta, Tsutomu, Hirose, Susumu, Dhomae, Naoshi, ...
Posttranslational histone modifications are important for the regulation of many biological phenomena. Here, we show the purification and characterization of nucleosomal histone kinase-1 (NHK-1)....
Aihara, Hitoshi, Nakagawa, Takeya, Yasui, Kiyoshi, Ohta, Tsutomu, Hirose, Susumu, Dhomae, Naoshi, ...
Posttranslational histone modifications are important for the regulation of many biological phenomena. Here, we show the purification and characterization of nucleosomal histone kinase-1 (NHK-1)....
Aihara, Hitoshi, Nakagawa, Takeya, Yasui, Kiyoshi, Ohta, Tsutomu, Hirose, Susumu, Dhomae, Naoshi, ...
Posttranslational histone modifications are important for the regulation of many biological phenomena. Here, we show the purification and characterization of nucleosomal histone kinase-1 (NHK-1)....
Some homological invariants of the mapping class group of a three-dimensional handlebody (2003)
We show that, if g ≥ 2, the virtual cohomological dimension of the mapping class group of a three-dimensional handlebody of genus $\g$ is equal to $4\g-5$ and its Euler number is equal to 0.
Shimojima, Tsukasa, Okada, Masahiro, Nakayama, Takahiro, Ueda, Hitoshi, Okawa, Katsuya, Iwamatsu, Akihiro, ...
Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates...
On diffeomorphisms over surfaces trivially embedded in the 4-sphere (2002)
A surface in the 4-sphere is trivially embedded, if it bounds a 3-dimensional handle body in the 4-sphere. For a surface trivially embedded in the 4-sphere, a diffeomorphism over this surface is...
Some homological invariants of mapping class group of a 3-dimensional handlebody (2001)
We show that, if g is more than or equal to 2, the virtual cohomological dimension of the mapping class group of a 3-dimensional handlebody of genus g is equal to 4g-5 and the Euler number of it is...
S. Gervais gave a finite presentation for the mapping class group of a surface (math.GT/9811162). We show this presentation without using Wajnryb's simple presentation. We use a complex of curves...
Chromatin Remodeling and Transcription (1998)
The chromatin structure is essential not only for the compact packaging of the eukaryotic genome but also for regulation of transcription. This article provides an overview of chromatin modification...
Wada, Tadashi, Takagi, Toshiyuki, Yamaguchi, Yuki, Ferdous, Anwarul, Imai, Takeshi, Hirose, Susumu, ...
The Hox-2.1 gene is one of homeobox-containing genes located in theHox-2 cluster on mouse chromosome 11. In this study, we have examined transcription of the Hox-2.1 gene during differentiation of F9...
Mizutani, Mitsuko, Ura, Kiyoe, Hirose, Susumu
In vitro transcription was reconstituted with HeLa cell transcription factors and RNA polymerase II, which were essentially free from DNA topoisomerase activities. DNA templates with defined negative...
Novel Plasmid Vectors for Gene Cloning in Pseudomonas (1991)
Itoh, Nobuya, Koide, Yoshinao, Fukuzawa, Haruyo, Hirose, Susumu, Inukai, Tadahiko
Novel host-vector systems have been developed for gene cloning in the metabolically versatile bacterial genus Pseudomonas. We found that a new Pseudomonas strain, Pseudomonas flavida IF-4, isolated...
BmFTZ-F1 is a Bombyx mori homologue of FTZ-F1, a positive regulator of the fushi tarazu gene of Drosophila melanogaster. In order to determine the sequence recognized with this factor, we made three...
Negative Supercoiling of DNA by Eukaryotic DNA Topoisomerase II and Dextran Sulfate (1991)
Okada, Kohichi, Ohta, Tsutomu, Hirose, Susumu
In the presence of a molar excess of eukaryotic DNA topoisomerase II and an appropriate concentration of dextran sulfate, relaxed closed circular DNA is converted to a negatively supercoiled form....
Identification and purification of a Bombyx mori homologue of FTZ-F1 (1990)
Extracts from embryos and from posterior and middle silk glands of the silkworm, Bombyx mori contain a sequence specific DNA binding factor termed BmFTZ-F1. The factor binds to the recognition site...
Transcription of Cloned Actin Genes of Dictyostelium discoideum in the Cell-Free System (1984)
TAKIYA, Shigeharu, TABATA, Tetsuya, IWABUCHI, Masaki, HIROSE, Susumu, SUZUKI, Yoshiaki
Truncated templates of a cloned actin gene (actin 5) of Dictyostelium discoideum were transcribed in a HeLa cell extract from a position indistinguishable from the in vivo initiation site. The...
Takemaru, Ken-ichi, Li, Feng-Qian, Ueda, Hitoshi, Hirose, Susumu
Multiprotein bridging factor 1 (MBF1) is a transcriptional cofactor that bridges between the TATA box-binding protein (TBP) and the Drosophila melanogaster nuclear hormone receptor FTZ-F1 or its...
Yeast Coactivator MBF1 Mediates GCN4-Dependent Transcriptional Activation
Takemaru, Ken-ichi, Harashima, Satoshi, Ueda, Hitoshi, Hirose, Susumu
Transcriptional coactivators play a crucial role in gene expression by communicating between regulatory factors and the basal transcription machinery. The coactivator multiprotein bridging factor 1...
DNA Supercoiling Factor Localizes to Puffs on Polytene Chromosomes in Drosophila melanogaster
Kobayashi, Masatomo, Aita, Noriko, Hayashi, Shigeo, Okada, Kohichi, Ohta, Tsutomu, Hirose, Susumu
DNA supercoiling factor (SCF) was first identified in silkworm as a protein that generates negative supercoils in DNA in conjunction with eukaryotic topoisomerase II. To analyze the in vivo role of...
Okada, Masahiro, Hirose, Susumu
GAGA factor is known to remodel the chromatin structure in concert with nucleosome-remodeling factor NURF in a Drosophila embryonic S150 extract. The promoter region of the Drosophila fushi tarazu...
Shimojima, Tsukasa, Okada, Masahiro, Nakayama, Takahiro, Ueda, Hitoshi, Okawa, Katsuya, Iwamatsu, Akihiro, ...
Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates...
Wada, Tadashi, Takagi, Toshiyuki, Yamaguchi, Yuki, Ferdous, Anwarul, Imai, Takeshi, Hirose, Susumu, ...
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA polymerase II (Pol II) in conjunction with the transcription inhibitor...
Phage Particle-Mediated Gene Transfer to Cultured Mammalian Cells
Ishiura, Masahiro, Hirose, Susumu, Uchida, Tsuyoshi, Hamada, Yoshio, Suzuki, Yoshiaki, Okada, Yoshio
Recombinant phage particles carrying the thymidine kinase (TK) gene of herpes simplex virus type 1, coprecipitated with calcium phosphate, efficiently transformed mouse Ltk− cells to the TK+...
Aihara, Hitoshi, Nakagawa, Takeya, Yasui, Kiyoshi, Ohta, Tsutomu, Hirose, Susumu, Dhomae, Naoshi, ...
Posttranslational histone modifications are important for the regulation of many biological phenomena. Here, we show the purification and characterization of nucleosomal histone kinase-1 (NHK-1)....
RNA-Linked Nascent DNA Fragments in Escherichia coli*
Sugino, Akio, Hirose, Susumu, Okazaki, Reiji
Nucleic acid that is extracted from E. coli labeled by a brief pulse of [3H]dT and depatured by treatment with heat, formamide, or formaldehyde bands in a region with a density higher than that of...
Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila
Jindra, Marek, Gaziova, Ivana, Uhlirova, Mirka, Okabe, Masataka, Hiromi, Yasushi, Hirose, Susumu
Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses. AP-1 activity is controlled, in part, by...
Takemaru, Ken-ichi, Li, Feng-Qian, Ueda, Hitoshi, Hirose, Susumu
Multiprotein bridging factor 1 (MBF1) is a transcriptional cofactor that bridges between the TATA box-binding protein (TBP) and the Drosophila melanogaster nuclear hormone receptor FTZ-F1 or its...
Yeast Coactivator MBF1 Mediates GCN4-Dependent Transcriptional Activation
Takemaru, Ken-ichi, Harashima, Satoshi, Ueda, Hitoshi, Hirose, Susumu
Transcriptional coactivators play a crucial role in gene expression by communicating between regulatory factors and the basal transcription machinery. The coactivator multiprotein bridging factor 1...
DNA Supercoiling Factor Localizes to Puffs on Polytene Chromosomes in Drosophila melanogaster
Kobayashi, Masatomo, Aita, Noriko, Hayashi, Shigeo, Okada, Kohichi, Ohta, Tsutomu, Hirose, Susumu
DNA supercoiling factor (SCF) was first identified in silkworm as a protein that generates negative supercoils in DNA in conjunction with eukaryotic topoisomerase II. To analyze the in vivo role of...
Okada, Masahiro, Hirose, Susumu
GAGA factor is known to remodel the chromatin structure in concert with nucleosome-remodeling factor NURF in a Drosophila embryonic S150 extract. The promoter region of the Drosophila fushi tarazu...
Shimojima, Tsukasa, Okada, Masahiro, Nakayama, Takahiro, Ueda, Hitoshi, Okawa, Katsuya, Iwamatsu, Akihiro, ...
Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We show here that Drosophila FACT (facilitates...
Wada, Tadashi, Takagi, Toshiyuki, Yamaguchi, Yuki, Ferdous, Anwarul, Imai, Takeshi, Hirose, Susumu, ...
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA polymerase II (Pol II) in conjunction with the transcription inhibitor...
Phage Particle-Mediated Gene Transfer to Cultured Mammalian Cells
Ishiura, Masahiro, Hirose, Susumu, Uchida, Tsuyoshi, Hamada, Yoshio, Suzuki, Yoshiaki, Okada, Yoshio
Recombinant phage particles carrying the thymidine kinase (TK) gene of herpes simplex virus type 1, coprecipitated with calcium phosphate, efficiently transformed mouse Ltk− cells to the TK+...
Aihara, Hitoshi, Nakagawa, Takeya, Yasui, Kiyoshi, Ohta, Tsutomu, Hirose, Susumu, Dhomae, Naoshi, ...
Posttranslational histone modifications are important for the regulation of many biological phenomena. Here, we show the purification and characterization of nucleosomal histone kinase-1 (NHK-1)....
RNA-Linked Nascent DNA Fragments in Escherichia coli*
Sugino, Akio, Hirose, Susumu, Okazaki, Reiji
Nucleic acid that is extracted from E. coli labeled by a brief pulse of [3H]dT and depatured by treatment with heat, formamide, or formaldehyde bands in a region with a density higher than that of...
Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila
Jindra, Marek, Gaziova, Ivana, Uhlirova, Mirka, Okabe, Masataka, Hiromi, Yasushi, Hirose, Susumu
Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses. AP-1 activity is controlled, in part, by...
Linker histone variants control chromatin dynamics during early embryogenesis
Saeki, Hideaki, Ohsumi, Keita, Aihara, Hitoshi, Ito, Takashi, Hirose, Susumu, Ura, Kiyoe, ...
Complex transitions in chromatin structure produce changes in genome function during development in metazoa. Linker histones, the last component of nucleosomes to be assembled into chromatin,...
Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading
Nakayama, Takahiro, Nishioka, Kenichi, Dong, Yi-Xin, Shimojima, Tsukasa, Hirose, Susumu
Epigenetic maintenance of the expression state of the genome is critical for development. Drosophila GAGA factor interacts with FACT and modulates chromatin structure for the maintenance of gene...
Tan, Bertrand Chin-Ming, Chien, Cheng-Ting, Hirose, Susumu, Lee, Sheng-Chung
Chromatin is suppressive in nature to cellular enzymes that metabolize DNA, mainly due to the inherent inaccessibility of the DNA template. Despite extensive understanding of the involvement of...
RSF Governs Silent Chromatin Formation via Histone H2Av Replacement
Hanai, Kazuma, Furuhashi, Hirofumi, Yamamoto, Takashi, Akasaka, Koji, Hirose, Susumu
Human remodeling and spacing factor (RSF) consists of a heterodimer of Rsf-1 and hSNF2H, a counterpart of Drosophila ISWI. RSF possesses not only chromatin remodeling activity but also chromatin...
Agawa, Yasuo, Sarhan, Moustafa, Kageyama, Yuji, Akagi, Kazutaka, Takai, Masayoshi, Hashiyama, Kazuya, ...
Regulatory mechanisms controlling the timing of developmental events are crucial for proper development to occur. ftz-f1 is expressed in a temporally regulated manner following pulses of ecdysteroid...
Midline governs axon pathfinding by coordinating expression of two major guidance systems
Liu, Qing-Xin, Hiramoto, Masaki, Ueda, Hitoshi, Gojobori, Takashi, Hiromi, Yasushi, Hirose, Susumu
Formation of the neural network requires concerted action of multiple axon guidance systems. How neurons orchestrate expression of multiple guidance genes is poorly understood. Here, we show that...